Lifeboat Foundation

Circa 2015 brain immortality through aldehyde stabilized cryopreservation.

We describe here a new cryobiological and neurobiological technique, aldehyde-stabilized cryopreservation (ASC), which demonstrates the relevance and utility of advanced cryopreservation science for the neurobiological research community. ASC is a new brain-banking technique designed to facilitate neuroanatomic research such as connectomics research, and has the unique ability to combine stable long term ice-free sample storage with excellent anatomical resolution. To demonstrate the feasibility of ASC, we perfuse-fixed rabbit and pig brains with a glutaraldehyde-based fixative, then slowly perfused increasing concentrations of ethylene glycol over several hours in a manner similar to techniques used for whole organ cryopreservation. Once 65% w/v ethylene glycol was reached, we vitrified brains at −135 °C for indefinite long-term storage. Vitrified brains were rewarmed and the cryoprotectant removed either by perfusion or gradual diffusion from brain slices. We evaluated ASC-processed brains by electron microscopy of multiple regions across the whole brain and by Focused Ion Beam Milling and Scanning Electron Microscopy (FIB-SEM) imaging of selected brain volumes. Preservation was uniformly excellent: processes were easily traceable and synapses were crisp in both species. Aldehyde-stabilized cryopreservation has many advantages over other brain-banking techniques: chemicals are delivered via perfusion, which enables easy scaling to brains of any size; vitrification ensures that the ultrastructure of the brain will not degrade even over very long storage times; and the cryoprotectant can be removed, yielding a perfusable aldehyde-preserved brain which is suitable for a wide variety of brain assays.

OmniFoods is far from the only player breaking into the space. Last year, Nestlé announced its entrance into the category, rolling out a vegan tuna product in Switzerland. Impossible has also previously announced it was working on an alternative fish product.

OmniFoods, the Hong Kong startup best known for its fake pork product “OmniPork,” is jumping on what it sees as the next phenomenon: plant-based seafood.

In an announcement first shared with CNN Business, the company said Tuesday it is launching a new line of products that include alternatives to fish fillets, fish burgers and cuts of tuna.

Continue reading “First on CNN Business: Asia’s fake pork titan sets its sights on the next ‘big’ thing” »

Electric bicycles in the rugged moped style are all over the place these days, and for good reason. Unlike fitness e-bikes that are often used for a combination of exercise and leisure riding, electric mopeds are built mostly for good old fashioned getting around. And the Addmotor M-66 R7 moped fully embodies that design ethos. It’s a transportation e-bike that will have you zipping around your city faster than a car and cheaper than a public transport season ticket.

Summary: A study in fruit fly models of autism reveals sleep disruption associated with the neurodevelopmental disorder is associated with elevated levels of serotonin. The origin of the higher levels of serotonin was discovered to be in glial cells in the blood-brain barrier.

Source: Radboud University.

Bad sleep causes severe health issues and affects our ability to concentrate, memorize, and cope with challenging situations. Individuals with neurodevelopmental disorders such as autism and intellectual disability, frequently suffer from sleep problems. However, little is known about their underlying mechanisms.

Physicists have proved that a subatomic particle can switch into its antiparticle alter-ego and back again, in a new discovery revealed today.

The extraordinarily precise measurement was made by UK researchers using the Large Hadron Collider beauty (LHCb) experiment at CERN.

It has provided the first evidence that charm mesons can change into their antiparticle and back again.

Early Tuesday morning, large portions of the web sputtered out for about an hour. The downed sites shared no obvious theme or geography; the outages were global, and they hit everything from Reddit to Spotify to The New York Times. (And yes, also WIRED.) In fact, the only thing they have in common is Fastly, a content-delivery network (CDN) provider whose predawn hiccup reverberated across the internet.

You may not have heard of Fastly, but you likely interact with it in some fashion every time you go online. Along with Cloudflare and Akamai, it’s one of the biggest CDN providers in the world. And while Fastly has been vague about what specific glitch caused Tuesday’s worldwide disruptions, the incident offers a stark reminder of how fragile and interconnected internet infrastructure can be, especially when so much of it hinges on a handful of companies that operate largely outside of public awareness.

GPU shipments were way up during Q1 as Nvidia, AMD, and others struggle to meet ongoing pandemic-driven demand.

Echolocation for humans. Original post https://journals.plos.org/plosone/article…

With enough training, most humans can learn how to echolocate, using their tongue to make clicking sounds, and interpreting the sounds of the echoes that come back, reflected from the surrounding environment.

In as few as 10 weeks, researchers were able to teach participants how to navigate obstacles and recognize the size and orientation of objects using the rebounding calls of their clicks. The experiment involved 12 participants who’d been diagnosed as legally blind during their childhood, and 14 sighted people.

Continue reading “Humans Can Learn How to ‘Echolocate’ in Just 10 Weeks, Experiment Shows” »

Relativity Space, a California-based aerospace manufacturer, has revealed a new rocket that is both 3D printed and fully reusable. The Terran R could serve as a competitor to SpaceX’s Falcon 9 and is planned for launch in 2024.