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It is estimated that there would be more than 90 million people dead and injured within the first few hours of the conflict.

For more, see https://sgs.princeton.edu/the-lab/plan-a.

A collaboration with Alex Wellerstein (http://blog.nuclearsecrecy.com) and Jeff Snyder (https://music.princeton.edu/people/jeff-snyder).

Visit https://brilliant.org/Veritasium/ to get started learning STEM for free, and the first 200 people will get 20% off their annual premium subscription. Digital computers have served us well for decades, but the rise of artificial intelligence demands a totally new kind of computer: analog.

Thanks to Mike Henry and everyone at Mythic for the analog computing tour! https://www.mythic-ai.com/
Thanks to Dr. Bernd Ulmann, who created The Analog Thing and taught us how to use it. https://the-analog-thing.org.
Moore’s Law was filmed at the Computer History Museum in Mountain View, CA.
Welch Labs’ ALVINN video: https://www.youtube.com/watch?v=H0igiP6Hg1k.

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References:
Crevier, D. (1993). AI: The Tumultuous History Of The Search For Artificial Intelligence. Basic Books. – https://ve42.co/Crevier1993
Valiant, L. (2013). Probably Approximately Correct. HarperCollins. – https://ve42.co/Valiant2013
Rosenblatt, F. (1958). The Perceptron: A Probabilistic Model for Information Storage and Organization in the Brain. Psychological Review, 65, 386–408. – https://ve42.co/Rosenblatt1958
NEW NAVY DEVICE LEARNS BY DOING; Psychologist Shows Embryo of Computer Designed to Read and Grow Wiser (1958). The New York Times, p. 25. – https://ve42.co/NYT1958
Mason, H., Stewart, D., and Gill, B. (1958). Rival. The New Yorker, p. 45. – https://ve42.co/Mason1958
Alvinn driving NavLab footage – https://ve42.co/NavLab.
Pomerleau, D. (1989). ALVINN: An Autonomous Land Vehicle In a Neural Network. NeurIPS, 1305-313. – https://ve42.co/Pomerleau1989
ImageNet website – https://ve42.co/ImageNet.
Russakovsky, O., Deng, J. et al. (2015). ImageNet Large Scale Visual Recognition Challenge. – https://ve42.co/ImageNetChallenge.
AlexNet Paper: Krizhevsky, A., Sutskever, I., Hinton, G. (2012). ImageNet Classification with Deep Convolutional Neural Networks. NeurIPS, (25)1, 1097–1105. – https://ve42.co/AlexNet.
Karpathy, A. (2014). Blog post: What I learned from competing against a ConvNet on ImageNet. – https://ve42.co/Karpathy2014
Fick, D. (2018). Blog post: Mythic @ Hot Chips 2018. – https://ve42.co/MythicBlog.
Jin, Y. & Lee, B. (2019). 2.2 Basic operations of flash memory. Advances in Computers, 114, 1–69. – https://ve42.co/Jin2019
Demler, M. (2018). Mythic Multiplies in a Flash. The Microprocessor Report. – https://ve42.co/Demler2018
Aspinity (2021). Blog post: 5 Myths About AnalogML. – https://ve42.co/Aspinity.
Wright, L. et al. (2022). Deep physical neural networks trained with backpropagation. Nature, 601, 49–555. – https://ve42.co/Wright2022
Waldrop, M. M. (2016). The chips are down for Moore’s law. Nature, 530144–147. – https://ve42.co/Waldrop2016

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The CRISPR gene-editing system is a powerful tool that could revolutionize medicine and other sciences, but unfortunately it has a tendency to make edits to the wrong sections of DNA. Now, researchers at the University of Texas at Austin have identified a previously unknown structure of the protein that drives these mistakes, and tweaked it to reduce the likelihood of off-target mutations by 4,000 times.

CRISPR tools use certain proteins, most often Cas9, to make precise edits to specific DNA sequences in living cells. This can involve cutting out problematic genes, such as those that cause disease, and/or slotting in beneficial ones. The problem is that sometimes the tool can make changes to the wrong parts, potentially triggering a range of other health issues.

And in the new study, the UT researchers discovered how some of these errors can happen. Usually, the Cas9 protein is hunting for a specific sequence of 20 letters in the DNA code, but if it finds one where 18 out of 20 match its target, it might make its edit anyway. To find out why this occurs, the team used cryo-electron microscopy to observe what Cas9 is doing when it interacts with a mismatched sequence.