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Sep 27, 2022

Spatiotemporal control of ERK pulse frequency coordinates fate decisions during mammary acinar morphogenesis

Posted by in category: biotech/medical

How do single cells know when and where to proliferate, survive, and die during organ morphogenesis? Ender et al. show how self-organized ERK activity pulses and waves spatiotemporally regulate these fate decisions in a prototype 3D mammary epithelial model.

Sep 27, 2022

Will Ray Kurzweil live forever? | Lex Fridman Podcast Clips

Posted by in categories: life extension, Ray Kurzweil

Lex Fridman Podcast full episode:
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Ray Kurzweil is an author, inventor, and futurist.

Continue reading “Will Ray Kurzweil live forever? | Lex Fridman Podcast Clips” »

Sep 27, 2022

DART asteroid impact impresses in ESA’s view from the ground

Posted by in categories: asteroid/comet impacts, existential risks

Last night at 23:14 UTC, NASA’s DART spacecraft successfully struck asteroid Dimorphos, the 160-metre moonlet orbiting around the larger Didymos asteroid. About 38 seconds later, the time it took for the light to arrive at Earth, people all over the world saw the abrupt end of the live stream from the spacecraft, signalling that the impact had happened successfully – DART was no more.

Astronomers on a small slice of our planet’s surface, extending from southern and eastern Africa to the Indian Ocean and the Arabian Peninsula, could actually watch it live with their telescopes. Among those were a half dozen stations joined together for a dedicated observing campaign organised by ESA’s Planetary Defence Office and coordinated by the team of observers of the Agency’s Near-Earth Object Coordination Centre (NEOCC). As usual, when such a timely astronomical event happens, not all stations were successful in their observations: clouds, technical problems and other issues always affect real-life observations.

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Sep 27, 2022

‘Iconic’ plant family at risk: Scientists estimate more than half of palm species may be threatened with extinction

Posted by in categories: existential risks, robotics/AI

In a new paper published today in the journal Nature Ecology and Evolution, scientists have estimated the conservation status of nearly 1,900 palm species using artificial intelligence, and found more than 1,000 may be at risk of extinction.

The international team of researchers from the Royal Botanic Gardens, Kew, the University of Zurich, and the University of Amsterdam, combined existing data from the International Union for Conservation of Nature (IUCN) Red List with novel machine learning techniques to paint a clearer picture of how palms may be threatened. Although popular and well represented on the Red List, the threat to some 70% of these plants has remained unclear until now.

The IUCN Red List of Threatened Species is widely considered to be a gold standard for evaluating the conservation status of animal, plant, and . But there are gaps in the Red List that need to be addressed, as not all species have been listed and many of the assessments are in need of an update. Conservation efforts are further complicated by inadequate funding, the sheer amount of time needed to manually assess a species, and public perception favoring certain over plants and fungi.

Sep 27, 2022

Texas population growth expected to put strain on water supply

Posted by in category: futurism

A Texas Water Development Board plan shows the state population is supposed to increase more than 70% by 2070, which is expected to strain our water supply.

Sep 27, 2022

Technology produces more than 100 medical microrobots per minute that can be disintegrated in the body

Posted by in categories: 3D printing, biotech/medical, nanotechnology, robotics/AI

Daegu Gyeongbuk Institute of Science & Technology (DGIST, President Yang Kook) Professor Hongsoo Choi’s team of the Department of Robotics and Mechatronics Engineering collaborated with Professor Sung-Won Kim’s team at Seoul St. Mary’s Hospital, Catholic University of Korea, and Professor Bradley J. Nelson’s team at ETH Zurich to develop a technology that produces more than 100 microrobots per minute that can be disintegrated in the body.

Microrobots aiming at minimal invasive targeted precision therapy can be manufactured in various ways. Among them, ultra-fine 3D called two-photon polymerization method, a method that triggers polymerization by intersecting two lasers in synthetic resin, is the most used. This technology can produce a structure with nanometer-level precision. However, a disadvantage exists in that producing one microrobot is time consuming because voxels, the pixels realized by 3D printing, must be cured successively. In addition, the magnetic nanoparticles contained in the robot can block the light path during the two-photon polymerization process. This process result may not be uniform when using magnetic nanoparticles with high concentration.

To overcome the limitations of the existing microrobot manufacturing method, DGIST Professor Hongsoo Choi’s research team developed a method to create microrobots at a high speed of 100 per minute by flowing a mixture of magnetic nanoparticles and gelatin methacrylate, which is biodegradable and can be cured by light, into the microfluidic chip. This is more than 10,000 times faster than using the existing two-photon polymerization method to manufacture microrobots.

Sep 27, 2022

Microrobots for treating neurological diseases through intra-nasal administration

Posted by in categories: biotech/medical, nuclear energy, robotics/AI

The joint research team of Professor Choi Hongsoo at Robotics Engineering, DGIST, a senior researcher Jinyoung Kim from DGIST-ETH Microrobotics Research Center, and the research team of Professor Sung Won Kim at Seoul St. Mary’s Hospital of the Catholic University, made a breakthrough for the improvement of the therapeutic efficacy and safety in stem cell-based treatments.

The team developed a magnetically powered human nuclear transfer (hNTSC)-based and a method of minimally invasive of therapeutic agents into the brain via the intranasal pathway. And they also accomplished transplanting the developed stem cell-based microrobot into brain tissue through the intranasal pathway that bypasses the . The proposed method is superior in efficacy and safety compared to the conventional surgical method and is expected to bring new possibilities of treating various intractable neurological diseases such as Alzheimer’s disease, Parkinson’s disease, and brain tumors, in the future.

The limitation of stem cell therapy is the difficulty in delivering an exact amount of stem to an accurate targeted location deep in the body where the treatment is with high risk. Another limitation is that both efficacy and safety of the treatment are low owing to a large amount of the therapeutic agent loss during delivery, while the cost of the treatment is high. In particular, when delivering stem cells into the brain through blood, the efficiency of cell delivery may decrease owing to the “blood-brain barrier,” which is a unique and specific component of the cerebrovascular network.

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Sep 27, 2022

Microrobots used to build bridge between rat nerve cell networks

Posted by in category: robotics/AI

One day they shall make nano bots out of graphine.

A team of researchers affiliated with several institutions in South Korea has created microrobots that are able to serve as bridge builders between rat nerve cell networks. In their paper published in the journal Science Advances, the group describes how their microrobots were constructed and how well they served as a bridge builder between neural networks.

Scientists have taken many approaches to study of the brain. One way is to try to grow a brain from nerve cells. Prior work has shown that it is possible to grow a network of neural cells on a Such a network is, of course, 2-D. In this new effort, the researchers have taken a step toward the creation of a 3D neural network by devising a way to connect 2-D neural networks using microrobots.

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Sep 27, 2022

New longevity centre looks at how to reverse ageing and prolong disease-free years

Posted by in categories: biotech/medical, life extension

The NUHS Centre for Healthy Longevity will look for biomarkers of ageing and test ways to slow ageing.

Sep 27, 2022

George Church: Learn from COVID and fast-track therapies that reverse aging

Posted by in categories: bioengineering, biotech/medical, genetics, life extension

All eyes are on the Emerald Isle this week as the Longevity Summit Dublin brings together a host of speakers covering the spectrum of this booming sector. Delegates have been hearing from some of the leading entrepreneurs, companies, investors, and researchers in the field as they address many of the hot-button topics affecting longevity. One of those speakers is the so-called “father of genomics” – Harvard professor of genetics, George Church – who closes the conference later today with a keynote on Gene, cell and organ therapies for de-aging.

Longevity. Technology: In addition to his Harvard professorship, Church heads up synthetic biology at the Wyss Institute, where he oversees development of new tools with applications in regenerative medicine. Much of his focus more recently has been on the development of gene therapies targeting age-related disease, a passion that led him to co-found Rejuvenate Bio, with the goal of creating “full age reversal gene therapies.” We caught up with Church ahead of his Dublin presentation for a brief conversation on longevity.

Dr Church’s name is synonymous with genomic science, and he was a key contributor to the Human Genome Project and technologies including next-generation fluorescent and nanopore sequencing, aimed at understanding genetic contributions to human disease. However, he doesn’t feel that those initiatives did a huge amount to move the aging field forward.

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