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Open-source FLIM Playground could speed reproducible analysis of complex cell images

Modern fluorescence microscopy can generate images of living cells as stunning to look at as they are informative to study. For techniques like fluorescence lifetime imaging microscopy (FLIM), those images provide a window into cell metabolism, helping scientists study cancer treatment, autoimmune disease and more.

But for these researchers, the image is just the beginning. To draw any biological insights, researchers need to guide massive amounts of data through a maze of software analysis tools and scripts, ensuring careful quality checks throughout the journey.

Morgridge Institute for Research scientists in the Melissa Skala Lab are tackling this challenge head-on. They have developed a new open-source, user-friendly data analysis platform, FLIM Playground, designed to make FLIM analysis easier, faster and more reproducible. Their work appears in Cell Reports Methods.

This Quantum Detector Boosts Terahertz Sensitivity by 20 Times

The researchers believe the technology could eventually operate at temperatures higher than those required by many competing detector designs. Similar PETS devices have already demonstrated performance at temperatures reachable using compact cryocoolers rather than liquid helium.

That capability could help fill the gap between highly sensitive cryogenic detectors and lower-sensitivity room-temperature technologies, potentially expanding the range of real-world applications.

The study marks the first demonstration of a quantum metasurface photodetector based on a two-dimensional electron system. By combining efficient light collection with a highly sensitive quantum detection mechanism, the work represents a significant step toward overcoming long-standing challenges in terahertz technology.

Ivanti, Fortinet, and SAP Release Patches for Multiple Critical Vulnerabilities

Fortinet, Ivanti, and SAP have released security updates to address multiple critical security vulnerabilities that could result in arbitrary code execution and information disclosure.

The security flaw patched by Fortinet relates to a command injection vulnerability in FortiSandbox, FortiSandbox Cloud, and FortiSandbox PaaS WEB UI. It’s tracked as CVE-2026–25089 (CVSS score: 9.1).

“An improper neutralization of special elements used in an OS command vulnerability [CWE-78] in FortiSandbox, FortiSandbox Cloud and FortiSandbox PaaS WEB UI may allow an unauthenticated attacker to execute unauthorized commands via specifically crafted HTTP requests,” Fortinet said.

Oracle PeopleSoft servers hacked in ShinyHunters data theft attacks

Oracle PeopleSoft servers are being targeted in ongoing data theft attacks by the ShinyHunters extortion gang, which claims to have stolen data from over 100 organizations.

PeopleSoft is an enterprise business software suite used by large organizations to manage business operations such as human resources, payroll, finance, supply chain management, procurement, and student administration.

Yesterday, BleepingComputer learned of widespread data theft attacks targeting both cloud and on-premises Oracle PeopleSoft customer instances. These customers were receiving extortion demands that were signed by the ShinyHunters extortion gang.

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Diet remodels chromatin structure and extends survival in models of glioma

An unexpected lab observation has led a team of scientists to discover how diet can influence survival in animal models of glioma, one of the most aggressive and deadly forms of brain cancer. Researchers at Baylor College of Medicine, the Duncan Neurological Research Institute (Duncan NRI) at Texas Children’s Hospital and collaborating institutions report in the Proceedings of the National Academy of Sciences how limiting a single nutrient, the amino acid methionine, in the diet destabilized DNA organization and led to cancer cell death and increased animal survival. These findings open new possibilities for treating one of the most challenging forms of brain cancer.

“Cancer cells, including gliomas, often depend on methionine. Methionine is an essential amino acid, meaning that the body does not produce it on its own; it must be consumed in the diet. Glioma cells are unusually dependent on methionine to fuel rapid growth and control gene activity,” said corresponding author Dr. Benjamin Deneen, professor and Dr. Russell J. and Marian K. Blattner Chair in the Department of Neurosurgery and director of the Center for Cancer Neuroscience, all at Baylor.

“In the current study, we wanted to know, if tumors depend so much on methionine, what happens if we reduce the supply?” said first author Brittney Lozzi, a graduate student in the Deneen lab.

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