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Plant virus triggers immune response that targets and destroys cancer cells

A virus that typically infects black-eyed peas is showing great promise as a low-cost, potent cancer immunotherapy—and researchers are uncovering why.

In a study published in Cell Biomaterials, a team led by chemical and nano engineers at the University of California San Diego took a closer look at how the (CPMV), unlike other plant viruses, is uniquely effective at activating the body’s immune system to recognize and attack cancer cells.

The study is titled “Comparative analyses for plant virus-based cancer immunotherapy drug development.”

Injured once, triggered forever? How the brain rewrites stress responses

A wound can leave a lasting imprint—even after it has healed. A new study in Current Biology finds that past injuries can quietly prime the body to overreact and be more sensitive to stress, pain and fear long after the damage is gone.

These findings may help explain how early injuries or trauma can set the stage for , where the remains hypersensitive long after the initial damage has healed. can set the stage for conditions, where the nervous system remains hypersensitive long after the initial damage has healed.

Researchers at the University of Toronto Mississauga discovered that mice with a history of responded more intensely to the scent of a predator, an extremely stressful event for mice. These mice showed exaggerated and developed long-lasting pain in both hind paws, including the uninjured side. Strikingly, the symptoms lasted more than six months, long after the original injury had physically healed.

Early developmental origins of cortical disorders modeled in human neural stem cells

The implications of early telencephalic development in cortical disorders remain elusive. Here, the authors define risk gene dynamics and perturbation effects in neural stem cells, revealing vulnerability phases during early human corticogenesis.

Researchers create safer nonstick surface, cutting use of ‘forever chemicals’

A new material developed by researchers from University of Toronto Engineering could offer a safer alternative to the nonstick chemicals commonly used in cookware and other applications.

The new substance repels both water and grease about as well as standard nonstick coatings—but it contains much lower amounts of per-and polyfluoroalkyl substances (PFAS), a family of chemicals that have raised environmental and health concerns.

“The research community has been trying to develop safer alternatives to PFAS for a long time,” says Professor Kevin Golovin, who heads the Durable Repellent Engineered Advanced Materials (DREAM) Laboratory at U of T Engineering.