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Part II of a collaboration with Isaac Arthur on the subject of uplifting, the concept of increasing an animal or alien species’ intelligence. Further, we explore the concept of Downshifting, the idea of making deliberately making something less intelligent.

Watch Part 1: • Uplifting Animal & Aliens, Part 1 of 2

Isaac’s video on rare intelligence:

• fermi paradox great filters: rare int…

The Anthropic Principle and Super-Intelligence, or SI, are vital concepts to understanding the Universe and our future place in it.

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A new interview with Dr. Abraham “Avi” Loeb from Harvard and update on the subject of Oumuamua, the Fermi Paradox, interstellar objects. Life around red dwarf stars, solar flares, and the search for intelligent alien civilizations. This is part two of a two part interview with Dr. Loeb. Have Aliens Found Us? A Harvard Astronomer on the Mysterious Interstellar Object ‘Oumuamua : https://www.newyorker.com/news/the-ne… Strange Facts about the Interstellar Visitor Oumuamua: https://www.cfa.harvard.edu/~loeb/SL.pdf “COULD SOLAR RADIATION PRESSURE EXPLAIN ‘OUMUAMUA’S PECULIAR ACCELERATION?”, Bialy and Loeb, 2018 https://arxiv.org/pdf/1810.11490.pdf Is Oumuamua A Light Saul? Featuring Dr. Avi Loeb: • Is ‘Oumuamua a Light Sail? Featuring… Why The Universe May Be Full Of Alien Civilizations Featuring Dr. Avi Loeb: • Why The Universe May Be Full Of Alien… Website: https://www.eventhorizonshow.com/ You can now support us on Patreon! / eventhorizonshow Follow us on Twitter! / jmgeventhorizon Follow us on Instagram! / jmgeventhorizon.

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Terraforming an entire planet is a colossal undertaking that will take lifetimes to complete. So assuming you’re that committed to seeing it through, how do you even start?

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Visualizing cells after editing specific genes can help scientists learn new details about the function of those genes. But using microscopy to do this at scale can be challenging, particularly when studying thousands of genes at a time.

Now, researchers at the Broad Institute of MIT and Harvard, along with collaborators at Calico Life Sciences, have developed an approach that brings the power of microscopy imaging to genome-scale CRISPR screens in a scalable way.

PERISCOPE—which stands for perturbation effect readout in situ via single-cell optical phenotyping—combines two technologies developed by Broad scientists: Cell Painting, which can capture images and key measures of subcellular compartments at scale, and Optical Pooled Screening, which “barcodes” cells and uses CRISPR to systematically turn off individual genes to study their function in those cells.

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Through his research, the physician believes there are clues hinting at our reality being a simulation, an has even suggested that mutations are not random — which would debunk the theory of evolution.

The abstract of Vopson’s study read: The simulation hypothesis is a philosophical theory, in which the entire universe and our objective reality are just simulated constructs.

Despite the lack of evidence, this idea is gaining traction in scientific circles as well as in the entertainment industry.

📝 — Kim, et al.

The goal of the present study was to identify potential pivotal molecules with implications for novel and efficacious treatment options for pancreatic cancer, a disease with limited treatments available and notorious for its aggressive nature.

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Pancreatic cancer is one of the most aggressive forms of cancer and is the seventh leading cause of cancer deaths worldwide. Pancreatic ductal adenocarcinoma (PDAC) accounts for over 90% of pancreatic cancers. Most pancreatic cancers are recalcitrant to radiation, chemotherapy, and immunotherapy, highlighting the urgent need for novel treatment options for this deadly disease. To this end, we screened a library of kinase inhibitors in the PDAC cell lines PANC-1 and BxPC-3 and identified two highly potent molecules: Aurora kinase inhibitor AT 9,283 (AT) and EGFR kinase inhibitor WZ 3,146 (WZ). Both AT and WZ exhibited a dose-dependent inhibition of viability in both cell lines.