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Brain cells fine-tuned to disappointment may inspire new therapies for depression and addiction

University of Oregon neuroscientists have identified a group of brain cells that essentially act as a “disappointment meter,” announcing when reality is falling short of expectations.

In a study published in Current Biology, the researchers describe a specific group of neurons in the mouse brain that become active when the animal anticipates a reward but earns less than expected, or nothing at all. The findings reveal that feeling let down is something that particular cells in the brain are designed to detect and record.

New RNA sequencing method reveals hidden layer of immune system control

Researchers at University Medical Center Utrecht have uncovered a previously underappreciated mechanism that helps immune cells to respond rapidly to infections. Using advanced long-read RNA sequencing, the team shows that alternative RNA splicing, which means how genes are edited into different messenger RNA variants, plays a central role in shaping immune responses. The findings provide new insights into immune-mediated diseases (such as infections, rheumatoid arthritis and lupus) and may open the door to more targeted therapies.

The study, published in Nature Communications, focused on monocytes, a type of innate immune cell that acts as a first responder to pathogens. When these cells encounter bacterial components such as cell wall components, they must quickly adapt to mount an effective defense. While earlier research has largely examined changes in overall gene expression, this study zoomed in on RNA isoforms, the different transcript variants that a single gene can produce.

Using long-read RNA sequencing, researchers at the Center for Translational Immunology (University Medical Center Utrecht, the Netherlands) generated a comprehensive map of full-length RNA transcripts in human monocytes before and after activation. They identified more than 24,000 isoforms, of which the majority have never been described, revealing a previously hidden layer of molecular complexity.

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Tech Whistleblower: You Only Have 3 Years Left Before It Hits! — Mo Gawdat

AI Expert Mo Gawdat returns to The Diary Of A CEO to reveal why AGI has already arrived, why 30% of jobs will disappear by 2027, and why the most dangerous thing about AI isn’t the technology — it’s the people in charge of it.

Mo Gawdat is the former Chief Business Officer at Google X, founder of One Billion Happy, and co-founder of Emma. Love. He is a 4x international bestselling author, and his upcoming book ‘Alive: A Human’s Guide to Living in the World of AI’, will be released in October 2026.

He explains:
◾How AI can give you a 400-point IQ boost, and why most people are wasting it.
◾ Why Mo actually wants a machine smarter than all of humanity to take control.
◾Why Sam Altman said AI will \.

Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks

In a nonhuman primate model, Fujimoto et al. show that deep brain stimulation promotes white matter remodeling and reorganizes brain-wide functional networks, detailing a mechanism through which this neuromodulation therapy may treat depression.

Smaller nanoplastics trigger stronger changes in brain neuron activity

Smaller plastic particles have more effects on neurons, the key information processing cells of the brain, new research from the University of Eastern Finland shows. In the study, neuronal cells were exposed to polystyrene nanoplastics at low doses to study subtle changes.

Plastic production continues to rise, despite worldwide concerns. In addition to environmental implications, there is an increasing interest in how exposure to plastics may impact human health, but our understanding is still limited. Only recently it was shown that plastics can accumulate also in the human brain.

Plastic particles smaller than 5,000 nm in diameter are called microplastics, and the smallest plastic particles with a diameter of less than 1,000 nm are called nanoplastics. The small size of nanoplastics enables them to interact with various cell types, and other particles or biological mass, such as bacteria. Compared to microplastics, nanoplastics have larger adsorption capacity and penetrate through biological barriers more easily. This makes them potentially more harmful and a compelling target for research in the field of neurobiology.

E.W. Dijkstra Archive: On the cruelty of really teaching computing science (EWD 1036)

For Dijkstra, programming was closer to mathematics than to a craft. The goal wasn’t to “get a feel” for code. The goal was to reason about it rigorously, to understand why it works before discovering whether it works.


The second part of this talk pursues some of the scientific and educational consequences of the assumption that computers represent a radical novelty. In order to give this assumption clear contents, we have to be much more precise as to what we mean in this context by the adjective “radical”. We shall do so in the first part of this talk, in which we shall furthermore supply evidence in support of our assumption.

The usual way in which we plan today for tomorrow is in yesterday’s vocabulary. We do so, because we try to get away with the concepts we are familiar with and that have acquired their meanings in our past experience. Of course, the words and the concepts don’t quite fit because our future differs from our past, but then we stretch them a little bit. Linguists are quite familiar with the phenomenon that the meanings of words evolve over time, but also know that this is a slow and gradual process.

It is the most common way of trying to cope with novelty: by means of metaphors and analogies we try to link the new to the old, the novel to the familiar. Under sufficiently slow and gradual change, it works reasonably well; in the case of a sharp discontinuity, however, the method breaks down: though we may glorify it with the name “common sense”, our past experience is no longer relevant, the analogies become too shallow, and the metaphors become more misleading than illuminating. This is the situation that is characteristic for the “radical” novelty.

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