Aug 5, 2021
Marijuana-Like Brain Substance Calms Seizures but Increases After-Effects
Posted by Jason Blain in categories: biotech/medical, chemistry, neuroscience
But 2-AG is almost immediately converted to arachidonic acid, a building block for inflammatory compounds called prostaglandins. The researchers showed that the ensuing increase in arachidonic acid levels resulted in the buildup of a particular variety of prostaglandin that causes constriction of tiny blood vessels in the brain where the seizure has induced thatprostaglandin’s production, cutting off oxygen supply to those brain areas.
Summary: The release of 2-AG, a natural endocannabinoid that is suggested to be the brain’s equivalent to THC, dampens down seizure activity but increases post-seizure oxygen deprivation in the brain.
Source: Stanford
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