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Johns Hopkins Unlocks New Chemistry for Faster, Smaller Microchips

“By playing with the two components (metal and imidazole), you can change the efficiency of absorbing the light and the chemistry of the following reactions. And that opens us up to creating new metal-organic pairings,” Tsapatsis said. “The exciting thing is there are at least 10 different metals that can be used for this chemistry, and hundreds of organics.”

Looking Ahead to Next-Gen Manufacturing

The researchers have started experimenting with different combinations to create pairings specifically for B-EUV radiation, which they say will likely be used in manufacturing in the next 10 years.

Rising Cognitive Disability as a Public Health Concern Among US Adults

From 2013 to 2023, rates of cognitive disability nearly doubled among U.S. adults under 40.

Cognitive disability includes self-reported serious difficulty concentrating, remembering, or making decisions.

Rates are highest among people with chronic diseases or lower household incomes.

Background and Objectives.

Key driver of pancreatic cancer spread identified

A Cornell-led study has revealed how a deadly form of pancreatic cancer enters the bloodstream, solving a long-standing mystery of how the disease spreads and identifying a promising target for therapy.

Pancreatic ductal adenocarcinoma is among the most lethal cancers, with fewer than 10% of patients surviving five years after diagnosis. Its microenvironment is a dense, fibrotic tissue that acts like armor around the tumor. This barrier makes difficult and should, in theory, prevent the tumor from spreading. Yet the cancer metastasizes with striking efficiency—a paradox that has puzzled scientists.

New research published in the journal Molecular Cancer reveals that a biological receptor called ALK7 is responsible, by activating two interconnected pathways that work in tandem. One makes cancer cells more mobile through a process called , and the other produces enzymes that physically break down the .

Enhanced CAR T cells emerge from genetic screening

CAR T cells are patient-derived, genetically engineered immune cells. They are “living drugs” and constitute a milestone in modern medicine. Equipping T cells, a key cell type of the immune system, with a “chimeric antigen receptor” (CAR) enables them to specifically recognize and attack cancer cells.

CAR T cell therapy has demonstrated its potential by curing patients with otherwise untreatable blood cancers. But it still fails for most patients, often due to T cell intrinsic dysfunction. To address their current limitations and to make CAR T cells intrinsically stronger, scientists at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences and the Medical University of Vienna have developed a new method for systematic discovery of genetic boosters of CAR T cell function.

The new study, published in Nature, introduces CELLFIE, a CAR T cell engineering and high-content CRISPR screening platform, enabling researchers to systematically modify CAR T cells and evaluate their therapeutic potential.

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