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Older Apple computers can often be something of a collector’s item, with the oldest fetching an enormously high price in auctions. The ones from the late ’80s and early ’90s don’t sell for quite as much yet, but it’s possible that museums and collectors of the future will one day be clamoring for those as well. For that reason, it’s generally frowned upon to hack or modify original hardware. Luckily, this replica of an Apple Macintosh didn’t harm any original hardware yet still manages to run software on bare metal.

The computer is built around a single-board computer, but this SBC isn’t like the modern ARM machines that have become so ubiquitous. It’s a 133MHz AMD 486 which means that it can run FreeDOS and all of the classic DOS PC games of that era without emulation. In order to run Apple’s legacy operating system, however, it does require the use of the vMac emulator, but the 486 is quite capable of handling the extra layer of abstraction. The computer also sports a real SoundBlaster ISA sound card, uses a microSD card for its hard drive, and uses an 800×600 LCD screen.

As a replica, this computer is remarkably faithful to the original and even though it doesn’t ship with a Motorola 68,000 it’s still fun to find retro PC gamers that are able to run their games on original hardware rather than emulation. It reminds us of another retro 486 that is capable of running old games on new hardware without an emulator as well.

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Info from Japan.

TOKYO, Jan 31 (Reuters) — Japanese trading and pharmaceuticals company Kowa Co Ltd (7807.T) on Monday said that anti-parasite drug ivermectin showed an “antiviral effect” against Omicron and other coronavirus variants in joint non-clinical research.

The company, which has been working with Tokyo’s Kitasato University on testing the drug as a potential treatment for COVID-19, did not provide further details. The original Reuters story misstated that ivermectin was “effective” against Omicron in Phase III clinical trials, which are conducted in humans.

Clinical trials are ongoing, but promotion of ivermectin as a COVID-19 treatment has generated controversy.

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For the first time, SpaceX has converted a flight-proven Falcon Heavy side core into a Falcon 9 booster and successfully launched the reborn rocket, carrying an Italian Earth observation satellite to orbit with one of the most visually spectacular Falcon launches in recent memory.

After a tortured campaign of four scrubbed or aborted launch attempts between January 27th and 30th, Falcon 9 finally lifted off from SpaceX’s Cape Canaveral Space Force Station (CCSFS) LC-40 pad at 6:11 pm EST (23:11 UTC) on Monday, January 31st. The converted Falcon Heavy booster performed perfectly on its first solo mission, successfully carrying a Falcon upper stage and Italy’s CSG-2 synthetic aperture radar (SAR) Earth observation satellite to an altitude of 70 km (~45 mi) and a velocity of ~1.7 km/s (Mach 5) – effectively the edge of space.

Thanks to near-perfect weather and the timing of the launch about 15 minutes after sunset, Falcon Heavy side core B1052’s first mission as a Falcon 9 booster wound up producing some of the best views of a SpaceX launch in the company’s history. As the rocket ascended, the sky continued to darken for local ground observers. It wasn’t long before Falcon 9’s shiny, white airframe ascended into direct sunlight, which created some extraordinary contrast against the darkening sky for tracking cameras near the launch site.

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Summary: Participating in high levels of physical activities, such as swimming or a game of tennis, once a week helps stave off chronic musculoskeletal pain.

Source: University of Portsmouth.

Those hoping to avoid one of the worst side effects of aging—bone, joint and muscle pain that doesn’t go away—might need to exercise a lot harder and more often than previously believed.

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Hibernating astronauts could be the best way to save mission costs, reduce the size of spacecraft by a third and keep crew healthy on their way to Mars. An ESA-led investigation suggests that human hibernation goes beyond the realm of science-fiction and may become a game-changing technique for space travel.

When packing for a return flight to the Red Planet, space engineers account for around two years’ worth of food and water for the crew.

“We are talking about 30 kg per astronaut per day, and on top of that we need to consider radiation as well as mental and physiological challenges,” explains Jennifer Ngo-Anh, ESA research and payload coordinator of Human and Robotic Exploration and one of the authors of the paper that links biology to engineering.

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Bear-like human hibernation could enable ambitious proposals for Mars.

On Monday, the European Space Agency published a report explaining how hibernation could help humanity get to Mars. The agency explained that when bears hibernate, they use fewer resources without letting their muscles and bones go to waste.

For a multi-month trip to Mars, it could help a crew complete their trip with reduced stress levels and fewer medical complications. Crew members would enter pods, administer a drug, and let the ship handle operations for most of the flight.

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