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A tiny marine creature with a strange lifestyle may provide valuable insights into human neurodegenerative disorders, such as Alzheimerâs disease, according to scientists at Stanford Medicine.
Botryllus schlosseri, also called a star tunicate, is humansâ closest evolutionary relative among invertebrates in the sea. Attached to rocks along the coast, it appears as a tiny flower-shaped organism. Star tunicates start life as little tadpole-like creatures with two brains, swimming in the ocean. But eventually they drift down from the surface, settling into a stationary life on a rock, joining a colony of other tunicates.
As the tunicate, also known as a sea squirt, adapts to its new couch-potato lifestyle, it loses brain power: One of the two brains, its use for sea navigation now obsolete, begins to dissolve. The way the invertebrateâs brain degenerates and disappears has important parallels to the way the brain degenerates in human neural disorders, said Irving Weissman, MD, director of the Institute for Stem Cell Biology and Regenerative Medicine.