Lifeboat Foundation

Buck Institute researchers have discovered and are developing a novel, non-invasive biomarker test that can be used to measure and track performance of senolytics: a class of drugs that selectively eliminate senescent cells. The discovery is expected to play a major role in efforts to develop treatments that would battle a myriad of chronic age-related conditions that range from arthritis to lung disease to Alzheimer’s disease and glaucoma. This biomarker is a unique signaling lipid metabolite, normally exclusively intracellular, but is released when senescent cells are forced to die. This metabolite is detectible in blood and urine, making non-invasive testing possible. With a growing list of senolytic drugs in development, detecting this metabolite via a companion test could verify performance of senolytic candidates.

“The list of age-related diseases definitively linked to cellular senescence keeps growing, as does the number of biotech companies racing to develop drugs to eliminate senescent cells,” said Buck professor Judith Campisi, Ph.D., senior scientist on the study. “While the field has never been more promising, the lack of a simple biomarker to measure and track efficacy of these treatments has been a hindrance to progress. We are excited to bring this new biomarker to the field and look forward to it being used in the clinic.”

People into aging/longevity research probably know all of what’s here already.

Aubrey de Grey has been the leading voice for antiaging, aging reversal and aging damage repair for over twenty years. He founded the SENS non-profit (Strategies for Engineered Negligible Senescence (SENS). There have been six antiaging companies that have been directly spun out of SENS is researching the hardest problems related to fixing aging damage.

Repairing damage in five of the areas of aging are now highly active areas of biotech research.

Continue reading “How the World Defeats Aging by 2035” »

There’s no doubt that air taxis will be the next mobility solution that mankind is looking to implement. Actually, this process has been underway for a few years now.

Roughly 4 billion years ago, Mars looked a lot different than it does today. For starters, its atmosphere was thicker and warmer, and liquid water flowed across its surface. This included rivers, standing lakes, and even a deep ocean that covered much of the northern hemisphere. Evidence of this warm, watery past has been preserved all over the planet in the form of lakebeds, river valleys, and river deltas.

For some time, scientists have been trying to answer a simple question: where did all that water go? Did it escape into space after Mars lost its atmosphere, or retreat somewhere? According to new research from Caltech and the NASA Jet Propulsion Laboratory (JPL), between 30% and 90% of Mars’ water went underground. These findings contradict the widely-accepted theory that Mars lost its water to space over the course of eons.

The research was led by Eva Scheller, a Ph.D. candidate at the California Institute of Technology (Caltech). She was joined by Caltech Prof. Bethany Ehlmann, who is also the associate director for the Keck Institute for Space Studies; Caltech Prof. Yuk Yung, a senior research scientist with NASA JPL; Caltech graduate student Danica Adams; and JPL research scientist Renyu Hu.

“Last year’s stimulus was about keeping the economy going, but these companies didn’t use these resources to retain their workers. These are companies that are polluting the environment, increasing the deadliness of the pandemic and letting go of their workers.”

Figures show 77 companies received $8.2bn under tax changes related to Covid relief and yet almost every one let workers go.

The results of this study confirm a direct link, on a molecular level, between the gut microbiome and brain function.

Summary: Consuming high levels of sugar-sweetened beverages early in life may lead to memory problems during adulthood. Researchers found, compared to rats who consumed only water, those who drank sugar-sweetened beverages had difficulties in memory recall associated with the hippocampus. The study also found a link between specific changes in gut bacteria in rats who drank sugary drinks and impaired brain function.

Source: USC

Continue reading “Not So Sweet: Sugary Diet Early in Life Could Lead to Cognitive Problems Later” »

In the last decade, researchers have come to realize that tumors harbor bits of extrachromosomal DNA that can drive malignancy.

Today, we chronicle the progress of partial cellular reprogramming and discuss how this powerful treatment may be able to reprogram cells back into a youthful state, at least partially reversing epigenetic alterations, one of the proposed reasons we age.

For those of you new to the subject of epigenetic alterations you can learn more by clicking on the topic box below, for the more seasoned readers, feel free to skip ahead.

# **The SRIC3 Program is now online!**

Space Renaissance just published the Program of the SRIC3 World Congress The Civilian Space Development\.

Continue reading “Schedule Space Renaissance” »