Lifeboat Foundation

Summary: A new study sheds light on how highly sensitive people process information. After experiencing something emotionally evocative, brain activity displayed a depth of processing while at rest. Depth of processing is a key feature of high emotional sensitivity.

Source: UC Santa Barbara.

You know that raw overwhelm people have been reporting after months of a pandemic, compounded by economic issues and social unrest? Does fatigue and compulsive social media scrolling strike a familiar chord?

Aging is the biggest risk factor for perturbation of the nervous system, even in the absence of distinct disease or trauma. For yet unknown reasons, the impulse conducting, myelinated projections and synaptic connections between nerve cells are especially vulnerable to aging-related degeneration. These pathological alterations often manifest as cognitive, sensory, and motor decline in older adults and represent a serious socio-economic challenge.

Malactivation leads to damage

Scientists have long assumed that inflammation plays an important role in this process. Mal-or overactivation of distinct cells belonging to the innate immune system—the microglia—appears to promote damage of nerve fibers and synapses in the aging central nervous system (CNS). In a recent project, scientists of the University Hospital Würzburg have now discovered an important role of the adaptive immune system.

SpaceX is performing a test flight of Starship SN15. The prototype will aim to be the first Starship vehicle to softly land during a high altitude flight test. Like the previous Starship prototypes, SN15 is expected to fly to approximately 10 kilometers.

Updates: https://forum.nasaspaceflight.com/index.php?topic=52398.

Continue reading “LIVE: Starship SN15 Flight Test” »

The new Stan Smith Mylo is made from materials derived from mushroom and aims to add to Adidas’ sustainability efforts.

SpaceX has once again scrubbed the latest major flight test of its Starship rocket. The next-generation spacecraft was set to launch from SpaceX’s Starbase facility in Boca Chica, Texas, on Tuesday, but cancelled it for reasons unknown.

Starship SN15’s high-altitude flight test follows four previous attempts that all ended in massive explosions. SpaceX boss Elon Musk said previous issues with the rocket’s Raptor engines have been fixed “six ways to Sunday”, though if it fails to land cleanly there are more Starship prototypes currently under development.

Airspace clearance had been approved by the Federal Aviation Administration (FAA), road closures were in place with Cameron County, and marine hazard notices had been issued. The test was expected to take place between 12pm and 8pm local time (6pm — 2am BST) on Tuesday, however a backup launch window is also in place for Wednesday.

Genetic treatments are difficult to produce without facilities.

Af­ter Kel­li Lug­in­buhl fin­ished her PhD, her ad­vi­sor, Duke bio­engi­neer and Phase­Bio co-founder Ashutosh Chilkoti, sat her down and asked if she want­ed to launch and then run a com­pa­ny. Chilkoti had a once-ob­scure tech­nol­o­gy he and the ven­ture cap­i­tal­ist Joe McMa­hon thought could form the ba­sis of his sec­ond com­pa­ny and fi­nal­ly pay huge div­i­dends. Lug­in­buhl knew the tech from years in his lab and was al­ready look­ing for biotech jobs. It all added up.

Three years, some strate­giz­ing, and 10 or so pitch meet­ings lat­er, the trio is launch­ing Isol­ere Bio, with $7 mil­lion in seed fund­ing led by North­pond Ven­tures and tech­nol­o­gy they be­lieve can al­low gene ther­a­py com­pa­nies to vast­ly in­crease the num­ber of dos­es they can pro­duce. It’s one po­ten­tial so­lu­tion to a slow-boil­ing cri­sis that has be­come in­creas­ing­ly acute, as new com­pa­nies strug­gle to get the ma­te­ri­als they need for tri­als and some com­mon dis­eases re­main the­o­ret­i­cal­ly un­fix­able by gene ther­a­py, be­cause com­pa­nies would nev­er be able to make enough dos­es for that many patients.

Continue reading “Startup sets out to tackle the gene therapy manufacturing crisis” »

In diabetic nephropathy—a common cause of kidney disease—levels of NEDD4-2 are severely reduced. This is the case even when salt is not a factor.

University of South Australia researchers have identified an enzyme that may help to curb chronic kidney disease, which affects approximately 700 million people worldwide.

Continue reading “The enzyme that could help 700 million people worldwide” »

Astronomers are hoping to use the wake of stars to test the existing theories of dark matter.

Innovation in Uganda.

Access to clean water may be a right, but it’s often hard to come by. Contaminated water kills. Henry Othieno and Saudah Birungi have developed eco-friendly filters for use in schools and homes. They turn dirty lake water into drinking water.

Continue reading “Uganda: Filters turn dirty lake water into drinking water | Global Ideas” »