Lifeboat Foundation

Daily injections of insulin are a hassle for the hundreds of millions of people with diabetes. An oral pill would be much easier to swallow (pun intended), and now researchers from New York University Abu Dhabi have developed a new method for packing insulin into capsules that can survive the trip through the stomach to the bloodstream, and only release their payload when it’s needed.

Diabetes is characterized by inconsistent levels of insulin, a hormone that regulates glucose levels in the blood. Normally the condition is managed with regular subcutaneous injections, but they can be difficult for patients to self-administer, and the unpleasantness may make some people skip doses.

In an ideal world, managing diabetes would be as simple as popping a pill, but unfortunately developing that kind of system has been tricky. Insulin is a fragile molecule that’s quickly broken down in the stomach before it can work its magic. Much of the challenge for scientists then is to find ways to package insulin so it survives long enough to permeate the intestinal wall to get into the bloodstream.

Summary: Researchers link the inflammation associated with chronic sinus infections to alterations in brain activity in networks that govern cognition, external stimuli, and introspection. The findings shed light on why people suffering from sinus infections often report poor concentration and other short-term cognitive problems.

Source: University of Washington.

The millions of people who have chronic sinusitis deal not only with stuffy noses and headaches, they also commonly struggle to focus, and experience depression and other symptoms that implicate the brain’s involvement in their illness.

TAE Technologies, the California, USA-based fusion energy technology company, has announced that its proprietary beam-driven field-reversed configuration (FRC) plasma generator has produced stable plasma at over 50 million degrees Celsius. The milestone has helped the company raise USD280 million in additional funding.

Norman — TAE’s USD150 million National Laboratory-scale device named after company founder, the late Norman Rostoker — was unveiled in May 2017 and reached first plasma in June of that year. The device achieved the latest milestone as part of a “well-choreographed sequence of campaigns” consisting of over 25000 fully-integrated fusion reactor core experiments. These experiments were optimised with the most advanced computing processes available, including machine learning from an ongoing collaboration with Google (which produced the Optometrist Algorithm) and processing power from the US Department of Energy’s INCITE programme that leverages exascale-level computing.

Plasma must be hot enough to enable sufficiently forceful collisions to cause fusion and sustain itself long enough to harness the power at will. These are known as the ‘hot enough’ and ‘long enough’ milestone. TAE said it had proved the ‘long enough’ component in 2015, after more than 100000 experiments. A year later, the company began building Norman, its fifth-generation device, to further test plasma temperature increases in pursuit of ‘hot enough’.

In recent years, Western brands including Nestlé (NSRGY), Impossible and Beyond Meat (BYND) have tapped into a growing appetite for such food and drinks in the West. Now, they’re headed east, raising fresh funding to target growth in the region, rolling out products specifically created for Asian consumers and setting up new factories on the ground.

Milo chocolate milk has been hugely popular in Southeast Asia for decades. Now the breakfast and teatime favorite is about to get shaken up — the cocoa powder will be offered as a dairy-free, ready-made beverage.

The product is one of Nestlé’s newest plant-based inventions, and it will be launched in the region this week, the company told CNN Business. Starting Thursday, the drink will hit supermarkets in Malaysia, and the Swiss multinational plans to sell it in other countries soon. (The company already offers plant-based Milo in Australia and New Zealand, but in the traditional powder form.)

Continue reading “Milk-free Milo and meatless ‘pork’: Nestlé and other brands bet big on plant-based food in Asia” »

The question cryogenics raises is, can we freeze and then recover consciousness itself as opposed to simply saving imprints of a person’s memories as an AI?

The gene editing system CRISPR-Cas9 makes breaks in DNA strands that are repaired by cells—a process that can be hard to control, resulting in unwanted genetic changes. Researchers at the Massachusetts Institute of Technology and the University of California, San Francisco (UCSF) designed an alternative technology that changes gene expression without damaging DNA, and they believe it could be useful for both research and drug development.

The researchers used their system, dubbed CRISPRoff and CRISPRon, to induce pluripotent stem cells to transform into neurons. They also used it to silence the gene that makes the protein Tau, which has been implicated in Alzheimer’s disease. They described their research in the journal Cell.

The MIT and UCSF researchers started by creating a machine made of a protein and small RNAs that guided it to specific spots on strands of DNA. The machine adds “methyl groups” to genes to silence their expression. The technology can also reverse the process, turning the genes back on by removing the methyl groups.

https://youtube.com/watch?v=OTx9M5L4V0Y

On April 9, 2021 NASA demonstrated video footage on Mars Helicopter Ingenuity during rotor blades spinning test and HI-RES first image from Ingenuity. Launch day of Ingenuity Perseverance Mars Rover sent images of Ingenuity Helicopter’s rotor blades spin up within motor test. Ingenuity is going to fly on Mars on April 11–12. Rotor blades spinned up and are unlocked and helicopter is going to make high-rpm test. So next milestone is to spin up rotor blades full-speed for the first time on Mars (to the planned flight speed of ~2400 RPM) while still on the surface. Flight can’t happen too late in the Martian day either. A long flight late in the afternoon could deplete the battery without giving the Sun a chance to recharge it. You don’t want to go into that cold Martian night without a good bit of energy in the battery!

Credit: nasa.gov, NASA/JPL-Caltech, NASA/JPL-Caltech/ASU

Continue reading “Perseverance captured video of Ingenuity Mars Helicopter rotor blades spinning test” »

A team of theoretical physicists working with Microsoft today published an amazing pre-print research paper describing the universe as a self-learning system of evolutionary laws.

In other words: We live inside a computer that learns.

The big idea: Bostrom’s Simulation Argument has been a hot topic in science circles lately. We published “What if you’re living in a simulation, but there’s no computer” recently to posit a different theory, but Microsoft’s pulled a cosmic “hold my beer” with this paper.

MSU’s expertise in fish biology, genetics helping researchers rewrite evolutionary history and shape future health studies.

The network of nerves connecting our eyes to our brains is sophisticated and researchers have now shown that it evolved much earlier than previously thought, thanks to an unexpected source: the gar fish.

Michigan State University’s Ingo Braasch has helped an international research team show that this connection scheme was already present in ancient fish at least 450 million years ago. That makes it about 100 million years older than previously believed.