David Sinclair is a geneticist at Harvard and author of Lifespan.
Nature – Reversal of biological clock restores vision in old mice
Continue reading “Age Resetting Genes Going to Human Studies in Two Years” »
A strategy for the long fight against COVID-19.
Global herd immunity is now unreachable. How should governments’ strategy in the fight against COVID-19 change in response?
Gosiame Thamara Sithole, 37, was astonished by decuplets after scans only showed eight in the womb.
The Yara Birkeland, the world’s first net-zero, battery-powered autonomous container ship, is undergoing further preparations for autonomous operation and a late 2021 launch.
The Norwegian ship Yara Birkeland, the world’s first net-zero, battery-powered autonomous container ship, is looking at a late 2021 launch.
Summary: The resting brain repeatedly and rapidly replays faster memories of what a person has recently learned and practiced. The more a person replays the memory during rest, the better they become during subsequent sessions where they practice their newly learned skill.
Source: NIH
In a study of healthy volunteers, National Institutes of Health researchers have mapped out the brain activity that flows when we learn a new skill, such as playing a new song on the piano, and discovered why taking short breaks from practice is a key to learning.
An international team of scientists says it has sequenced and assembled the entirety of the human genome, including parts that were missed in the sequencing of the first human genome two decades ago.
The claim, if confirmed, surpasses the achievement laid out by leaders from the Human Genome Project and Celera Genomics on the White House lawn in 2000, when they announced the sequencing of the first draft human genome. That historic draft, and subsequent human DNA sequences, have all missed about 8% of the genome.
The sequencing of the new genome fills in these gaps using new technology. It has different limitations, however, including the type of cell line that the researchers used in order to speed up their effort.
Because it was, 62 years ago, the first fully reusable space vehicle, two stages, both reusable. The same concept of Virgin Galactic SpaceShipTwo.
X15 made 200 flights at suborbital altitude, 100 km.
Continue reading “On This Day in Space! June 8, 1959: X-15 makes first glide flight” »
The bike’s powertrain uses a fuel cell to turn gaseous hydrogen into electrical energy.
The engine setup holds its own, too. The Apex H2 will feature a hybrid powertrain that will convert gaseous hydrogen into electrical energy via a special fuel cell, reports New Atlas. Ninebot says the hydrogen-electric setup will be able to generate over 80 horsepower and rocket the bike from zero to 60 mph in less than four seconds. Considering that the original Segway—yes, the infamous two-wheel personal transporter favored by mall cops—topped out at 10 mph, that’s pretty impressive, even if it is slower than the Apex concept’s quoted top speed of 124 mph. Of course, there’s one key difference between the two bikes: The Apex H2 will be one of the rare concept vehicles you’ll be able to buy.
Bdelloid rotifers are multicellular animals so small you need a microscope to see them. Despite their size, they’re known for being tough, capable of surviving through drying, freezing, starvation, and low oxygen. Now, researchers reporting in the journal Current Biology on June 7 have found that not only can they withstand being frozen, but they can also persist for at least 24000 years in the Siberian permafrost and survive.
“Our report is the hardest proof as of today that multicellular animals could withstand tens of thousands of years in cryptobiosis, the state of almost completely arrested metabolism,” says Stas Malavin of the Soil Cryology Laboratory at the Institute of Physicochemical and Biological Problems in Soil Science in Pushchino, Russia.
The Soil Cryology Lab specializes in isolating microscopic organisms from the ancient permafrost in Siberia. To collect samples, they use a drilling rig in some of the most remote Arctic locations.
Circa 2015 brain immortality through aldehyde stabilized cryopreservation.
We describe here a new cryobiological and neurobiological technique, aldehyde-stabilized cryopreservation (ASC), which demonstrates the relevance and utility of advanced cryopreservation science for the neurobiological research community. ASC is a new brain-banking technique designed to facilitate neuroanatomic research such as connectomics research, and has the unique ability to combine stable long term ice-free sample storage with excellent anatomical resolution. To demonstrate the feasibility of ASC, we perfuse-fixed rabbit and pig brains with a glutaraldehyde-based fixative, then slowly perfused increasing concentrations of ethylene glycol over several hours in a manner similar to techniques used for whole organ cryopreservation. Once 65% w/v ethylene glycol was reached, we vitrified brains at −135 °C for indefinite long-term storage. Vitrified brains were rewarmed and the cryoprotectant removed either by perfusion or gradual diffusion from brain slices. We evaluated ASC-processed brains by electron microscopy of multiple regions across the whole brain and by Focused Ion Beam Milling and Scanning Electron Microscopy (FIB-SEM) imaging of selected brain volumes. Preservation was uniformly excellent: processes were easily traceable and synapses were crisp in both species. Aldehyde-stabilized cryopreservation has many advantages over other brain-banking techniques: chemicals are delivered via perfusion, which enables easy scaling to brains of any size; vitrification ensures that the ultrastructure of the brain will not degrade even over very long storage times; and the cryoprotectant can be removed, yielding a perfusable aldehyde-preserved brain which is suitable for a wide variety of brain assays.
