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According to a new meta-analysis, gene variants associated with a person’s blood type may be linked to their risk of early stroke.

“Non-O blood types have previously been linked to a risk of early stroke, but the findings of our meta-analysis showed a stronger link between these blood types with early stroke compared to late stroke, and in linking risk mostly to blood type A,” said study author Braxton D. Mitchell, PhD, MPH, of University of Maryland School of Medicine in Baltimore. “Specifically, our meta-analysis suggests that gene variants tied to blood types A and O represent nearly all of those genetically linked with early stroke. People with these gene variants may be more likely to develop blood clots, which can lead to stroke.”

48 studies on genetics and ischemic stroke from North America, Europe, and Asia were reviewed in the meta-analysis. 16,927 people with stroke and 576,353 people who did not have a stroke were included in the studies. Of those with stroke, 5,825 people had early onset stroke and 9,269 people had late onset stroke. Early onset stroke was defined as an ischemic stroke occurring before age 60 and late-onset stroke was older than 60 years old.

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A team of researchers from Stanford University has constructed the first synthetic microbiome model, built entirely from scratch and encompassing more than 100 different bacterial species. It’s hoped the achievement will revolutionize gut microbiome research by offering scientists a consistent working model for future experiments.

Trillions of microbes live inside our guts. Perhaps one of the most significant discoveries in medical science over recent decades has been how deeply these microbes influence our general health. From affecting how well drugs we consume work, to modulating our immune systems, the gut microbiome plays a powerful role in all aspects of our health.

It’s also mind-bendingly complex. No two people share exactly the same gut microbiome composition. And while researchers frequently home in on ways particular bacteria influence metabolic mechanisms, it has been difficult to translate these findings into actual clinical therapies for humans.

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A treatment developed by a Japanese doctor and his team is helping women with premature menopause to give birth with their own eggs. Premature menopause is triggered by a malfunctioning of the ovaries and affects even those in their teens. The treatment involves activating dormant primordial follicles. We focus on the method, which has been described by TIME Magazine as a global breakthrough. We also introduce herbs that can alleviate symptoms such as those of menopause.

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Astronomers report the detection of a new brown dwarf as part of the Ophiuchus Disk Survey Employing ALMA (ODISEA) program. The newfound object, designated SSTc2d J163134.1–24006, appears to be experiencing a quasi-spherical mass loss. The discovery was detailed in a paper published September 2 on the arXiv pre-print repository.

Brown dwarfs are intermediate objects between planets and stars, occupying the mass range between 13 and 80 Jupiter masses (0.012 and 0.076 ). They can burn deuterium but are unable to burn regular hydrogen, which requires a minimum mass of at least 80 Jupiter masses and a core temperature of about 3 million K.

A team of led by Dary Ruiz-Rodriguez of the National Radio Astronomy Observatory (NRAO) in Charlottesville, Virginia, have investigated SSTc2d J163134.1–24006, initially identified as a faint stellar object, under the ODISEA project, which is dedicated to study the entire population of protoplanetary disks in the Ophiuchus Molecular Cloud. They found that SSTc2d J163134.1–24006 is most likely a brown dwarf with a mass of about 0.05 solar masses, and an elliptical shell of carbon monoxide (CO).

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An alzheimer’s-proof brain: a groundbreaking case.

In a groundbreaking case researchers from the Massachusetts General Hospital have discovered a gene variant that seems to have disrupted the pathology of Tau Protein. The case of Aliria Rosa Piedrahita de Villegas.

Abstract: Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer’s dementia.

https://link.springer.com/article/10.1007/s00401-022-02467-8

Nature’s Lab Teaches Alzheimer’s Prevention:

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Or so goes the theory. Most CIM chips running AI algorithms have solely focused on chip design, showcasing their capabilities using simulations of the chip rather than running tasks on full-fledged hardware. The chips also struggle to adjust to multiple different AI tasks—image recognition, voice perception—limiting their integration into smartphones or other everyday devices.

This month, a study in Nature upgraded CIM from the ground up. Rather than focusing solely on the chip’s design, the international team—led by neuromorphic hardware experts Dr. H.S. Philip Wong at Stanford and Dr. Gert Cauwenberghs at UC San Diego—optimized the entire setup, from technology to architecture to algorithms that calibrate the hardware.

The resulting NeuRRAM chip is a powerful neuromorphic computing behemoth with 48 parallel cores and 3 million memory cells. Extremely versatile, the chip tackled multiple AI standard tasks—such as reading hand-written numbers, identifying cars and other objects in images, and decoding voice recordings—with over 84 percent accuracy.

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Strange diamonds from an ancient dwarf planet in our solar system may have formed shortly after the dwarf planet collided with a large asteroid about 4.5 billion years ago, according to scientists.

The research team says they have confirmed the existence of lonsdaleite, a rare hexagonal form of diamond, in ureilite meteorites from the mantle of the dwarf planet.

Lonsdaleite is named after the famous British pioneering female crystallographer Dame Kathleen Lonsdale, who was the first woman elected as a Fellow to the Royal Society.

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A study co-led by physicists at UC Riverside and UC Irvine has found that dark matter halos of ultra-diffuse galaxies are very odd, raising questions about physicists’ understanding of galaxy formation and the structure of the universe.

Ultra-diffuse galaxies are so called because of their extremely low luminosity. The distribution of baryons—gas and stars—is much more spread out in ultra-diffuse galaxies compared to “normal” galaxies with similar masses.

In the following Q&A, Hai-Bo Yu, an associate professor of physics and astronomy at UCRhis thoughts on the findings he and UCI’s Manoj Kaplinghat, his long-term collaborator, have published in The Astrophysical Journal about newly discovered ultra-diffuse galaxies and their halos.

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Not everything needs to be seen to be believed; certain things are more readily heard, like a train approaching its station. In a recent paper, published in Physical Review Letters, researchers have put their ears to the rail, discovering a new property of scattering amplitudes based on their study of sound waves through solid matter.

Be it light or sound, physicists consider the likelihood of particle interactions (yes, sound can behave like a particle) in terms of probability curves or scattering amplitudes. It is common lore that when the momentum or energy of one of the scattered particles goes to zero, scattering amplitudes should always scale with integer powers of momentum (i.e., p1, p2, p3, etc.). What the research team found however, was that the can be proportional to a fractional power (i.e., p1/2, p1/3, p1/4, etc.).

Why does this matter? While quantum field theories, such as the Standard Model, allow researchers to make predictions about particle interactions with extreme accuracy, it is still possible to improve upon current foundations of fundamental physics. When a new behavior is demonstrated—such as fractional-power scaling—scientists are given an opportunity to revisit or revise existing theories.

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A new device has been fabricated that can demonstrate the quantum anomalous Hall effect, in which tiny, discrete voltage steps are generated by an external magnetic field. This work may enable extremely low-power electronics, as well as future quantum computers.

If you take an ordinary wire with running through it, you can create a new electrical voltage perpendicular to the flow of current by applying an . This so-called Hall effect has been used as part of a simple magnetic sensor, but the sensitivity can be low.

There is a corresponding quantum version, called the quantum anomalous Hall effect that comes in defined increments, or quanta. This has raised the possibility of using the quantum anomalous Hall effect for the purpose of constructing new highly conductive wires or even quantum computers. However, the physics that leads to this phenomenon is still not completely understood.

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