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Molecular jackhammers eradicate cancer cells by vibronic-driven action

Through the actuation of vibronic modes in cell-membrane-associated aminocyanines, using near-infrared light, a distinct type of molecular mechanical action can be exploited to rapidly kill cells by necrosis. Vibronic-driven action (VDA) is distinct from both photodynamic therapy and photothermal therapy as its mechanical effect on the cell membrane is not abrogated by inhibitors of reactive oxygen species and it does not induce thermal killing. Subpicosecond concerted whole-molecule vibrations of VDA-induced mechanical disruption can be achieved using very low concentrations (500 nM) of aminocyanines or low doses of light (12 J cm-2, 80 mW cm-2 for 2.5 min), resulting in complete eradication of human melanoma cells in vitro. Also, 50% tumour-free efficacy in mouse models for melanoma was achieved. The molecules that destroy cell membranes through VDA have been termed molecular jackhammers because they undergo concerted whole-molecule vibrations. Given that a cell is unlikely to develop resistance to such molecular mechanical forces, molecular jackhammers present an alternative modality for inducing cancer cell death.

© 2023. The Author(s), under exclusive licence to Springer Nature Limited.

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Observation of proton tunneling correlated with phonons and electrons in Pd

Hydrogen in materials finds various applications such as hydrogen storage and heterogeneous catalysis (1–3). Hydrogen diffusion is an elementary step for hydrogen storage and reactions and has long been studied to date. Hydrogen, as the lightest and smallest atom, manifests nuclear quantum effects including the zero-point vibration, discrete vibrational energy levels, and quantum tunneling (4). These quantum effects are believed to have a substantial impact on diffusion at low temperatures.

The interaction of hydrogen with surroundings such as phonons and electrons of host materials can be crucial for the hydrogen tunneling. It has been theoretically suggested that whereas phonon effects associated with lattice deformation bring about a positive temperature dependence in the tunneling rate, the effect of nonadiabatic electron-hole pair excitation due to the presence of the Fermi surface causes a slightly negative temperature dependence in metals (5–10). From an experimental viewpoint, however, such temperature-dependent tunneling was rarely observed except for some cases of H on metal surfaces (11–19). As for three-dimensional systems, the tunneling was only mimicked by muon, a light isotope with about one-ninth the mass of H, in the spin relaxation experiments in simple metals (20–23). Detailed experimental data of the temperature-dependent hydrogen hopping rate at low temperatures in materials are still lacking to comprehensively elucidate the quantum nature of hydrogen.

Absorbed hydrogen in metals occupies interstitial lattice locations. Figure 1A illustrates the face-centered cubic (fcc) lattice structure, where tetrahedral (T) and/or octahedral (O) sites are preferred by hydrogen. Hydrogen atoms are known to thermally diffuse between stable sites via a metastable site at elevated temperatures. At low temperature, the quantum nature appears, and the tunneling between them might also play a decisive role. Although it is recognized that the potential shape is crucial for the tunneling rate (24), the influence of the interaction with surroundings on the tunneling in an asymmetric potential between inequivalent sites such as the stable and metastable sites has hardly been considered even theoretically (25). In this regard, experimental identification of the hopping pathway is also important to address the quantum nature of hydrogen.

Richard Feynman Lecture — “Los Alamos From Below”

There are quite a few copies of this Feynman lecture floating around out there, but most end prior to the question from the audience.

After the lecture, a guy in the audience asks Feynman about his safe-cracking stories and Feynman goes on for about another ten minutes relating three different stories on his safe-cracking while at Los Alamos National Laboratories. Enjoy!

Automated Benchtop Synthesis of a Quadrillion-Plus Member Core@Multishell Nanoparticle Library Using a Massively Generalizable Nanochemical Reaction

Rapidly expanding advances in computational prediction capabilities have led to the identification of many potential materials that were previously unknown, including millions of solid-state compounds and hundreds of nanoparticles with complex compositions and morphologies. Autonomous workflows are being developed to accelerate experimental validation of these bulk and nanoscale materials through synthesis. For colloidal nanoparticles, such strategies have focused primarily on compositionally simple systems, due in part to limitations in the generalizability of chemical reactions and incompatibilities between automated setups and mainstream laboratory methods. As a result, the scope of theoretical versus synthesizable materials is rapidly diverging. Here, we use a simple automated platform to drive a massively generalizable reaction capable of producing more than 651 quadrillion distinct core@multishell nanoparticles using a single set of reaction conditions. As a strategic model system, we chose a family of seven isostructural layered rare earth (RE) oxychloride compounds, REOCl (RE = La, Ce, Pr, Nd, Sm, Gd, Dy), which are well-known 2D materials with composition-dependent optical, electronic, and catalytic properties. By integrating a computer-driven, hobbyist-level pump system with a laboratory-scale synthesis setup, we could grow up to 20 REOCl shells in any sequence on a REOCl nanoparticle core. Reagent injection sequences were programmed to introduce composition gradients, luminescent dopants, and binary through high-entropy solid solutions, which expands the library to a near-infinite scope. We also used ChatGPT to randomly select several core@multishell nanoparticle targets within predefined constraints and then direct the automated setup to synthesize them. This platform, which includes both massively generalizable nanochemical reactions and laboratory-scale automated synthesis, is poised for plug-and-play integration into autonomous materials discovery workflows to expand the translation of prediction to realization through efficient synthesis.

Wedding cake contains edible chocolate batteries that power candles

This isn’t your normal wedding cake. The gummy bears on top can dance, their heads and arms moving thanks to injections of air through a pneumatic system, and the LED candles at the bottom are powered by batteries made out of chocolate. Such edible electronics have been proposed as a solution to electronic waste. The cake was unveiled at Expo 2025 in Osaka, Japan, on 13 April.

This kid-friendly 3D printing pen makes edible candy sculptures

3Doodler, known for its 3D-printing pens, has announced a kid-friendly version of its Chef 3D pen that prints with candy instead of plastic filament. The new 3Doodler Candy, arriving later this year, swaps a power cord for a 45-minute rechargeable battery and uses gluten-free vegan isomalt capsules instead of sugar.

The candy comes out of the pen at 45 degrees Fahrenheit, so it’s safe for kids aged six and up to use.

Chinese humanoid robot sets guinness world record with 106-km inter-city walk

New research shows that the magnetic part of light actively shapes how light interacts with matter, challenging a 180-year-old belief.

The team demonstrated that this magnetic component significantly contributes to the Faraday Effect, even accounting for up to 70% of the rotation in the infrared range. By proving that light can magnetically torque materials, the findings open unexpected pathways for advanced optical and magnetic technologies.

Revealing Light’s Hidden Magnetic Power

Polygenic Contributions to Lithium Augmentation Outcomes in Unipolar Depression

Higher polygenic risk scores for bipolar disorder were associated with favorable treatment outcomes after lithium augmentation in antidepressant non-responders with unipolar depression.

Question Are polygenic risk scores (PRS) for major psychiatric disorders associated with favorable treatment outcomes after lithium augmentation (LA) in major depression?

Findings In this cohort study with 193 patients with major depressive disorder (MDD) who did not respond to antidepressants, the PRS for bipolar disorder (BIP) was significantly associated with response and remission after at least 4 weeks of LA. Additionally, we found an association between the MDD-PRS and LA response.

Meaning Individuals with a higher polygenic burden for BIP and lower polygenic burden for MDD are more likely to experience favorable treatment outcomes following LA, offering new opportunities for personalized medicine approaches.

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