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RPG dev pushes back against Steam review AI accusations: ‘We poured years of our lives into this game and only worked with real human artists on everything’

The ubiquity of generative AI is a hard pill to swallow, but even harder is figuring out what’s AI and isn’t. It’s easier than ever now to reach for that low-hanging fruit of critique in saying that something looks like an AI spat it out, especially now that games are claiming they were, in fact, spat out entirely by AI. Positive Concept Games, the developer of SNES-esque RPG Shrine’s Legacy, found that out the hard way, as it shared in a post on X last Wednesday.

Please don’t do this. We poured years of our lives into this game and only worked with real human artists on everything: From the writing to the coding, all work was done by human hands. We do not endorse generative AI and will never use it. pic.twitter.com/3L7NKVX1L8 December 10, 2025

The dev shared a Steam review of the game that calls it “AI slop,” claims the “story is dogshit mixed with catshit,” and reiterates that the game was “made in CHAT GPT.” The developer caption reads: “Please don’t do this. We poured years of our lives into this game and only worked with real human artists on everything … We do not endorse generative AI and will never use it.”

Gray-Scale Median in Patients with Symptomatic and Asymptomatic Carotid Atherosclerosis—Risk Factors and Diagnostic Potential

Background: The identification of clinical factors affecting the gray-scale median (GSM) and determination of GSM diagnostic utility for differentiating between symptomatic and asymptomatic internal carotid artery (ICA) stenosis. Methods: This study included 45 patients with asymptomatic and 40 patients with symptomatic ICA stenosis undergoing carotid endarterectomy (CEA). Echolucency of carotid plaque was determined using computerized techniques for the GSM analysis. Study groups were compared in terms of clinical risk factors, coexisting comorbidities, and used pharmacotherapy. Results: Mean GSM values in the symptomatic group were significantly lower than in the asymptomatic group (p < 0.001). Both in the univariate as well as in the multiple regression analysis, GSM was significantly correlated with D-dimers and fasting plasma glucose levels and tended to correlate with β-adrenoceptor antagonist use in the symptomatic group. In asymptomatic patients, GSM was associated with the presence of grade 2 and grade 3 hypertension, and tended to correlate with the use of metformin, sulfonylureas, and statin. Independent factors for GSM in this group remained as grade 3 hypertension and statin’s therapy. The receiver operating characteristic (ROC) analysis revealed that GSM differentiated symptomatic from asymptomatic ICA stenosis with sensitivity and specificity of 73% and 80%, respectively. Conclusion: The completely diverse clinical parameters may affect GSM in symptomatic and asymptomatic patients undergoing CEA, whose clinical characteristics were similar in terms of most of the compared parameters. GSM may be a clinically useful parameter for differentiating between symptomatic and asymptomatic ICA stenosis.

At 92 He is Testing a Mitochondrial Transplant That Could Rewrite Aging | Dr John Cramer

Dr. John Cramer, 92-year-old nuclear physicist, discusses participating in the first mitochondrial transplant trial for aging and his longevity theory.
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Dr. John Cramer is a 92-year-old emeritus professor at the University of Washington who has spent decades researching nuclear physics and quantum mechanics. Now, he’s turned his attention to longevity, and he’s not just theorizing. Dr. Cramer is participating in Mitrix’s groundbreaking mitochondrial transplantation trial, which aims to replace damaged mitochondrial DNA with healthy versions grown in bioreactors.

In this conversation, Dr. Cramer explains why he believes mitochondrial dysfunction is the root cause of aging, not just another hallmark. He discusses how energy depletion cascades into all other aging symptoms, why previous interventions like telomere extension haven’t delivered, and what markers will be tracked throughout his trial. He also shares his personal longevity protocol, including rapamycin, senolytics, and hyperbaric oxygen therapy.

This is one of the first detailed discussions of autologous mitochondrial transplantation for aging in humans.

Continue reading “At 92 He is Testing a Mitochondrial Transplant That Could Rewrite Aging | Dr John Cramer” | >

Rise of the machines: From AI to AGI to the uncharted realm of Superintelligence

AI’s rise to fame in the mainstream happened with OpenAI’s GPT-3 launch in 2020, which became a benchmark for large language models and quickly spread through startups via APIs. While Big Tech now races toward AGI and superintelligence, experts warn current systems remain limited, governance unprepared, and safety oversight crucial as AI capabilities accelerate faster than human control.

NDR2 regulates non-small cell lung cancer cell migration under starvation by supporting autophagosome biogenesis through LC3 and ATG9A regulation

Biojout, T., Bergot, E., Taylor, J. et al. Cell Death Discov. (2025). https://doi.org/10.1038/s41420-025-02889-9

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