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Researchers at NIMTE have turned metal corrosion into a tool for efficient biomass upgrading, achieving high HMF-to-BHMF conversion rates with a CoCuMW/CF electrode. Their findings offer a low-cost, sustainable solution for bio-based chemical production.

A research team led by Prof. Jian Zhang from the Ningbo Institute of Materials Technology and Engineering (NIMTE) of the Chinese Academy of Sciences (CAS) has harnessed metal corrosion to develop high-performance electrodes, facilitating the efficient and cost-effective upgrading of bio-based 5-hydroxymethylfurfural (HMF). Their findings were published in Chem Catalysis.

While corrosion is typically associated with material degradation and economic loss, researchers are now investigating its potential for advantageous applications, particularly in biomass upgrading.

A strange molecular pattern, first mistaken for an error, led researchers to an unexpected discovery: molecules forming non-repeating structures similar to the einstein tiling problem.

This phenomenon, driven by chirality and energy balance, could pave the way for novel insights into molecular physics.

At the crossroads of mathematics and tiling lies the einstein problem—a puzzle that, despite its name, has nothing to do with Albert Einstein. The question is simple yet profound: Can a single shape tile an infinite surface without ever creating a repeating pattern? In 2022, English amateur mathematician David Smith discovered such a shape, known as a “proto-tile.”

Startlingly thorough discussion of the changes underway in spaceflight.


This week on NewsNight, the Trump administration’s shake-up of government leads to changes at NASA. The panel looks at the president’s call for an expedited timetable for getting astronauts to Mars, and how cuts to federal spending might affect the space agency. Plus, Governor DeSantis floats relocating NASA headquarters to Florida.

#florida #nasa #space #artemis #trump #spacex.

MIT researchers developed a new approach for assessing predictions with a spatial dimension, like forecasting weather or mapping air pollution.

Re relying on a weather app to predict next week’s temperature. How do you know you can trust its forecast? Scientists use statistical and physical models to make predictions about everything from weather to air pollution. But checking whether these models are truly reliable is trickier than it seems—especially when the locations where we have validation data don Traditional validation methods struggle with this problem, failing to provide consistent accuracy in real-world scenarios. In this work, researchers introduce a new validation approach designed to improve trust in spatial predictions. They define a key requirement: as more validation data becomes available, the accuracy of the validation method should improve indefinitely. They show that existing methods don’t always meet this standard. Instead, they propose an approach inspired by previous work on handling differences in data distributions (known as “covariate shift”) but adapted for spatial prediction. Their method not only meets their strict validation requirement but also outperforms existing techniques in both simulations and real-world data.

By refining how we validate predictive models, this work helps ensure that critical forecasts—like air pollution levels or extreme weather events—can be trusted with greater confidence.


A new evaluation method assesses the accuracy of spatial prediction techniques, outperforming traditional methods. This could help scientists make better predictions in areas like weather forecasting, climate research, public health, and ecological management.

Technically this year we have a global pandemic but with 11 different viruses that have evolved.


For the first time the pandemic began, deaths from influenza have outpaced deaths from COVID-19 in 22 states, plus New York City and Washington, D.C. Dr. Jon LaPook has the latest numbers.

Selective serotonin reuptake inhibitor (SSRI) antidepressants are some of the most widely prescribed drugs in the world, and new research suggests they could also protect against serious infections and life-threatening sepsis. Scientists at the Salk Institute studying a mouse model of sepsis uncovered how the SSRI fluoxetine can regulate the immune system and defend against infectious disease, and found that this protection is independent to peripheral serotonin. The findings could encourage additional research into the potential therapeutic uses of SSRIs during infection.

“When treating an infection, the optimal treatment strategy would be one that kills the bacteria or virus while also protecting our tissues and organs,” commented professor Janelle Ayres, PhD, holder of the Salk Institute Legacy Chair and Howard Hughes Medical Institute Investigator. “Most medications we have in our toolbox kill pathogens, but we were thrilled to find that fluoxetine can protect tissues and organs, too. It’s essentially playing offense and defense, which is ideal, and especially exciting to see in a drug that we already know is safe to use in humans.”

Ayres is senior author of the team’s report in Science Advances. In their paper, titled “Fluoxetine promotes IL-10–dependent metabolic defenses to protect from sepsis-induced lethality,” the investigators stated, “Our work reveals a beneficial ‘off-target’ effect of fluoxetine, and reveals a protective immunometabolic defense mechanism with therapeutic potential.”

Artificial intelligence (AI) has the potential to revolutionize the drug discovery process, offering improved efficiency, accuracy, and speed. However, the successful application of AI is dependent on the availability of high-quality data, the addressing of ethical concerns, and the recognition of the limitations of AI-based approaches. In this article, the benefits, challenges, and drawbacks of AI in this field are reviewed, and possible strategies and approaches for overcoming the present obstacles are proposed. The use of data augmentation, explainable AI, and the integration of AI with traditional experimental methods, as well as the potential advantages of AI in pharmaceutical research, are also discussed. Overall, this review highlights the potential of AI in drug discovery and provides insights into the challenges and opportunities for realizing its potential in this field.