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A Paradigm Shift in Evolutionary Biology: The Extended Evolutionary Synthesis and the Role of Epigenetics

The field of evolutionary biology has a rich and complex history, marked by periods of consensus and significant theoretical shifts. The cornerstone of modern evolutionary thought for much of the 20th century was the Modern Synthesis (MS), a theoretical framework that integrated Darwin’s theory of natural selection with Mendelian genetics.

It provided a powerful and elegant explanation for how evolution occurs, emphasizing the gradual accumulation of genetic mutations and their differential survival in a population. However, in recent decades, a growing body of evidence has begun to challenge the sufficiency of the MS, leading to the development of a new, more comprehensive framework: the Extended Evolutionary Synthesis (EES).

Researchers uncover dozens of traits driven by maternal versus paternal genes

Researchers developed a high-accuracy method to infer whether genetic variants come from the mother or father without needing parental genomes, analysing 286,666 UK Biobank participants. They uncovered over 30 parent-of-origin effects on traits from growth and metabolism to diabetes, many showing opposite effects depending on parental source.

Stem Cell Therapy Offers Hope for Repairing Brain Damage in Newborns

Oxygen deprivation around birth can lead to brain damage in babies, with far-reaching consequences. A new stem cell treatment administered via nasal drops is showing promising results. In a safety study conducted at UMC Utrecht, called PASSIoN, ten newborns received this ‘intranasal stem cell therapy’ shortly after birth. Most of the children showed remarkably positive development: they started walking earlier on average than untreated children with comparable brain damage, had no motor impairments, and none developed epilepsy or visual problems. The study results were published today in the scientific journal Stroke.

All ten babies in the study had a perinatal stroke: a type of brain injury that occurs just before, during, or shortly after birth, damaging the developing brain. This kind of injury can lead to long-term neurological problems such as cerebral palsy (CP), a condition that affects movement due to early brain damage.

Replacing brain immune cells in mice slows neurodegeneration in Stanford Medicine study

By Krista Conger

The technique, which used genetically healthy donor cells, prolonged life and function in mice with a disease similar to Tay-Sachs. It may help with other neurodegenerative diseases like Alzheimer’s.

Liz Parrish: Why She Risked Everything on an Unproven Treatment

What would you do if medicine offered no answers?

Liz Parrish didn’t wait for FDA approval. She became the first person in the world to take multiple gene therapies, using her own body to test a future that medicine wasn’t ready for.

Since then, she’s taken 10 gene therapies, helped over 300 people treat conditions once considered untreatable, and challenged one of the biggest assumptions in healthcare:

👉 Should we treat aging the same way we treat disease?

In this talk, Liz shares how her personal decision created ripple effects across the world — and why gene therapy may be the first real step toward extending not just health span, but lifespan.

What you’ll hear:

James Dyson reveals the future of farming

How do you grow 2.5x more strawberries? James Dyson reveals how engineers designed and built a unique way to increase Dyson Farming’s strawberry output.

Strawberries available in the UK from:
@Ocado
@marksandspencer
@sainsburys

Discover more about Dyson Farming:
dysonfarming.com.
#Dyson #InsideDyson #DysonFarming

PCI-SIG Announces PCI-Express Gen 8 Specification: 256 Gbps Per Lane Per Direction, Arrives 2028

PCI-SIG today announced the PCI Express (PCIe) 8.0 specification will double the data of the PCIe 7.0 specification to 256.0 GT/s and is planned for release to members by 2028. “Following this year’s release of the PCIe 7.0 specification, PCI-SIG is excited to announce that the PCIe 8.0 specification will double the data rate to 256 GT/s, maintaining our tradition of doubling bandwidth every three years to support next-generation applications,” said Al Yanes, PCI-SIG President and Chairperson. “With the increasing data throughput required in AI and other applications, there remains a strong demand for high performance. PCIe technology will continue to deliver a cost-effective, high-bandwidth, and low-latency I/O interconnect to meet industry needs.”

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