2 Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston Massachusetts, USA.
3Cardiometabolic Trials Unit, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.
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When EGFRMutant NSCLC Becomes SCLC: Can Immunotherapy Become Relevant Again?
All included patients had histologically confirmed EGFR-mutant lung cancer followed by biopsy-proven SCLC transformation. Fifty-nine patients were identified, making this one of the larger multicenter real-world datasets examining this specific resistance phenotype.
The median age was 57.8 years, and 76.3% of patients carried an EGFR exon 19 deletion.
Most patients had initially presented with metastatic disease, and 57 of 59 had received first-line EGFR-TKI therapy. Median progression-free survival on initial EGFR-targeted therapy was 14 months, while the median interval from metastatic diagnosis to histologic SCLC transformation was 22 months.
Human model of childhood dementia from drug screen and AI
In a new study published in the prestigious Nature Communications journal, medical researchers used patient-derived brain cells grown in the lab, combined with advanced imaging and artificial intelligence, to rapidly test approved drugs and pinpoint those that improve brain cell health.
The research focused on Sanfilippo syndrome, a devastating childhood dementia that causes progressive loss of memory, behavior and physical abilities. There are currently no widely available treatments.
Sanfilippo syndrome is one of more than 100 genetic disorders that together affect 1 in 2900 children in Australia and half of all children with dementia die by the age of ten.
Gramscale bottomup flash graphene synthesis
Simple trash can be turned into the quantum material graphene which could make future cities or even new computers and so much more.
Flash Joule heating of inexpensive carbon sources is used to produce gram-scale quantities of high-quality graphene in under a second, without the need for a furnace, solvents or reactive gases.
Penrose’s theory of consciousness supported by new quantum evidence
Roger Penrose argued that human thought does things no computer can, so the mind must make use of non-computable quantum mechanics. The idea remains fringe. Most scientists think that in warm, wet environments like the brain, quantum states collapse into classical states far faster than neurons fire, and so cognition must be governed by classical physics. But neuroscientist Mike Wiest argues that new evidence challenges this assumption: stable quantum states are now being observed at far higher temperatures than previously thought possible. And consciousness, he suggests, has structural features that make quantum mechanics a natural place to look for an explanation, so critics should stop accusing Penrose of simply piling one mystery on top of another. The time has come to give this neglected proposal another look. I.
Smart probiotics can sense high blood sugar and release GLP-1 on demand
In a recent study published in Nature, scientists from the Shanghai Academy of Natural Sciences (SANS) in China developed an oral living drug, GIFT, made from engineered probiotic bacteria. The bacteria carry a built-in molecular glucose sensor, created using a gene circuit controlled by a sensor protein called HexR.