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‘Proust’s madeleine’ finally explained by neuroscience

A team of CNRS scientists has pinpointed the brain mechanisms behind the famous “Proust’s madeleine” phenomenon, in which smells bring back vivid, emotional memories.

This work, published in PLOS Biology on July 14, 2026, shows that early-life olfactory experiences leave a lasting impression on the brain, capable of reactivating the context and emotions associated with that memory throughout our lives.

The neuroscientists revealed the central role played by neurons in the olfactory bulb, an area of the brain that continues to develop during childhood. When these neurons are reactivated in adulthood by odors we experienced in childhood, they activate cerebral circuits involved in both memory and reward.

Effective treatment of glioblastoma requires crossing the blood–brain barrier and targeting tumors including cancer stem cells: The promise of nanomedicine

Glioblastoma multiforme (GBM) is the most aggressive and lethal type of brain tumor. Both therapeutic resistance and restricted permeation of drugs across the blood–brain barrier (BBB) play a major role in the poor prognosis of GBM patients. Accumulated evidence suggests that in many human cancers, including GBM, therapeutic resistance can be attributed to a small fraction of cancer cells known as cancer stem cells (CSCs). CSCs have been shown to have stem cell-like properties that enable them to evade traditional cytotoxic therapies, and so new CSC-directed anti-cancer therapies are needed. Nanoparticles have been designed to selectively deliver payloads to relevant target cells in the body, and there is considerable interest in the use of nanoparticles for CSC-directed anti-cancer therapies.

Scientists identify fructose as a surprise driver of cancer spread

A new study from The Wistar Institute has uncovered an unexpected link between fructose—a common dietary sugar—and the spread of an aggressive form of ovarian cancer. Published in Nature Aging, the study found that cancer cells not killed by chemotherapy send signals to neighboring tumor cells, helping them become more capable of spreading.

The researchers identified fructose as a key messenger in this process, revealing a previously unrecognized way that treatment-surviving cancer cells may promote the spread of cancer.

“Some cancer cells that survive chemotherapy aren’t dividing anymore, but they’re still biologically active,” said Aidan Cole, a postdoctoral fellow in the lab of Katherine Aird at The Wistar Institute and first author of the study. “Instead, they continue to release molecules that send signals to nearby cells. Our study is among the first to show that a nutrient—in this case, fructose—can act as one of those signals.”

Rethinking how AI supports investment decisions

Artificial intelligence (AI) is rapidly transforming modern finance, powering applications ranging from stock market forecasting to investment advice. But does making more accurate predictions necessarily lead to better investment decisions? According to two recent studies by researchers from Pusan National University and international collaborators, the answer may be no.

Just as a weather app may predict tomorrow’s temperature accurately but still tell you to leave your umbrella at home before a storm, a financial AI system can make highly accurate market forecasts yet still make poor investment decisions. The researchers argue that AI should be judged not only by how well it predicts markets but also by how effectively it supports real-world financial decisions.

All living things emit a faint glow. Could this light be useful?

An interesting report on the phenomenon by which cells and organisms glow very faintly, primarily due to energy transitions during aerobic respiration. Speculation on biological functions and future applications are covered.

Ultra-weak ‘biophotons’ might be used to diagnose disease, or could even represent a new signalling mechanism in cells.

Researchers Simulate Alzheimer’s Progression Across the Entire Brain

This hypothesis has led to a new “whole-brain” mathematical and computational model developed at the MOX Laboratory of the Department of Mathematics of Politecnico di Milano. The model is designed to describe in an integrated way the interaction between the spread of amyloid beta and the functioning of the cerebral vascular network. The aim is to provide a tool capable of simulating, on the scale of the whole organ, how small biological or vascular alterations can evolve over time and contribute to neurodegeneration. The model and the accompanying scientific study have been published in the prestigious scientific journal Computer Methods in Applied Mechanics and Engineering.

The model integrates two scales of analysis. On the one hand, it describes the dynamics of the production, transformation, diffusion and elimination of the healthy and pathological forms of amyloid beta. On the other, it describes blood flow through a “macroscopic” description of arteries, capillaries and veins, treating brain tissue as a porous medium perfused by blood vessels, through a macroscopic compartmental model. The two components are then connected to represent the possible mechanism of mutual reinforcement between protein accumulation and vascular dysfunction.

The simulations show a particularly relevant result: the brain can evolve into different states depending on the initial conditions. Small localised amounts of amyloid beta can be eliminated, allowing the system to return to a healthy state. Conversely, larger amounts can trigger a self-sustained spread of the pathology at brain scale.

Photonic time crystals unlock ultrafast control of light in the terahertz range

An international team of researchers from École Polytechnique, Collège de France and Helmholtz-Zentrum Dresden-Rossendorf (HZDR) has achieved a world first: the experimental realization of an all-optical photonic time crystal (PTC), a material whose optical properties can be strongly and periodically modulated over ultrafast timescales.

Published in Nature, this breakthrough uses HZDR’s TELBE superradiant terahertz source to drive the system into a new regime of light-matter interaction in the terahertz range. This discovery paves the way for ultrafast optical computing, new telecommunications systems and eventually new types of terahertz lasers.

Shaping the properties of light as it interacts with materials is the foundation of many discoveries and technological advances, including optical fibers for telecommunications, lasers as light sources and sensors for chemistry and biology.

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