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Serotonin receptor signaling insights may pave way for next-gen mental health drugs

In a discovery that could guide the development of next-generation antidepressants and antipsychotic medications, researchers at the Icahn School of Medicine at Mount Sinai have developed new insights into how a critical brain receptor works at the molecular level and why that matters for mental health treatments.

The study, published in the online issue of Science Advances, focuses on the 5-HT1A , a major player in regulating mood and a common target of both traditional antidepressants and newer therapies such as psychedelics. The paper is titled “Structural determinants of G protein subtype selectivity at the serotonin receptor 5-HT1A.”

Despite its clinical importance, this receptor has remained poorly understood, with many of its molecular and pharmacological properties largely understudied—until now.

The hidden mental health cost of climate distress

A new Stanford-led study sheds light on “an emerging psychological health crisis” that disproportionately affects girls. Published July 30 in The Lancet Planetary Health, the study is among the first to quantify how repeated climate stressors impact the psychological well-being and future outlook of adolescents in low-resource settings.

Researchers from Stanford’s schools of Medicine, Law, and Sustainability partnered with in Bangladesh to survey more than 1,000 teenagers and conduct focus groups across two regions with starkly different flood exposure.

“What we found really lifts the voices of frontline —a group whose perspectives and are so rarely investigated and communicated,” said lead author Liza Goldberg, an incoming Earth system science Ph.D. student in the Stanford Doerr School of Sustainability.

Bringing metallurgy into the 21st century: Precisely shaped metal objects provide unprecedented alloy control

Caltech scientists have developed a method to create metallic objects of a precisely specified shape and composition, giving them unprecedented control of the metallic mixtures, or alloys, they create and the enhanced properties those creations will display. Want a stent that is biocompatible and mechanically robust? How about strong but lightweight satellite components that can operate in space for decades?

Engineers develop new transparent electrode for infrared cameras

Infrared imaging helps us see things the human eye cannot. The technology—which can make visible body heat, gas leaks or water content, even through smoke or darkness—is used in military surveillance, search and rescue missions, health care applications and even in autonomous vehicles.

Superconductivity’s halo: Theoretical physicist helps map rare high-field phase

A puzzling form of superconductivity that arises only under strong magnetic fields has been mapped and explained by a research team including Andriy Nevidomskyy, professor of physics and astronomy at Rice University. Their findings, published in Science, detail how uranium ditelluride (UTe2) develops a superconducting halo under strong magnetic fields.

High-quality crystals enable new insights into structure–property relationships and multifunctionality

Researchers at Kumamoto University and Nagoya University have developed a new class of two-dimensional (2D) metal-organic frameworks (MOFs) using triptycene-based molecules, marking a breakthrough in the quest to understand and enhance the physical properties of these promising materials. The work is published in the Journal of the American Chemical Society.

Astronomers Discover Seeds of Life in Young Star’s Planet-Forming Disc

Astronomers have discovered signs of complex organic molecules, considered precursors to sugars and amino acids, within a planet-forming disc. Using the powerful Atacama Large Millimeter/submillimeter Array (ALMA), a research team led by Abubakar Fadul from the Max Planck Institute for Astronomy

It Shouldn’t Exist: Astronomers Discover a Planet Orbiting the “Wrong Way”

Most stars throughout the Universe are part of binary or multiple star systems. In these systems, a nearby companion star can make it difficult for planets to form and remain in stable orbits around just one of the stars.

A research team made up of international astrophysicists, led by Professor Man Hoi Lee from the University of Hong Kong’s Department of Earth Sciences and Department of Physics, along with MPhil student Ho Wan Cheng, has confirmed a highly unusual planetary discovery.

They identified a planet orbiting in the opposite direction of its binary stars’ movement, known as a retrograde orbit, within the nu Octantis (nu Octantis) binary system. Their work also sheds light on how the evolution of binary stars may have influenced the planet’s origin. These results have been published in the journal Nature.

First-Ever Images Capture Atoms “Wiggling” in Quantum Materials

Scientists have imaged atomic thermal vibrations for the first time, revealing hidden patterns that could redefine quantum and nano-electronic device design. Scientists studying atomic-level behavior in advanced electronic and quantum devices have successfully captured the first-ever microscopy i