A novel CRISPR-based screening method offers high throughput potential for studying extracellular vesicles.
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The E3 ligase HRD1 enhances plant antiviral immunity by targeting viral movement proteins
(K) A proposed model illustrating how the E3 ligase NbHRD1 negatively regulates viral infection in plants. Plant viruses with a TGB, BNYVV and PVX, as models, infect N. benthamiana plants, inducing the expression of NbHRD1 interacts with TGB movement proteins of BNYVV and PVX in the ER membrane. NbHRD1 triggers the ubiquitination and 26S proteasome-mediated degradation of TGB proteins, thereby suppressing viral movement to inhibit virus infection.
In (D), (G), and (J), EF1α served as an internal reference. The GFP gene was used as the indicator of viral RNA accumulation. Values are means ± SDs of three independent repeats. ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001; ns, not significant (Student’s t test).
Intestinal Epithelial Serotonin as a Novel Target for Treating Disorders of Gut-Brain Interaction and Mood
Increased serotonin in the gut epithelium is anxiolytic and anti-depressive which is mediated through vagal signaling.
Mushroom Vision Portals | Common Side Effects | adult swim
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Nobel laureate and Cambridge University alumnus Sir Demis Hassabis heralds a new era of AI drug discovery at ‘digital speed’
Nobel laureate and Cambridge alumnus Sir Demis Hassabis heralds a new era of ‘digital speed’ drug discovery
Flourishing microalgae could offset emissions as the planet heats up
Photosynthesising microbes in soil may increase their activity as temperatures rise, offsetting some of the carbon emissions expected to be released from peatland and permafrost
Serotonin functions as ‘prospective code for value’ in brain’s reward processing system
In our day-to-day lives, we’re constantly making a slew of decisions, from immediate matters to prospects on the far horizon. But the evolutionary nuts-and-bolts of how our brains weigh these numerous daily decisions and what role is played by the neurotransmitter serotonin has been shrouded in mystery.
Now, a new study led by an interdisciplinary University of Faculty of Medicine team delivers fascinating findings that potentially unravel a hidden aspect of what our nervous system’s extraordinarily complex serotonin system is really doing inside our skulls.
Published in the journal Nature, this study from a highly impactful international collaboration offers “broad implications across neuroscience, psychology, and psychiatry, enhancing our understanding of serotonin’s role in mood regulation, learning, and motivated behavior.”
The Particle That Might Explain Why Anything Exists at All
Scientists at CERN have made a groundbreaking discovery that deepens our understanding of why the Universe is made of matter and not antimatter. By analyzing an enormous trove of data from the LHC, researchers observed a subtle but significant asymmetry in the behavior of a particle called the be
The local microenvironment suppresses the synergy between irradiation and anti-PD1 therapy in breast-to-brain metastasis
Wischnewski et al. demonstrate suppressed CD8+ T cell cytotoxicity in breast cancer brain metastases, contrasting with genetically identical extracranial tumors. Neutrophils and Trem2+ macrophages drive this suppression, limiting the efficacy of combined irradiation and anti-PD1 therapy, highlighting potential therapeutic targets for brain metastases.