Lifeboat Foundation

A miniature review of.

The risk of morbidity and mortality increases exponentially with age. Chronic inflammation, accumulation of DNA damage, dysfunctional mitochondria, and increased senescent cell load are factors contributing to this. Mechanistic investigations have revealed specific pathways and processes which, proposedly, cause age-related phenotypes such as frailty, reduced physical resilience, and multi-morbidity. Among promising treatments alleviating the consequences of aging are caloric restriction and pharmacologically targeting longevity pathways such as the mechanistic target of rapamycin (mTOR), sirtuins, and anti-apoptotic pathways in senescent cells. Regulation of these pathways and processes has revealed significant health-and lifespan extending results in animal models. Nevertheless, it remains unclear if similar results translate to humans. A requirement of translation are the development of age-and morbidity associated biomarkers as longitudinal trials are difficult and not feasible, practical, nor ethical when human life span is the endpoint. Current biomarkers and the results of anti-aging intervention studies in humans will be covered within this paper. The future of clinical trials targeting aging may be phase 2 and 3 studies with larger populations if safety and tolerability of investigated medication continues not to be a hurdle for further investigations.

As age increases, so does the susceptibility to a series of chronic diseases which ultimately result in fatal endings. This is such a basic part of life that we rarely consider if there is anything we can do to postpone it. So far, the principal of “one-disease-one-treatment” has brought medical sciences far but this line of thought may soon be outdated when it comes to aging related conditions. It is like fighting a many-headed monster: If one condition is treated successfully, another emerges shortly after. This point is illustrated as eradicating the two leading causes of death (cancer and cardiovascular disease) extends mean life span by 3.3 and 4 years, respectively (Arias et al., 2013). Interestingly, the gain of treating multiple diseases combined exceeds the sum of these numbers.

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Put your coding skills to the test as you work your way through multiple rounds of algorithmic coding puzzles for the title of Code Jam Champ and 15,000 USD.

I’m trying to recall a sci-fi short story that I once read, about a spacecraft that’s attempting to travel farther from Earth than anyone ever has before. As it gets farther away, the crew start to experience unexplained psychological and neurological symptoms. One by one, they eventually become catatonic and need to be cared for in the ship’s infirmary, while their crewmates desperately try to determine the cause.

The protagonist is the last person to be affected, and just as they are starting to succumb, they come up with a theory: human consciousness is not just an individual phenomenon, but is somehow dependent on the collective effect of all the other human minds on Earth. So as the ship leaves Earth’s “sphere of influence”, its passengers lose their consciousness and intelligence. Having realized this, the protagonist is barely able to program the autopilot to turn around, and the narration describes their descent into insanity and subsequent return to consciousness.

The title might have contained a reference to “closeness”, “distance”, “solitude”, “togetherness”, or something along those lines. I have a vague sense that the theme and style reminded me of David Brin’s work, but having looked through his bibliography, I don’t think it’s one of his stories.

https://www.youtube.com/watch?v=HkVFB46OH1M

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You are on the PRO Robots channel and in this video we present the March 2022 news digest. The largest exhibition of technology Expo 2022 in Dubai, artificial intelligence that will replace programmers, new Atlas robot arms, an emotional android and opening of the GigaFactory Berlin by Elon Musk. All the most interesting news from the world of high-tech in one issue!

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Standard image sensors, like the billion or so already installed in practically every smartphone in use today, capture light intensity and color. Relying on common, off-the-shelf sensor technology—known as CMOS—these cameras have grown smaller and more powerful by the year and now offer tens-of-megapixels resolution. But they’ve still seen in only two dimensions, capturing images that are flat, like a drawing—until now.

Researchers at Stanford University have created a new approach that allows standard image sensors to see light in three dimensions. That is, these common cameras could soon be used to measure the distance to objects.

The engineering possibilities are dramatic. Measuring distance between objects with light is currently possible only with specialized and expensive lidar —short for “light detection and ranging”—systems. If you’ve seen a self-driving car tooling around, you can spot it right off by the hunchback of technology mounted to the roof. Most of that gear is the car’s lidar crash-avoidance system, which uses lasers to determine distances between objects.

How the modern world arose from imaginary numbers.

Scientists have created synthetic organisms that can self-replicate. Known as “Xenobots,” these tiny millimeter-wide biological machines now have the ability to reproduce — a striking leap forward in synthetic biology.

Published in the Proceedings of the National Academy of Sciences 0, a joint team from the University of Vermont, Tufts University, and Harvard University used Xenopus laevis frog embryonic cells to construct the Xenobots.

Their original work began in 2020 when the Xenobots were first “built.” The team designed an algorithm that assembled countless cells together to construct various biological machines, eventually settling on embryonic skin cells from frogs.

It’s online and it’s free (via zoom). It will be fun & exciting — I hope you can all make it. Many of the synopses of coming talks are already online (linked to from the agenda) — so check them out.