Lifeboat Foundation

For centuries, people have been using mindfulness meditation to try to relieve their pain, but neuroscientists have only recently been able to test if and how this actually works. In the latest of these efforts, researchers at University of California San Diego School of Medicine measured the effects of mindfulness on pain perception and brain activity.

The study, published July 7, 2022 in Pain, showed that mindfulness meditation interrupted the communication between brain areas involved in pain sensation and those that produce the sense of self. In the proposed mechanism, pain signals still move from the body to the brain, but the individual does not feel as much ownership over those pain sensations, so their pain and suffering are reduced.

“One of the central tenets of mindfulness is the principle that you are not your experiences,” said senior author Fadel Zeidan, Ph.D., associate professor of anesthesiology at UC San Diego School of Medicine. “You train yourself to experience thoughts and sensations without attaching your ego or sense of self to them, and we’re now finally seeing how this plays out in the brain during the experience of acute pain.”

Elon Musk announced he will walk away from his tumultuous $44 billion offer to buy Twitter, leaving the deal on the verge of collapse. The Tesla CEO sent a letter to Twitter’s board Friday saying he is terminating the acquisition.

But Twitter isn’t accepting Musk’s declaration. The chair of Twitter’s board, Bret Taylor, tweeted in response that the board is “committed to closing the transaction on the price and terms agreed upon with Mr. Musk and plans to pursue legal action to enforce the merger agreement. We are confident we will prevail in the Delaware Court of Chancery.”

Twitter could have pushed for a $1 billion breakup fee that Musk agreed to pay under these circumstances. Instead, it looks ready to fight to complete the deal, which the company’s board has approved and CEO Parag Agrawal has insisted he wants to consummate.

The discovery will help us understand more about the evolution of our galaxy and learn about fast-moving central stars.

For the function of many biomolecules, their three-dimensional structure is crucial. Researchers are therefore not only interested in the sequence of the individual building blocks of biomolecules, but also in their spatial structure. With the help of artificial intelligence (AI), bioinformaticians can already reliably predict the three-dimensional structure of a protein from its amino acid sequence. For RNA molecules, however, this technology is still in its infancy. Researchers at Ruhr-Universität Bochum (RUB) describe a way to use AI to reliably predict the structure of certain RNA molecules from their nucleotide sequence in the journal PLOS Computational Biology on July 7, 2022.

For the work, the teams led by Vivian Brandenburg and Professor Franz Narberhaus from the RUB Chair of Biology of Microorganisms cooperated with Professor Axel Mosig from the Bioinformatics Competence Area of the Bochum Center for Protein Diagnostics.

Curiosity is important for human development and learning and encourages an exploration for new information. New research published in the Journal of Individual Differences found that high dispositional curiosity is related to greater general knowledge, but not necessarily related to fluid intelligence.

Curiosity is important for both crystallized intelligence (i.e., one’s general knowledge) and fluid intelligence (i.e., one’s ability to reason and use novel information). “Seeking out new environments, being more attentive, and exploring more and more comprehensively might, in turn, also increase the probability of gaining new information,” explain study author Freda-Marie Hartung and colleagues. “Thus, it is plausible to assume that interindividual differences in epistemic curiosity are related to interindividual differences in general knowledge.”

Thus, the researchers were interested in how dispositional curiosity influences one’s acquisition of knowledge and how fluid intelligence affects this relationship. Hartung and her colleagues recruited 100 participants during lectures at a German University to complete a self-report questionnaire on the relevant personality traits (i.e., curiosity, conscientiousness, social anxiety). They also completed measures assessing their general knowledge (i.e., geography, history, math, natural sciences) and fluid intelligence (i.e., reasoning and memory tasks).

Older people with underactive thyroid, which is formally called hypothyroidism, may be at increased risk of developing dementia, according to a new research study published in the July 6, 2022, online issue of Neurology, the medical journal of the American Academy of Neurology. According to the find.

Deepmind enters into a partnership with the renowned British research institute “The Crick”. Together, the organizations aim to advance the use of artificial intelligence in biology and biomedicine.

Artificial intelligence is already having a direct impact on our everyday lives, for example in autonomous driving, through generative AI systems such as DALL-E 2 and Alphacode or hand tracking for VR headsets.

Beyond these direct application scenarios, AI can be a tool that accelerates science – indirectly impacting our future, but possibly on a much larger scale.

How the brain functions is still a black box: scientists aren’t even sure how many kinds of nerve cells exist in the brain. To know how the brain works, they need to know not only what types of nerve cells exist, but also how they work together. Researchers at the Salk Institute have gotten one step closer to unlocking this black box.

Using cutting-edge visualization and genetic techniques, the team uncovered a new subtype of nerve cell, or neuron, in the visual cortex. The group also detailed how the new cell and two similar neurons process images and connect to other parts of the brain. Learning how the brain analyzes visual information at such a detailed level may one day help doctors understand elements of disorders like schizophrenia and autism.

“Understanding these cell types contributes another piece to the puzzle uncovering neural circuits in the brain, circuits that will ultimately have implications for neurological disorders,” says Edward Callaway, Salk professor and senior author of the paper published December 6 in the journal Neuron.

Clinical studies have demonstrated a strong association between Alzheimer’s disease (AD) and delirium. A change to the Tau protein, which can lead to the formation of tangles in brain, is one of the hallmarks of AD pathology, and Tau phosphorylation at threonine 217 (Tau-PT217) and threonine 181 (Tau-PT181) are new plasma biomarkers that can detect early-stage AD. A clinical study led by investigators at Massachusetts General Hospital (MGH) has shown that plasma Tau-PT217 and Tau-PT181 are associated with incidence and severity of postoperative delirium. The findings are published in Annals of Surgery.

Early studies from the same research group at MGH have shown that the ratio of beta amyloid (which causes AD’s signature plaques) to Tau in cerebrospinal fluid is associated with postoperative delirium. Recent studies in other labs have reported that plasma Tau-PT181 concentration distinguishes AD dementia from other neurological disorders. Plasma levels of Tau-PT217 are associated with the changes in cerebrospinal fluid levels of Tau-PT217 and AD development.

In this current study, the team at MGH developed a novel method to measure Tau-PT217 and Tau-PT181 concentrations in plasma of patients, called nanoneedle technology, in collaboration with NanoMosaic (Woburn, MA). “The nanoneedle technology is ultrasensitive, requires a small volume, and can measure low concentrations of molecules, including Tau-PT217 and Tau-PT181,” says lead author Feng Liang, MD, Ph.D., in the Department of Anesthesia, Critical Care and Pain Medicine at MGH. “More than 20,000 nanoneedles are integrated on a silicon substrate assigned to detect one analyte. Each nanoneedle is a single molecule biosensor functionalized with antibodies,” says Liang.