Lifeboat Foundation

The problem? Our bodies aren’t big fans of foreign substances—particularly ones that trigger an undesirable immune response. What’s more, these delivery systems aren’t great with biological zip codes, often swarming the entire body instead of focusing on the treatment area. These “delivery problems” are half the battle for effective genetic medicine with few side effects.

“The biomedical community has been developing powerful molecular therapeutics, but delivering them to cells in a precise and efficient way is challenging,” said Zhang at the Broad Institute, the McGovern Institute, and MIT.

Continue reading “Surprise! Our Bodies Have Been Hiding a Trojan Horse for Gene Therapy” »

https://youtube.com/watch?v=a5w_aZfncO0

The virtual sphere of digital collaboration is growing.

And while the soon-to-be-defunct Facebook pivots to Meta’s Metaverse in a bid to pivot operations into the virtual world, Nvidia is expanding its Omniverse, designed to enhance workflows in the new media environment, according to a pre-brief of the GTC 2021 event that IE attended.

Continue reading “Nvidia’s New ‘Digital Twin’ Technology Lets You See Alternate Universes” »

Researchers in Korea succeeded in developing a core material for the next-generation neuromorphic (neural network imitation) semiconductor for the first time in the country. This is a result of a research team led by Dr. Jung-dae Kwon and Yong-hun Kim of the Department of Energy and Electronic Materials of the Korea Institute of Materials Science, together with Professor Byungjin Cho’s research team at Chungbuk National University. KIMS is a government-funded research institute under the Ministry of Science and ICT.

This new concept memtransistor uses a two-dimensional nanomaterial with a thickness of several nanometers. By reproducibly imitating the electrical plasticity of nerve synapses with more than 1,000 electrical stimulations, the researchers succeeded in obtaining a high pattern recognition rate of about 94.2% (98% of simulation-based pattern recognition rate).

Molybdenum sulfur (MoS₂), widely used as a semiconductor material, works on the principle that defects in a single crystal are moved by an external electric field, which makes it difficult to precisely control the concentration or shape of the defect. To solve the problem, the research team sequentially stacked an oxidic layer of niobium oxide (Nb₂O₅) and a molybdenum sulfur material and succeeded in developing an artificial synaptic device having a memtransistor structure with high electrical reliability by an external electric field. In addition, they have demonstrated that the resistance switching characteristics can be freely controlled by changing the thickness of the niobium oxidic layer, and that brain information related to memory and forgetting can be processed with a very low energy of 10 PJ (picojoule).

Neuroscience biweekly vol. 45 27th October — 10th November.

The brain uses a shared mechanism for combining words from a single language and for combining words from two different languages, a team of neuroscientists has discovered. Its findings indicate that language switching is natural for those who are bilingual because the brain has a mechanism that does not detect that the language has switched, allowing for a seamless transition in comprehending more than one language at once.

“Our brains are capable of engaging in multiple languages,” explains Sarah Phillips, a New York University doctoral candidate and the lead author of the paper, which appears in the journal eNeuro. “Languages may differ in what sounds they use and how they organize words to form sentences. However, all languages involve the process of combining words to express complex thoughts.”

Continue reading “NS/ AI and how the brain processes language” »

For over a decade, Israeli atmospheric water generator (AWG) company Watergen has been one of the players working to refine and grow air-to-water technology that can efficiently pull water vapor out of the air and collect it as fresh, filtered drinking water. Its previous work has focused heavily on large installations to supply communities, businesses and households, and its latest innovations shrink the water-harvesting tech into a form portable enough for overlanders, RVers, tiny home dwellers and other off-grid explorers.

The last time we ran into Watergen’s work was at CES 2,019 where it showed the Automotive AWG system. The center-console-integrated system was one of the wondrous highlights of the show, but it seemed an odd, limited use for a technology with such potential, a strange detour on a larger journey. Does the average passenger car driver really need a water tap over the cupholders?

Continue reading “Mobile H2O generator pulls drinking water from air for off-grid nomads” »

Scientists have recreated the first matter that appeared after the Big Bang in the Large Hadron Collider.

Micro-electro-mechanical devices (MEMS) are based on the integration of mechanical and electrical components on a micrometer scale. We all use them continuously in our everyday life: For example, in our mobile phones there are at least a dozen MEMS that regulate different activities ranging from motion, position, and inclination monitoring of the phone; active filters for the different transmission bands, and the microphone itself.

Even more interesting is the extreme nanoscale miniaturization of these devices (NEMS), because it offers the possibility of creating inertial, mass and force sensors with such sensitivity that they can interact with single molecules.

However, the diffusion of NEMS sensors is still limited by the high manufacturing cost of traditional silicon-based technologies. Conversely, new technologies such as 3D printing have shown that similar structures can be created at low cost and with interesting intrinsic functionalities, but to date the performance as mass sensors are poor.

Let’s take a look at a highly abstracted neuron. It’s like a tootsie roll, with a bulbous middle section flanked by two outward-reaching wrappers. One side is the input—an intricate tree that receives signals from a previous neuron. The other is the output, blasting signals to other neurons using bubble-like ships filled with chemicals, which in turn triggers an electrical response on the receiving end.

Here’s the crux: for this entire sequence to occur, the neuron has to “spike.” If, and only if, the neuron receives a high enough level of input—a nicely built-in noise reduction mechanism—the bulbous part will generate a spike that travels down the output channels to alert the next neuron.

But neurons don’t just use one spike to convey information. Rather, they spike in a time sequence. Think of it like Morse Code: the timing of when an electrical burst occurs carries a wealth of data. It’s the basis for neurons wiring up into circuits and hierarchies, allowing highly energy-efficient processing.

When sound was first incorporated into movies in the 1920s, it opened up new possibilities for filmmakers such as music and spoken dialogue. Physicists may be on the verge of a similar revolution, thanks to a new device developed at Stanford University that promises to bring an audio dimension to previously silent quantum science experiments.

In particular, it could bring sound to a common quantum science setup known as an optical lattice, which uses a crisscrossing mesh of laser beams to arrange atoms in an orderly manner resembling a crystal. This tool is commonly used to study the fundamental characteristics of solids and other phases of matter that have repeating geometries. A shortcoming of these lattices, however, is that they are silent.

“Without sound or vibration, we miss a crucial degree of freedom that exists in real materials,” said Benjamin Lev, associate professor of applied physics and of physics, who set his sights on this issue when he first came to Stanford in 2011. “It’s like making soup and forgetting the salt; it really takes the flavor out of the quantum ‘soup.’”.