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Common sleep aid blocks brain inflammation and tau buildup in Alzheimer’s model

Scientists have found that lemborexant not only increased restorative sleep in male mice but also reduced levels of toxic tau and brain inflammation. The findings suggest that targeting the brain’s orexin system may help slow Alzheimer’s progression.

Super Mega Mega Toaster prints images on your bread

The humble toaster hasn’t really changed much over the years. After all, there isn’t much you can do with a device which exists purely to brown bread. Scott van Haastrecht begs to differ, and has added another string to the toaster’s bow by creating a device that prints a different picture onto…

Preventing stalling to improve CAR-T cells’ efficacy against tumors

Chimeric antigen receptor (CAR)-T cells are a promising cancer therapy that are made from the patient’s own T cells, which are reprogrammed to fight their cancer. One of the limitations of CAR-T cell therapy is the ability of these cells to survive long enough to target the entire tumor.

Once injected back into the patient, the CAR-T cells tend to rapidly expand when they become activated by the , but eventually die off due to a natural process called activation-induced cell death.

In a study published in Science Translational Medicine, a research team discovered a way to alter CAR-T cells so they can partially avoid activation-induced cell death, which allows them to live longer and better fight off the tumor.

Repurposed cancer drugs shown to promote stroke recovery and limit brain damage

Stroke remains one of the leading causes of death, disability, increased economic burden and decreased quality of life around the world. Current stroke therapies are time-limited and largely focused on restoring blood flow, and there are few which address the secondary wave of inflammation that causes further injury in the hours and days after stroke.

A study by researchers from the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), has shown that a class of drugs, HDACi (), protects neurons and limits following stroke by altering the gene expression of microglia, the immune cells of the brain.

HDACi are currently used or being tested as treatments for certain cancers and are also being researched for neurological conditions such as Alzheimer’s disease.