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RegenxBio, a publicly-traded biotech firm, released data this week from a Phase 2 clinical trial designed to test its leading genetic therapy product in patients with bilateral wet age-related macular degeneration (AMD). AMD is characterized by abnormal growth of blood vessels in the retina, and is a leading cause of loss of vision in elderly populations globally.

ABBV-RGX-314, developed in collaboration with AbbVie, offers the potential of a one-time treatment for wet AMD and other retinal conditions, including diabetic retinopathy. This is in contrast to existing treatments which rely on repeated intraocular injections of drugs that inhibit a protein known as Vascular Endothelial Growth Factor (VEGF), a protein responsible for the formation of new retinal blood vessels.

The ABBV-RGX-314 therapy is based on a an AAV8 viral vector as a delivery system. The AAV8 platform has been genetically engineered to encode an antibody that can inhibit VEGF for the long-term.

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Most recently, 90s heartthrob and Dawson’s Creek star James Van Der Beek announced he’d been diagnosed with colorectal cancer at the age of just 47.

The rise is mysterious, but experts suspect ultra-processed foods, pollution and the over use of antibiotics could be driving microscopic cancer-causing changes in the body’s cells.

Now, a team of scientists across five nations, including at King’s College London, have been given £20 million by charities including Cancer Research UK to fund fresh studies that will begin early next year, The Times reported.

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Researchers suggest a new approach is needed to build LLMs with accurate world models.

LLMs have shown that they can excel at various things – like writing, generating computer programs, and more activities.

This can make it seem like these models are learning some general truths about the world, but the study found out otherwise.

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Researchers at Cornell have engineered a groundbreaking porous crystal using a unique fusion of macrocycle and molecular cage structures, enhancing lithium-ion transport in solid-state batteries.

This new crystal design features one-dimensional nanochannels that significantly increase ion conductivity, a development that promises safer batteries and has potential applications in water purification and bioelectronics.

By fusing two contorted molecular structures, Cornell researchers have developed a porous crystal capable of absorbing lithium-ion electrolytes and smoothly transporting them through one-dimensional nanochannels. This innovative design has the potential to enhance the safety of solid-state lithium-ion batteries.

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Besides Pokémon, there might have been no greater media franchise for a child of the 90s than the Transformers, mysterious robots fighting an intergalactic war but which can inexplicably change into various Earth-based object, like trucks and airplanes. It led to a number of toys which can also change shapes from fighting robots into various ordinary objects as well. And, perhaps in a way of life imitating art, plenty of real-life robots have features one might think were inspired by this franchise like this transforming quadruped robot.

Called the CYOBot, the robot has four articulating arms with a wheel at the end of each. The arms can be placed in a wide array of positions for different operating characteristics, allowing the robot to move in an incredibly diverse way. It’s based on a previous version called the CYOCrawler, using similar articulating arms but with no wheels. The build centers around an ESP32-S3 microcontroller, giving it plenty of compute power for things like machine learning, as well as wireless capabilities for control or access to more computing power.

Both robots are open source and modular as well, allowing a range of people to use and add on to the platform. Another perk here is that most parts are common or 3D printed, making it a fairly low barrier to entry for a platform with so many different configurations and options for expansion and development. If you prefer robots without wheels, though, we’d always recommend looking at Strandbeests for inspiration.

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The phosphatidylinositol 3-kinase (PI3K)-AKT signaling pathway is one of the most critical and extensively investigated signaling pathways. It is the central regulator of various cellular processes including cell growth, proliferation, metabolism, and survival. Hyperactivation of PI3K-AKT signaling is highly related to a significant number of human diseases, particularly cancers.

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