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A team of researchers at Northwestern University has devised a new platform for gene editing that could inform the future application of a near-limitless library of CRISPR-based therapeutics.

Using chemical design and synthesis, the team brought together the Nobel-prize winning technology with therapeutic technology born in their own lab to overcome a critical limitation of CRISPR. Specifically, the groundbreaking work provides a system to deliver the cargo required for generating the gene editing machine known as CRISPR-Cas9. The team developed a way to transform the Cas-9 protein into a spherical nucleic acid (SNA) and load it with critical components as required to access a broad range of tissue and cell types, as well as the intracellular compartments required for gene editing.

The research, published today in a paper titled, “CRISPR Spherical Nucleic Acids,” in the publication Journal of the American Chemical Society, and shows how CRISPR SNAs can be delivered across the cell membrane and into the nucleus while also retaining bioactivity and gene editing capabilities.

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Objects in our visual environment often move unpredictably and can suddenly speed up or slow down. The ability to account for acceleration when interacting with moving objects can be critical for survival. Here, we investigate how human observers track an accelerating target with their eyes and predict its time of reappearance after a temporal occlusion by making an interceptive hand movement. Before occlusion, observers smoothly tracked the accelerating target with their eyes. At the time of occlusion, observers made a predictive saccade to the location where they subsequently intercepted the target with a quick pointing movement.

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Have you ever looked up at the night sky and pondered about your very own existence? Maybe you were camping out with some friends, or all alone marvelling at the big canvas of darkness plastered with countless glowing stars. Well, you’re not alone. Looking above and contemplating the sheer immensity of the Universe is something humans have been doing since the dawn of time.

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Could human civilization eventually spread across the whole Milky Way galaxy? Could we move beyond our small, blue planet to establish colonies in the multitude of star systems out there? These questions are pretty daunting, but their (theoretical) answers were actually put forth decades ago. Roey Tzezana describes the conceptual von Neumann machine. [Directed by Eoin Duffy, narrated by Addison Anderson, music by Wesley Slover].

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Today, one of the biggest paradoxes in the universe threatens to unravel modern science: the black hole information paradox. Every object in the universe is composed of particles with unique quantum properties and even if an object is destroyed, its quantum information is never permanently deleted. But what happens to that information when an object enters a black hole? Fabio Pacucci investigates. [Directed by Artrake Studio, narrated by Addison Anderson, music by WORKPLAYWORK / Cem Misirlioglu].

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Writing in Nature Communications, a team led by Dr. Marcelo Lozada-Hidalgo based at the National Graphene Institute (NGI) used graphene as an electrode to measure both the electrical force applied on water molecules and the rate at which these break in response to such force. The researchers found that water breaks exponentially faster in response to stronger electrical forces.

The researchers believe that this fundamental understanding of interfacial water could be used to design better catalysts to generate from water. This is an important part of the U.K.’s strategy towards achieving a net zero economy. Dr. Marcelo Lozada-Hidalgo said, “We hope that the insights from this work will be of use to various communities, including physics, catalysis, and interfacial science and that it can help design better catalysts for green hydrogen production.”

A water molecule consists of a proton and a hydroxide ion. Dissociating it involves pulling these two constituent ions apart with an electrical force. In principle, the stronger one pulls the water molecule apart, the faster it should break. This important point has not been demonstrated quantitatively in experiments.

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