Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog – Page 450

From the article:

Scientists in Boston, Massachusetts have made reprogrammed stem cells from the blood of centenarians.

Centenarians offer an opportunity to study longevity. People who’ve lived to 100 have an amazing ability to bounce back from insult and injury, says George Murphy, a stem-cell biologist at the Boston University Chobanian & Avedisian School of Medicine. One centenarian he knows recovered from the 1912 Spanish flu and COVID-19, twice. One theory that explains centenarians’ robust age is that they possess a genetic makeup that protects them from diseases.

But testing that idea is a challenge. People of that age are rare, which makes blood and skin samples from them a precious resource for research. That gave Murphy and his colleagues the idea to create a bank of centenarian cells that could be shared among scientists.

Continue reading “What’s the secret to living to 100? Centenarian stem cells could offer clues” | >

Effective immunity hinges on the ability to sense infection and cellular transformation. In humans, there is a specialized molecule on the surface of cells termed MR1 allows sensing of certain small molecule metabolites derived from cellular and microbial sources; however, the breadth of metabolite sensing is unclear.

Published in PNAS, researchers at the Monash University Biomedicine Discovery Institute have identified a form of vitamin B6 bound to MR1 as a means of engaging tumor-reactive . The work involved an international collaborative team co-led by researchers from the University of Melbourne.

According to Dr. Illing, “Our findings suggest that vitamin B6 molecules displayed by MR1 represent a means for the to detect altered cellular metabolism/metabolite levels, that may distinguish ,” she said.

Read more | >

Over the past few years, some researchers have been working on alternative energy storage systems that leverage the principles of quantum mechanics. These systems, known as quantum batteries, could be more efficient and compact than conventional battery technologies, while also achieving faster charging times.

In a recent paper published in Physical Review Letters, a research group at University of Genova introduced a new spin quantum battery, a battery that leverages the spin degrees of freedom of particles to store and release energy. This battery is charged in a unique and advantageous way, without the need for an external field.

“Quantum many-body theory and non-equilibrium physics are traditional topics in the quantum condensed matter theory group led by Maura Sassetti at University of Genova,” Dario Ferraro, senior author of the paper, told Phys.org.

Read more | >

Chimeric antigen receptor T-cell (CAR-T) therapy, already approved for certain blood cancers, is generating excitement in early tests against autoimmune diseases. Designed to wipe out a whole class of immune cells, the treatment holds promise but comes with potentially serious risks.

Read more | >

The hypertension drug rilmenidine has been shown to slow down aging in worms, an effect that in humans could hypothetically help us live longer and keep us healthier in our latter years.

Previous research has shown rilmenidine mimics the effects of caloric restriction on a cellular level. Reducing available energy while maintaining nutrition within the body has been shown to extend lifespans in several animal models.

Whether this translates to human biology, or is a potential risk to our health, is a topic of ongoing debate. Finding ways to achieve the same benefits without the costs of extreme calorie cutting could lead to new ways to improve health in old age.

Read more | >

Cheng-Yen Yang, Hsiang-Wei Huang, Wenhao Chai, Zhongyu Jiang, Jenq-Neng Hwang University of Washington 2024 https://arxiv.org/abs/2411.

A tool that can…

Official repository of Adapting Segment Anything Model for Zero-Shot Visual Tracking with Motion-Aware Memory’ — yangchris11/samurai.

Read more | >

As physicists continue their struggle to find and explain the origin of dark matter, the approximately 80% of the matter in the universe that we can’t see and so far haven’t been able to detect, researchers have now proposed a model where it is produced before the Big Bang.

Their idea is that dark matter would be produced during a infinitesimally short inflationary phase when the size of the universe quickly expanded exponentially. The new model was published in Physical Review Letters by three scientists from Texas in the US.

An intriguing idea among cosmologists is that dark matter was produced through its interaction with a thermal bath of some species, and its abundance is created by “freeze-out” or “freeze-in.” In the freeze-out scenario, dark matter is in chemical equilibrium with the bath at the earliest times—the concentration of each does not change with time.

Read more | >

Memory, a fundamental aspect of human cognition and consciousness, is multifaceted and extends beyond traditional conceptualizations of mental recall. This review article explores memory through various lenses, including brain-based, body-based, and cellular mechanisms. At its core, memory involves the encoding, storage, and retrieval of information. Advances in neuroscience reveal that synaptic changes and molecular modifications, particularly in the hippocampus, are crucial for memory consolidation. Additionally, body memory, or somatic memory, highlights how sensory experiences and traumatic events are stored and influence behavior, underscoring the role of implicit memory. Multiple studies have demonstrated that memories can be encoded and stored in cells. Evidence suggests that these memories can then be transferred between individuals through organ transplantation.

Read more | >