Lifeboat Foundation

In a new study that could improve the therapeutic efficacy of deep-brain stimulation (DBS) for psychiatric disorders such as depression, a team of scientists shows that, when DBS is applied to a specific brain region, it improves patients’ cognitive control over their behavior by increasing the power of a specific low-frequency brain rhythm in their prefrontal cortex.

The findings, published April 4 in Nature Communications, suggest that the increase in “theta” rhythms, readily detectable in EEG recordings, could provide neurosurgeons and psychiatrists with the reliable, objective and rapid feedback they’ve needed to properly fine-tune the placement and “dosage” of DBS electrical stimulation. In Parkinson’s disease, where DBS has been most successful, that kind of feedback is available through a reduction in a patient’s tremors. But for depression or obsessive-compulsive disorder, symptoms can be more subtle, subjective and slowly emergent.

“This is a major step forward for psychiatric brain stimulation,” said Alik Widge, the lead and corresponding author on the paper. Widge began the work while a clinical fellow at the Picower Institute for Learning and Memory at MIT and a research fellow at Massachusetts General Hospital (MGH). He is now an Assistant Professor of Psychiatry at the University of Minnesota Medical School. “This study shows us a specific mechanism of how DBS improves patients’ brain function, which should let us better identify who can benefit and how to optimize their individual treatment.”

New underwater camera could help scientists explore unknown regions of the ocean, track pollution, or monitor the effects of climate change.

More than 95 percent of Earth’s oceans have never been observed, according to estimates by scientists, which means we have seen less of our planet’s ocean than we have the far side of the moon or the surface of Mars.

Mars is the second smallest planet in our solar system and the fourth planet from the sun. It is a dusty, cold, desert world with a very thin atmosphere. Iron oxide is prevalent in Mars’ surface resulting in its reddish color and its nickname “The Red Planet.” Mars’ name comes from the Roman god of war.

The oldest three-dimensional green algae fossil ever found dates back more than half a billion years and may reveal that plants are older than believed.

Known for its electric vehicles, Tesla Inc TSLA also has a solar power division. Customers who bought solar roofs in Florida might be thanking the company after the lingering damage of Hurricane Ian.

What Happened: Hurricane Ian hit landfall in Florida and has caused severe damage to the region. Benzinga previously reported the impact could be $258 billion in replacement costs in one region and another $149 billion in the area of Tampa Bay.

The impact could be hundreds of millions of dollars for insurance companies as well.

A new origins-based system for classifying minerals reveals the huge geochemical imprint that life has left on Earth. It could help us identify other worlds with life too.

Since the infancy of functional magnetic resonance imaging (fMRI) in 1990, people have been fascinated by the potential for brain scans to unlock the mysteries of the human mind, our behaviors and beliefs. Many breathtaking applications for brain scans have been devised, but hype often exceeds what empirical science can deliver. It’s time to ask: What’s the big picture of neuroscience and what are the limitations of brain scans?

The specific aims of any research endeavor depend on who you ask and what funding agency is involved, says Michael Spezio, associate professor of psychology, data science and neuroscience at Scripps College. Some people believe neuroscience has the potential to explain human cognition and behavior as a fully mechanistic process, ultimately debunking an “illusion of free will.” Not all neuroscientists agree that free will is a myth, but it’s a strong current these days. Neuroscience also has applications in finance, artificial intelligence, weapons research and national security.

For other researchers and funders, the specific aim of neuroscience involves focusing on medical imaging, genetics, the study of proteins (proteomics) and the study of neural connections (connectomics). As caring persons who are biological, neurological, physical, social and spiritual, we can use neuroscience to think carefully and understand our humanity and possible ways to escape some of the traps we’ve built for ourselves, says Spezio. Also, brain scans can enhance research into spirituality, mindfulness and theory of mind – the awareness of emotions, values, empathy, beliefs, intentions and mental states to explain or predict others’ behavior.

Our brains are among the most complex objects in the known universe. Deciphering how they work could bring tremendous benefits, from finding ways to treat brain diseases and neurological disorders to inspiring new forms of machine intelligence.

But a critical starting point is coming up with a parts list. While everyone knows that brains are primarily made up of neurons, there are a dazzling array of different types of these cells. That’s not to mention the various kinds of glial cells that make up the connective tissue of the brain and play a crucial supporting role.

That’s why the National Institutes of Health’s BRAIN Initiative has just announced $500 million in funding over five years for an effort to characterize and map neuronal and other types of cells across the entire human brain. The project will be spearheaded by the Allen Institute in Seattle, but involves collaborations across 17 other institutions in the US, Europe, and Japan.

Michael Levin is a biologist at Tufts University working on novel ways to understand and control complex pattern formation in biological systems. Please support this podcast by checking out our sponsors:
- Henson Shaving: https://hensonshaving.com/lex and use code LEX to get 100 free blades with your razor.
- Eight Sleep: https://www.eightsleep.com/lex to get special savings.
- LMNT: https://drinkLMNT.com/lex to get free sample pack.
- InsideTracker: https://insidetracker.com/lex to get 20% off.

EPISODE LINKS:
Michael’s Twitter: https://twitter.com/drmichaellevin.
Michael’s Website: https://drmichaellevin.org.
Michael’s Papers:
Biological Robots: https://arxiv.org/abs/2207.00880
Synthetic Organisms: https://tandfonline.com/doi/full/10.1080/19420889.2021.2005863
Limb Regeneration: https://science.org/doi/10.1126/sciadv.abj2164

Continue reading “Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325” »

BGI Genomics, in collaboration with Southwest University, the State Key Laboratory of Silkworm Genome Biology, and other partners, has constructed a high-resolution pangenome dataset representing almost the entire genomic content in a silkworm.

This research paper, providing genetic insights into artificial selection (domestication and breeding) and ecological adaptation, was published on September 24 in Nature Communications.

Previously, due to the scarcity of wild silkworms and technical limitations of former studies, many trait-associated sites were missing. This is the first research ever to digitize silkworm gene pool and create a “digital silkworm”, greatly facilitating functional genomic research, promoting precise breeding, and thus enabling additional silk use cases.