Lifeboat Foundation

Circa 2019 immortality in the human brain 🧠

Brain injuries causing chronic sensory or motor deficit, such as stroke, are among the leading causes of disability worldwide, according to the World Health Organization; furthermore, they carry heavy social and economic burdens due to decreased quality of life and need of assistance. Given the limited effectiveness of rehabilitation, novel therapeutic strategies are required to enhance functional recovery. Since cell-based approaches have emerged as an intriguing and promising strategy to promote brain repair, many efforts have been made to study the functional integration of neurons derived from pluripotent stem cells (PSCs), or fetal neurons, after grafting into the damaged host tissue. PSCs hold great promises for their clinical applications, such as cellular replacement of damaged neural tissues with autologous neurons. They also offer the possibility to create in vitro models to assess the efficacy of drugs and therapies. Notwithstanding these potential applications, PSC-derived transplanted neurons have to match the precise sub-type, positional and functional identity of the lesioned neural tissue. Thus, the requirement of highly specific and efficient differentiation protocols of PSCs in neurons with appropriate neural identity constitutes the main challenge limiting the clinical use of stem cells in the near future. In this Review, we discuss the recent advances in the derivation of telencephalic (cortical and hippocampal) neurons from PSCs, assessing specificity and efficiency of the differentiation protocols, with particular emphasis on the genetic and molecular characterization of PSC-derived neurons. Second, we address the remaining challenges for cellular replacement therapies in cortical brain injuries, focusing on electrophysiological properties, functional integration and therapeutic effects of the transplanted neurons.

Brain injuries represent a large variety of disabling pathologies. They may originate from different causes and affect distinct brain locations, leading to an enormous multiplicity of various symptoms ranging from cognitive deficits to sensorimotor disabilities. They can also result in secondary disturbances, such as epileptic foci, which occur within the lesioned and perilesional tissues (Herman, 2002). Indeed, frequently a secondary functional damage can take place in a region distant from the first insult (e.g., the hippocampus after traumatic brain injury), providing an explanation for cognitive and memory deficits arising after a brain lesion (Girgis et al., 2016). Brain injuries can have traumatic or non-traumatic etiologies, including focal brain lesions, anoxia, tumors, aneurysms, vascular malformations, encephalitis, meningitis and stroke (Teasell et al., 2007). In particular, stroke covers a vast majority of acquired brain lesions.

Even if you’re enjoying gloriously fast broadband at home wherever you live in the world, you’re still going to be a long, long way behind the new record for data transmission: an incredible 1.02 petabits per second.

That’s a million gigabits shifted down a line every single second. The record was set by a team at the National Institute of Information and Communications Technology (NICT) in Japan, transmitting the data over 51.7 kilometers (32 miles).

To put it another way, there’s enough bandwidth here to transmit not just one 8K video feed, or a hundred or a thousand 8K video feeds, but 10 million 8K video feeds simultaneously. That’s a lot of Netflix.

Life could use a more expansive genetic code in theory, but new work shows that improving on three-letter codons would be a challenge.

Circa 2019

Robust quantum energy storage devices are essential to realize powerful next-generation batteries. Herein, we provide a proof of concept for a loss-free excitonic quantum battery (EQB) by using an open quantum network model that exhibits exchange symmetries linked to its structural topology. By storing electronic excitation energy in a symmetry-protected dark state living in a decoherence-free subspace, one can protect the charged EQB from environment-induced energy losses, thereby making it a promising platform for long-term energy storage. To illustrate the key physical principles and potential functionality of this concept, we consider an open quantum network model of a para-benzene-like structure.

‘This might be a housing bubble,’ says Dallas Fed economist—here’s an exclusive look at the latest housing market analysis.

Mimicking the human body, specifically the actuators that control muscle movement, is of immense interest around the globe. In recent years, it has led to many innovations to improve robotics, prosthetic limbs and more, but creating these actuators typically involves complex processes, with expensive and hard-to-find materials.

Researchers at The University of Texas at Austin and Penn State University have created a new type of fiber that can perform like a muscle actuator, in many ways better than other options that exist today. And, most importantly, these muscle-like fibers are simple to make and recycle.

In a new paper published in Nature Nanotechnology (“Nanostructured block copolymer muscles”), the researchers showed that these fibers, which they initially discovered while working on another project, are more efficient, flexible and able to handle increased strain compared to what’s out there today. These fibers could be used in a variety of ways, including medicine and robotics.

“We’re just human, and we cannot predict what the universe is going to tell us.”

It’s the moment we have all been waiting for: The James Webb Space Telescope will make its first scientific observations of the universe in the coming weeks. The first full-color images will drop on July 12, 2022, along with spectroscopic data.

This is the crescendo moment in a scientific symphony that has been tuning up for the last two decades.

Continue reading “A new cosmic dawn: The Webb Telescope’s first color images are arriving soon” »