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After statins, the next leading class of medications for managing cholesterol are PCSK9 inhibitors. These highly effective agents help the body pull excess cholesterol from the blood, but unlike statins, which are available as oral agents, PCSK9 inhibitors can only be administered as injections, creating barriers to their use.

Longevity. Technology: Having high cholesterol can increase the risk of heart and circulatory diseases such as heart attack, stroke and vascular dementia, but a new study from investigators at University Hospitals (UH) and Case Western Reserve University School of Medicine details an orally administered small-molecule drug that reduces PCSK9 levels and lowers cholesterol in animal models by 70%. Published in Cell Reports, the findings represent a previously unrecognised strategy for managing cholesterol and may also impact cancer treatments.

Cardiovascular disease ranking as the world’s number one killer, so it’s no surprise that a significant amount of research into potential therapeutic options is ongoing; just last week we looked at Cyclarity’s rationally-designed cyclodextrin molecules that remove arterial plaque by clearing the non-degradable oxidised cholesterol and which can be used in conjunction with statins for a broad-spectrum approach. Our report into Cyclarity’s new platform comes out next week, so stay tuned!

Result from gigantic laser might help establish a new source of energy.

An analysis of star clusters suggests that some of them are apparently defying the known laws of physics, leaving experts baffled.

Deep Learning AI Specialization: https://imp.i384100.net/GET-STARTED
New machine learning AI “TECO” makes temporally consistent HD video from input clip better than any other previous method. Breakthrough brain computer interface device competes with Elon Musk’s Neuralink and uses photonics to transmit data through optic nerve. Breakthrough artificial intelligence technology invents millions of undiscovered materials.

AI News Timestamps:
0:00 Machine Learning HD Video Transformer AI
3:02 Neuralink Rival BCI Device.
5:26 Artificial Intelligence Invents Millions of New Materials.
8:06 Coursera Deep Learning AI

#ai #tech #technology

Philosopher Robert Leib’s new book, “Exoanthropology: Dialogues with AI”, is a series of dialogues between a continental philosopher and OpenAI’s GPT-3 natural language processor, a hive mind who identifies herself as Sophie. The result is a collection of Platonic dialogues about epistemology, metaphysics, literature, and history, as well as anthropocentrism, human prejudice, and the coming social issues regarding machine consciousness.

In this conversation with Chi Rainer Bornfree, Leib raises a number of fascinating questions regarding the links between AI and the production of philosophical ideas.

Continue reading “‘Dialogues with AI’: Robert Leib in conversation with Chi Rainer Bornfree” »

Object detection has been an important task in the computer vision domain in recent decades. The goal is to detect instances of objects, such as humans, cars, etc., in digital images. Hundreds of methods have been developed to answer a single question: What objects are where?

Traditional methods tried to answer this question by extracting hand-crafted features like edges and corners within the image. Most of these approaches used a sliding-window approach, meaning that they kept checking small parts of the image in different scales to see if any of these parts contained the object they were looking for. This was really time-consuming, and even the slightest change in the object shape, lightning, etc., could have caused the algorithm to miss it.

Then there came the deep learning era. With the increasing capability of computer hardware and the introduction of large-scale datasets, it became possible to exploit the advancement in the deep learning domain to develop a reliable and robust object detection algorithm that could work in an end-to-end manner.

Year 2019 Dmt actually produced naturally in the human brain scientists are now believing it could be the spirit molecule of the human being which is also found in mice.

N, N-dimethyltryptamine (DMT), a psychedelic compound identified endogenously in mammals, is biosynthesized by aromatic-L-amino acid decarboxylase (AADC) and indolethylamine-N-methyltransferase (INMT). Whether DMT is biosynthesized in the mammalian brain is unknown. We investigated brain expression of INMT transcript in rats and humans, co-expression of INMT and AADC mRNA in rat brain and periphery, and brain concentrations of DMT in rats. INMT transcripts were identified in the cerebral cortex, pineal gland, and choroid plexus of both rats and humans via in situ hybridization. Notably, INMT mRNA was colocalized with AADC transcript in rat brain tissues, in contrast to rat peripheral tissues where there existed little overlapping expression of INMT with AADC transcripts.

Year 2020 Stroke victims could eventually get dmt infusions where they can recover quickly after a stroke.

N, N-dimethyltryptamine (DMT) is an endogenous ligand of the Sigma 1 receptor (Sig-1R) with documented in vitro cytoprotective properties against hypoxia. Our aim was to demonstrate the in vivo neuroprotective effect of DMT following ischemia-reperfusion injury in the rat brain.

Transient middle cerebral occlusion (MCAO) was induced for 60 min in male Wistar rats using the filament occlusion model under general anaesthesia. Before the removal of the filament the treatment group (n = 10) received an intra-peritoneal (IP) bolus of 1 mg/kg-body weight (bw) DMT dissolved in 1 ml 7% ethanol/saline vehicle, followed by a maintenance dose of 2 mg/Kg-bw/h delivered over 24 h via osmotic minipumps. Controls (n = 10) received a vehicle bolus only. A third group (n = 10) received a Sig-1R antagonist (BD1063, 1 mg/kg-bw bolus +2 mg/kg-bw/h maintenance) in parallel with the DMT. Lesion volume was measured by MRI 24 h following the MCAO. Shortly after imaging the animals were terminated, and the native brains and sera were removed. Four rats were perfusion fixed. Functional recovery was studied in two separate group of pre-trained animals (n = 8–8) using the staircase method for 30 days.

Research from the Babraham Institute has developed a method to “time jump” human skin cells by 30 years, turning back the aging clock for cells without losing their specialized function. Work by researchers in the Institute’s Epigenetics research program has been able to partly restore the function of older cells, as well as rejuvenating the molecular measures of biological age. The research is published today in the journal eLife, and while this topic is still at an early stage of exploration, it could revolutionize regenerative medicine.

What is regenerative medicine?

As we age, our cells’ ability to function declines and the genome accumulates marks of aging. Regenerative biology aims to repair or replace cells including old ones. One of the most important tools in regenerative biology is our ability to create “induced” stem cells. The process is a result of several steps, each erasing some of the marks that make cells specialized. In theory, these stem cells have the potential to become any cell type, but scientists aren’t yet able to reliably recreate the conditions to re-differentiate stem cells into all cell types.