Posted in genetics | Leave a Comment on Reprogramming to restore youthful epigenetics of senescent nucleus pulposus cells for mitigating intervertebral disc degeneration and alleviating low back pain
Ma, W., Wang, W., Zhao, L. et al. Bone Res 13, 35 (2025). https://doi.org/10.1038/s41413-025-00416-1
Cancer patients have an increased risk of venous thromboembolism (VTE), and VTE is the second most common cause of death among them. Anticoagulation plays a key role in the treatment of cancer-associated thrombosis (CAT). Low-molecular-weight heparin (LMWH) or direct oral anticoagulants (DOACs) are effective and generally safe options for cancer-associated VTE. However, those patients have a 10–20% risk of VTE recurrence in spite of using anticoagulants. The main reasons for recurrent VTE (rVTE) can be non-compliance, inadequate dosing of anticoagulants, thrombocytopenia and malignancy progression. Despite the publication of major guidelines regarding the management of CAT, the treatment of patients with rVTE is undefined. Treatment options for rVTE include bridging to LMWH in cases of oral anticoagulants use, LMWH dose escalation, and sometimes considering inserting a vena cava filter.
Patients with end-stage kidney disease initiating dialysis have a high incidence of pulmonary embolism (PE) and substantial mortality.
This cohort study examines the incidence and outcomes of pulmonary embolism as well as anticoagulant use among patients with end-stage kidney disease initiating dialysis.
“Our successful PDR is a testament to the expertise and dedication of our team,” Starlab CEO Tim Kopra said in the statement. “This milestone confirms that our space station design is technically sound and safe for astronaut crewed operations. Now, with our partners, we shift our focus to the full-scale development of the station, including the manufacturing of critical hardware and software integration.”
The 12,000-cubic-foot (340-cubic-meter) Starlab will be fitted with a robotic arm and a set of racks for microgravity experiments to enable companies and researchers to develop new products in space. Voyager also hopes to seal a contract with NASA to host the agency’s astronauts.
Is a 1953 independently made American black-and-white science fiction/comedy film, produced by A.D. Nast, Jr., Arch Oboler, and Sidney Pink, written and directed by Arch Oboler, and starring Hans Conried, Gloria Blondell, Billy Lynn, and Edwin Max. The film was distributed by United Artists.
Directed by Arch Oboler.
Screenplay by Arch Oboler.
Hans Conried as Kerry West.
Janet Warren as Carolyn West.
Billy Lynn as Coach Trout.
Edwin Max as the Television Deliveryman.
Gloria Blondell as the Bill Collector.
Evelyn Beresford as Old Lady Motorist.
Bob Jellison as the TV Shop Owner.
Norman Field as the Doctor.
Stephen Roberts as Head Treasury Agent.
Connie Marshall as Susie.
William Phipps as Student.
Lenore Kingston as Offended Phone Operator #2
Alice Backes as Offended Phone Operator #1
Brick Sullivan as Cop.
Words of the prophet.
What happens when AI surpasses human intelligence, accelerating its own evolution beyond our control? This is the Singularity, a moment where technology reshapes the world in ways we can’t yet imagine.
Futurist Ray Kurzweil predicts that by 2045, AI will reach this point, merging with human intelligence through Brain-Computer Interfaces (BCIs) and redefining the future of civilization. But as we move closer to this reality, we must ask: Will the Singularity be humanity’s greatest leap or its greatest risk?
Chapters.
00:00 — 00:48 Intro.
00:48 — 01:51 Technological Singularity.
01:51 — 05:09 Kurzweil’s Predictions and Accuracy.
05:09 — 07:32 The Path to the Singularity.
07:32 — 08:51 Brain-Computer Interfaces (BCIs)
08:51 — 12:14 The Singularity: What Happens Next?
12:14 — 14:14 The Concerns: Are We Ready?
14:14 — 15:11 The Countdown to 2045
The countdown has already begun. Are we prepared for what’s coming?
#RayKurzweil #Singularity #AI #FutureTech #ArtificialIntelligence #BrainComputerInterface
Cells function through an intricate network of proteins, each designed for specific tasks like metabolism, tissue repair, and immune defense. These proteins are built using genetic blueprints in our DNA. A process called alternative splicing enables a single gene to generate multiple mRNA transcripts — molecules carrying genetic instructions — allowing for protein diversity.
In healthy cells, this process maintains balance. Cancer cells, however, disrupt that process to fuel their unchecked growth by disabling proteins that regulate cell proliferation.
The researchers focused on a genetic element known as a poison exon. This natural “off switch” prevents the production of certain proteins by marking their RNA messages for destruction before they can be translated. Cancer cells suppress the poison exon in a key gene called TRA2β. Without this regulation, TRA2β levels rise, promoting tumor growth and making cancer cells more aggressive.
Rutgers researchers found that increased brown fat improves longevity and exercise capacity in mice. They aim to develop a drug that replicates these benefits in humans.
Rutgers Health researchers have made discoveries about brown fat that could pave the way for helping people stay physically fit as they age.
A team from Rutgers New Jersey Medical School found that mice lacking a specific gene developed an unusually potent form of brown fat tissue, which extended lifespan and increased exercise capacity by approximately 30%. The team is now working on a drug that could replicate these effects in humans.
Dark matter could be an entire dark sector of the universe, with its own particles and forces.
By Kathryn Zurek edited by Clara Moskowitz
Have you ever stood by the sea and been overwhelmed by its vastness, by how quickly it could roll in and swallow you? Evidence suggests that we are suspended in a cosmic sea of dark matter, a mysterious substance that shapes galaxies and large structures in the universe but is transparent to photons, the carriers of the electromagnetic force. Our galactic home, the Milky Way, is submerged in dark matter, but this hidden body but does not devour us, because its forces cannot touch the regular matter we’re made of.
A collaborative team of researchers from Imperial College London and Queen Mary University of London has achieved a significant milestone in sustainable energy technology, as detailed in their latest publication in Nature Energy.
The study unveils a pioneering approach to harnessing sunlight for efficient and stable hydrogen production using cost-effective organic materials, potentially transforming the way we generate and store clean energy.
The research tackles a longstanding challenge in the development of solar-to-hydrogen systems: the instability of organic materials such as polymers and small molecules in water and the inefficiencies caused by energy losses at critical interfaces. To address this, the research team introduced a multi-layer device architecture that integrates an organic photoactive layer with a protective graphite sheet functionalized with a nickel-iron catalyst.
