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In vivo imaging of large-scale neuronal activity plays a pivotal role in unraveling the function of the brain’s circuitry. Multiphoton microscopy, a powerful tool for deep-tissue imaging, has received sustained interest in advancing its speed, field of view and imaging depth. However, to avoid thermal damage in scattering biological tissue, field of view decreases exponentially as imaging depth increases. We present a suite of innovations to optimize three-photon microscopy for large field-of-view imaging at depths unreachable by two-photon microscopy. These techniques enable us to image neuronal activities of transgenic animals expressing protein calcium sensors in a ~ 3.5-mm diameter field-of-view with single-cell resolution in the deepest cortical layer of mouse brains.

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A large field-of-view, single-cell-resolution two-and…

Research on moscovium and nihonium shows they are more reactive than flerovium and subject to notable relativistic effects, broadening our understanding of superheavy elements and their potential uses.

An international team led by scientists from GSI/FAIR in Darmstadt, Johannes Gutenberg University Mainz, and the Helmholtz Institute Mainz has successfully determined the chemical properties of the artificially produced superheavy elements moscovium and nihonium (elements 115 and 113).

Moscovium is now the heaviest element ever to be chemically studied. Their research, published in Frontiers in Chemistry, reveals that both elements are more chemically reactive than flerovium (element 114), which was previously studied at GSI/FAIR.

Continue reading “The Periodic Table Just Got Wilder: Scientists Unveil the Secrets of the Heaviest Element Ever — Moscovium” | >

Forget cold plunges. The new flex could soon be human washing machines.

According to one of Japan’s oldest newspapers, an Osaka-based shower head maker called Science has developed a contraption that’s shaped like a cockpit, fills with water when a bather sits in a seat at its center, and measures the person’s pulse and other biological data via sensors to ensure the temperature is just right. It also “projects images on the inside of [its] transparent cover to help the person feel refreshed,” says the outlet.

Dubbed “Mirai Ningen Sentakuki” (human washing machine of the future), the apparatus might never go on sale. Indeed, for now the company’s plans for it appear limited to an expo in Osaka this April, where up to eight people can experience a 15-minute-long “wash and dry” each day after first booking a reservation.

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Numbers tell a story. From your credit score to your age, metrics predict a variety of outcomes, whether it’s your likelihood to get a loan or your risk for heart disease. Now, Stanford Medicine researchers have described another telling metric — one that can predict mortality. It’s called sleep age.

Sleep age is a projected age that correlates to one’s health based on their quality of sleep. So for instance, if you analyze the sleep characteristics of dozens of 55-year-olds and average them out, you’ll have an idea of what sleep looks like at that age. For instance, someone who’s 55 and sleeps soundly through the night with good quality REM cycles could, theoretically, might have a sleep age of 45.

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In an era where AI and data are driving the scientific revolution, quantum computing technology is emerging as another game-changer in the development of new drugs and new materials.

Dr. Hyang-Tag Lim’s research team at the Center for Quantum Technology at the Korea Institute of Science and Technology (KIST) has implemented a quantum computing algorithm that can estimate interatomic bond distances and ground state energies with chemical accuracy using fewer resources than conventional methods, and has succeeded in performing accurate calculations without the need for additional quantum error mitigation techniques.

The work is published in the journal Science Advances.

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