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Mar 24, 2023

CRISPR-induced DNA reorganization for multiplexed nucleic acid detection Communications

Posted by in category: biotech/medical

Nucleic acid sensing involving CRISPR technologies is powerful but has certain limitations, such as PAM sequence requirements and limited multiplexing. Here, authors report a CRISPR-based barcoding technology which enables multiple outputs from any target sequence, based on cis-and trans-cleavage.

Mar 24, 2023

Single-atom vibrational spectroscopy now sensitive at the level of chemical bonds

Posted by in categories: chemistry, particle physics

Researchers led by Prof. Zhou Wu from the University of Chinese Academy of Sciences (UCAS) and Prof. Sokrates T. Pantelides of Vanderbilt University have pushed the sensitivity of single-atom vibrational spectroscopy to the chemical-bonding-configuration extreme, which is critical for understanding the correlation of lattice vibrational properties with local atomic configurations in materials.

Using a combination of experimental and theoretical approaches, the researchers demonstrated the effect of chemical-bonding configurations and the atomic mass of impurity atoms on local vibrational properties at the single-atom level.

The study was published in Nature Materials.

Mar 24, 2023

Researchers develop method for deciphering positional rules in splicing

Posted by in category: biological

A research team led by Prof. Xue Yuanchao from the Institute of Biophysics of the Chinese Academy of Sciences has developed a new method for global profiling of in-situ RNA–RNA contacts associated with a specific RNA-binding protein (RBP) and revealed positional mechanisms by which PTBP1-associated RNA loops regulate cassette exon splicing.

This study was published online in Molecular Cell on March 22.

In , the same pre-mRNA can produce multiple protein isoforms to execute similar or different biological functions through . Several longstanding models proposed that RBPs may regulate alternative splicing by modulating long-range RNA–RNA interactions (RRI). However, direct experimental evidence was lacking.

Mar 24, 2023

Scientists discover easy way to make atomically-thin metal layers for new technology

Posted by in categories: energy, materials

The secret to a perfect croissant is the layers—as many as possible, each one interspersed with butter. Similarly, a new material with promise for new applications is made of many extremely thin layers of metal, between which scientists can slip different ions for various purposes. This makes them potentially very useful for future high-tech electronics or energy storage.

Until recently, these materials—known as MXenes, pronounced “max-eens”—were as labor-intensive as good croissants made in a French bakery.

But a new breakthrough by scientists with the University of Chicago shows how to make these MXenes far more quickly and easily, with fewer toxic byproducts.

Mar 24, 2023

Hyundai N Executive Wants to Put the N Vision 74 into Production

Posted by in category: futurism

The coolest concept of 2022 might become more than a concept if this VP has his way.

Mar 24, 2023

The iPhone Moment of A.I. Has Started

Posted by in categories: business, robotics/AI, supercomputing

The “iPhone moment for A.I.” hype takes many hues, but Nvidia is about the future of computing itself. NVIDIA DGX supercomputers, originally used as an AI research instrument, are now running 24/7 at businesses across the world to refine data and process AI.

While OpenAI gets a lot of the glory, I believe the credit should go to Nvidia. Launched late last year, ChatGPT went mainstream almost instantaneously, attracting over 100 million users, making it the fastest-growing application in history. “We are at the iPhone moment of AI,” Huang said. Nvidia makes about $6 to $7 Billion a fiscal quarter in revenue.

Continue reading “The iPhone Moment of A.I. Has Started” »

Mar 24, 2023

The Iron Fist Unleashed!

Posted by in category: life extension

Senescent cells accumulate with age when one senescent cell turns another cell senescent through SASP secretion. New research is offering new hope for fighting this.

Mar 24, 2023

BREAKING🚨: Scientists create the 5th form of matter for 6 minutes

Posted by in category: quantum physics

In a ground-breaking experiment, scientists have successfully created the fifth form of matter, known as the Bose-Einstein condensate (BEC), for a remarkable duration of six minutes.

This major accomplishment has the potential to revolutionize our understanding of quantum mechanics and open the door to new technological advancements. In this article, we will explore the significance of this achievement, the nature of BECs, and the potential applications of this newfound knowledge.

Mar 23, 2023

Arthur C Clarke predicting the future in 1964

Posted by in category: futurism

Clip from 1964 BBC Horizon program.

Mar 23, 2023

DNA Double Helix Splits Due to Invasive Nature of Unzipping Process

Posted by in category: biotech/medical

Scientists had a hard time reconstructing how complex molecular parts are being held together. However, that was before SISSA’s Cristian Micheletti and his team studied how the DNA double helix unzips when translocated at high velocity through a nanopore.

DNA Double Helix’s Unzipping

Continue reading “DNA Double Helix Splits Due to Invasive Nature of Unzipping Process” »

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