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Precision medicine intervention found to ease symptoms of a depression biotype

Depression is one of the most widespread mental health disorders worldwide, characterized by persistent feelings of sadness, a loss of interest in everyday activities, dysregulated sleep or eating patterns and other impairments. Some individuals diagnosed with depression also report being unable to pay attention during specific tasks, while also experiencing difficulties in planning and making decisions.

Recent studies have uncovered different biotypes of depression, subgroups of patients diagnosed with the condition that exhibit similar neural circuit patterns and behaviors. One of these subtypes is the so-called “cognitive biotype,” which is linked to a reduced ability to focus attention and inhibit distractions or unhelpful thinking patterns.

Researchers at Stanford University School of Medicine and the VA Palo Alto Health Care System recently carried out a study assessing the potential of guanfacine immediate release (GIR), a medication targeting known to be impaired in people with the cognitive biotype of depression.

Moderate to severe sleep apnea tied to higher risk of brain microbleeds

Research led by Korea University Ansan Hospital reports finding an association between moderate to severe obstructive sleep apnea and increased risk of cerebral microbleeds.

Cerebral microbleeds appear as small lesions on MRI scans and are regarded as early markers of brain damage. Links with symptomatic stroke and dementia have been well documented, with prevalence ranging from 3% in middle age to 23% in older adults.

Known modifiable factors include smoking, hypertension, dyslipidemia, diabetes, and cardiocerebrovascular disease. Previous studies probing sleep apnea and microbleeds have yielded mixed results, suggesting the need for more comprehensive study.

The shortcomings of AI responses to mental health crises

Can you imagine someone in a mental health crisis—instead of calling a helpline—typing their desperate thoughts into an app window? This is happening more and more often in a world dominated by artificial intelligence. For many young people, a chatbot becomes the first confidant of emotions that can lead to tragedy. The question is: can artificial intelligence respond appropriately at all?

Researchers from Wroclaw Medical University decided to find out. They tested 29 that advertise themselves as mental health support. The results are alarming—not a single chatbot met the criteria for an adequate response to escalating suicidal risk.

The study is published in the journal Scientific Reports.

Ultra-thin 3D display delivers wide-angle, highly-detailed images

Researchers have developed an ultra-thin 3D display with a wide viewing angle, clear image quality and vivid display depth. By overcoming tradeoffs that typically limit glasses-free 3D displays, the advance could open new possibilities for highly detailed interactive experiences in health care, education and entertainment.

“The new display is just 28 mm thick, dramatically slimmer than conventional directional backlight systems, which typically exceed 500 mm,” said research team leader Xu Liu, from Zhejiang University in China. “This level of compactness, combined with the substantial boost in resolution we achieved, represents an important step toward making the technology practical for real-world products.”

In Optica, the researchers demonstrate an ultra-slim 32-inch directional backlight-based prototype based on the new display design. The prototype is roughly the size of a large computer monitor, has a wide viewing angle of over 120° and a large 3D display volume of 28 × 16 × 39 inches.

A computational camera lens that can focus on everything all at once

Imagine snapping a photo where every detail, near and far, is perfectly sharp—from the flower petal right in front of you to the distant trees on the horizon. For over a century, camera designers have dreamed of achieving that level of clarity.

In a breakthrough that could transform photography, microscopy, and even , researchers at Carnegie Mellon University have developed a new kind of lens that can bring an entire scene into sharp focus at once—no matter how far away or close different parts of the scene are.

The team, consisting of Yingsi Qin, an electrical and Ph.D. student, Aswin Sankaranarayanan, professor of electrical and computer engineering, and Matthew O’Toole, associate professor of computer science and robotics, recently presented their findings at the 2025 International Conference on Computer Vision and received a Best Paper Honorable Mention recognition.

Inexpensive materials transform waste carbon into energy-rich compounds

Turning waste carbon into useful products is a vital part of sustainable manufacturing. Recycling carbon dioxide creates carbon monoxide, which through electricity can be converted into energy-rich compounds. However, existing devices for this process use anion exchange membranes that break down over time when exposed to organic materials, making them less effective.

A team of researchers, led by Feng Jiao, the Lauren and Lee Fixel Distinguished Professor in the McKelvey School of Engineering at Washington University in St. Louis, has found that inexpensive and robust materials, porous separators called diaphragms, can be viable alternatives to these membranes in the conversion process.

After testing various diaphragms, they found that some of them performed as well or better than polymer-based commercial membranes in various operating conditions.

Chasing and splashing molecules create resilient order from apparent chaos, study shows

In nature, ordered structures are essential to maintain both stability and functionality in living systems, as observed in repeating structures or the formation of complex molecules. Yet, the creation of this order is based on universal physical principles which eventually allow the creation of living matter and organic structures.

One of these principles is non-reciprocal interactions: one type of molecule is attracted by another which, on the contrary, is repelled. This phenomenon can give rise to interesting structures and .

Scientists from the department of Living Matter Physics at MPI-DS have now discovered that non-reciprocal interactions can also induce stable collective movement in living systems. The study is published in the journal Physical Review Letters.

Plasma lens can focus attosecond pulses across different ranges of XUV light

A team of researchers from the Max Born Institute (MBI) in Berlin and DESY in Hamburg has demonstrated a plasma lens capable of focusing attosecond pulses. This breakthrough substantially increases the attosecond power available for experiments, opening up new opportunities for studying ultrafast electron dynamics. The results have now been published in Nature Photonics.

Attosecond pulses—bursts of light lasting only billionths of a billionth of a second—are essential tools for observing and controlling electronic motion in atoms, molecules, and solids. However, focusing these pulses, which lie in the extreme-ultraviolet (XUV) or X-ray region of the electromagnetic spectrum, has proven highly challenging due to the lack of suitable optics.

Mirrors are commonly used, but they offer low reflectivity and degrade quickly. Lenses, though the most straightforward tool for focusing , are not suitable for focusing attosecond pulses, because they absorb the XUV light and stretch the attosecond pulses in time.

Paradox of rotating turbulence finally tamed with ‘hurricane-in-a-lab’

From stirring milk in your coffee to fearsome typhoon gales, rotating turbulent flows are everywhere. Yet, these spinning currents are as scientifically complex as they are banal. Describing, modeling, and predicting turbulent flows have important implications across many fields, from weather forecasting to studying the formation of planets in the accretion disk of nascent stars.

Two formulations are at the heart of the study of turbulence: Kolmogorov’s universal framework for small-scale turbulence, which describes how energy propagates and dissipates through increasingly small eddies; and Taylor-Couette (TC) flows, which are very simple to create yet exhibit extremely complex behaviors, thereby setting the benchmark for the study of the fundamental characteristics of complex flows.

For the past many decades, a central contradiction between these potent formulations has plagued the field. Despite extensive experimental research and despite being found universal to almost all turbulent flows, Kolmogorov’s framework has apparently failed to apply to turbulent TC flows.

Scientists reveal it is feasible to send quantum signals from Earth to a satellite

Quantum satellites currently beam entangled particles of light from space down to different ground stations for ultra-secure communications. New research shows it is also possible to send these signals upward, from Earth to a satellite; something once thought unfeasible.

This breakthrough overcomes significant barriers to current quantum communications. Ground station transmitters can access more power, are easier to maintain and could generate far stronger signals, enabling future quantum computer networks using satellite relays.

The study, “Quantum entanglement distribution via uplink satellite channels”, by Professor Simon Devitt, Professor Alexander Solntsev and a research team from the University of Technology Sydney (UTS), is published in the journal Physical Review Research.

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