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Laser tech detects colorectal cancer biomarker in minutes

What new methods can be developed to improve cancer detection in blood samples? This is what a recent study published in Nanoscale Horizons hopes to address as a team of researchers from Japan investigated a novel technique that could revolutionize cancer detection. This study has the potential to help scientists, medical professionals, and the public better understand new developments in cancer detection and the steps that can be taken to implement them.

For the study, the researchers introduced how laser-powered technology could help enhance blood-based tests traditionally used for cancer detection. The primary motivation behind the study was to address longstanding roadblocks with cancer detection, specifically regarding traditional cancer detection processes being time-consuming and lacks accuracy.

To test their new method, the researchers focused on a common biomarker of colorectal cancer, glycoprotein CEACAM-5, where they introduced beads of glycoprotein CEACAM-5 into blood plasma and used their laser-based technology to identify and measure the glycoprotein CEACAM-5. In the end, the researcher found their laser-based technology successfully identified nanoscale-sized glycoprotein CEACAM-5 within the blood plasma.

Experimental KRAS Vaccine Generates Immune Response Against Pancreatic Cancer in People at High Risk

@hopkinskimmel researchers report that an experimental vaccine targeting the most common genetic driver of pancreatic cancer safely generated durable immune responses in people at high risk for the disease. The first-in-human findings support further development of a vaccine aimed at preventing pancreatic cancer. ›

Stem Cell-Derived Brain Models Offer a New Window Into How Anesthesia Works

Newswise — Every day, hundreds of thousands of people undergo general anesthesia, trusting they’ll drift into unconsciousness and wake safely after surgery. Yet despite decades of use, scientists still don’t fully understand how anesthetic drugs reshape the brain’s electrical activity to produce unconsciousness.

Studying the brain’s response to anesthesia has been difficult: in living humans, there’s no safe way to study the brain cell by cell, and in animals, the drugs act on many different brain regions at once, making it hard to isolate where the effects arise.

Now, UCLA researchers have shown for the first time that human stem cell-derived brain assembloids — tiny, three-dimensional models that recreate simplified human brain circuits — can reproduce the electrical changes seen during general anesthesia. Their findings were just published in the British Journal of Anaesthesia.

Earth and Mars: Built from different cosmic recipes

Four and a half billion years ago, Earth and Mars were born in the rotating cloud of gas and dust that would eventually become our solar system. Yet exactly how the planets formed remains one of the most disputed questions in planetary science.

Now, researchers at the University of Copenhagen are adding new evidence to the debate. Using a novel approach, they have reconstructed the earliest stages of the planets’ formation by analyzing their chemical composition.

And the results surprised them.

Physicists who uncovered the first particle accelerator were honored with a Nobel Prize 75 years ago — their work shaped physics, medicine and even art research

Particle accelerators aren’t just for testing the Standard Model. They’re also used to diagnose and treat disease and study world history.

Novel ‘speech clock’ can estimate a person’s chronological age

A large study shows that machine-learning clocks based on speech can estimate chronological age and may also offer a window into brain aging, biological aging, cognitive health, cumulative burden, and dementia.

The new study, just published in leading international journal Science Advances, outlines that researchers have developed a “speech clock” that can estimate a person’s chronological age from hundreds of acoustic and linguistic characteristics of their speech. The difference between a person’s actual age and their speech-predicted age (called the speech age gap) was also associated with multiple independent markers of biological aging, brain health, cognition, social adversity, and dementia.

The study analyzed 2,928 Spanish-speaking participants from Argentina, Chile, Colombia, Mexico, and Peru, including healthy adults and people with mild cognitive impairment, Alzheimer’s disease, and different forms of frontotemporal dementia. Rather than looking at a single property of the voice, the researchers used machine learning to analyse hundreds of features capturing how people speak and what they say: incorporating speech rate and pauses, pitch, emotional content, vocabulary, semantic precision, and the amount and organisation of verbal output. Machine-learning models combined these features to estimate chronological age and generate an individual speech age gap.

Industrial IoT Protocol Fragmentation Hides A Real Lock-In Cost

OPC UA and MQTT Sparkplug B are now the accepted answer to industrial IoT protocol fragmentation. McKinsey estimates interoperability is required to capture around 40% of IoT’s total potential value.

But adopting both standards doesn’t end fragmentation. It relocates it to the edge gateway.

Machines still speak OPC UA. An edge gateway still has to translate that into Sparkplug B before data reaches the broker. That gateway is usually a specific vendor’s software, running specific translation logic, with mapping rules that may not be exportable.

A unified namespace built on someone else’s closed gateway is still a point of control the buyer doesn’t own.

The fix isn’t just picking the right protocols. It’s checking who owns the layer that bridges them — and requiring an exportable, documented mapping configuration before signing.

Full analysis:

#IndustrialIoT #IIoT #OPC UA #MQTT #SmartFactory

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