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Promising Anti-Aging Drug May Cause Brain Damage, Scientists Warn

The experimental drug combo dasatinib and quercetin (known for short as D+Q) is one of the most promising anti-aging therapies being developed right now.

It is not yet approved for human use, but some scientists think it has the potential to fight disease by improving how our systems clear out worn-down cells.

According to a new study, however, there might be a big problem with D+Q.

Migratory Eurasian blackbirds have longer telomere length but similar mitochondrial density than resident conspecifics

Telomeres are regarded as key markers of cellular ageing and physiological state. Oxidative stress, which can accelerate telomere shortening, is thought to increase during energetically demanding processes such as bird migration. However, their study in the context of migratory behaviour is limited. Here we compared telomere length (TL) and mitochondrial DNA copy number (mitoDNAcn) between migratory and resident Eurasian blackbirds on the island of Helgoland, a migratory stopover site. Contrary to expectations, we found migrants had longer TLs despite similar mitochondrial densities. These findings reinforce the idea that migratory individuals may possess specific physiological adaptations, such as enhanced antioxidant defences, that help preserve telomere integrity.

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