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CRISPR’s efficiency triples in lab tests with DNA-wrapped nanoparticles

With the power to rewrite the genetic code underlying countless diseases, CRISPR holds immense promise to revolutionize medicine. But until scientists can deliver its gene-editing machinery safely and efficiently into relevant cells and tissues, that promise will remain out of reach.

Now, Northwestern University chemists have unveiled a new type of nanostructure that dramatically improves CRISPR delivery and potentially extends its scope of utility.

Called lipid nanoparticle spherical nucleic acids (LNP-SNAs), these tiny structures carry the full set of CRISPR editing tools—Cas9 enzymes, guide RNA and a DNA repair template—wrapped in a dense, protective shell of DNA. Not only does this DNA coating shield its cargo, but it also dictates which organs and tissues the LNP-SNAs travel to and makes it easier for them to enter cells.

Graphene reveals electrons that behave like frictionless fluid and break textbook rules

For several decades, a central puzzle in quantum physics has remained unsolved: Could electrons behave like a perfect, frictionless fluid with electrical properties described by a universal quantum number?

This unique property of electrons has been extremely difficult to detect in any material so far because of the presence of atomic defects, impurities, and imperfections in the material.

Researchers at the Department of Physics, Indian Institute of Science (IISc), along with collaborators from the National Institute for Materials Science, Japan, have now finally detected this quantum fluid of electrons in graphene—a material consisting of a single sheet of pure carbon atoms.

Shaping future electronics with light: Experiment demonstrates ultrafast light control of ferroelectric properties

Ferroelectrics are seen as promising candidates for the electronics of tomorrow. An experiment at the world’s largest X-ray laser—the European XFEL in Schenefeld near Hamburg—now shows that their properties can be controlled with high precision at ultrafast time scales—using light.

Over 16,000 compromised servers uncovered using Secure Shell key probing method

An international research team from the Max Planck Institute (MPI) for Informatics in Saarbrücken, Germany, and the Delft University of Technology in the Netherlands has developed a method to detect compromised hosts at an internet scale by probing servers with public SSH keys previously observed in attacker operations.

This way, the team was able to identify more than 16,000 compromised hosts. Their findings have now been published at the USENIX Security Symposium 2025, where they were awarded a Distinguished Paper Award and the Internet Defense Prize.

Secure Shell (SSH) is one of the most common tools used to manage remotely. It provides a secure, encrypted channel between a client and a server, allowing users to log in, execute commands, and transfer files safely. SSH is widely used by system administrators and developers for maintaining and configuring remote systems.

Styrofoam-based hydrogen storage: New process offers safe, reusable solution

A research team affiliated with UNIST has unveiled a novel technology that enables hydrogen to be stored within polystyrene-derived materials, particularly those originating from Styrofoam. The research is published in the journal ACS Catalysis.

This advancement not only offers a solution to the low recycling rate of —less than 1%—but also makes hydrogen storage and transportation more practical and accessible, addressing the challenges associated with handling gaseous hydrogen.

Led by Professor Kwangjin An from the School of Energy and Chemical Engineering at UNIST, in collaboration with Dr. Hyuntae Sohn from KIST and Professor Jeehoon Han from POSTECH, the team successfully designed a comprehensive, closed-loop system to convert waste polystyrene into a liquid organic hydrogen carrier (LOHC). This innovative process enables efficient hydrogen storage, retrieval, and reuse.

A hidden simplicity behind how people move: Study reveals geography’s role in relocation

In a new paper, published in Nature Human Behaviour, scientists from DTU (the Technical University of Denmark) examine how geography shapes human mobility and propose a way to separate physical constraints from behavioral patterns. A result that may improve urban planning, transportation design as well as epidemiology models.

Using 36 years of detailed residential relocation data from Denmark, which covers 39 million moves, between more than three million addresses, the researchers show that when you account for the influence of geography, the likelihood of moving decreases consistently with distance. This means, roughly speaking, that if you double the distance, the likelihood of people moving there is half. In cities, however, distance matters less.

The reader would be right in thinking this result seems obvious. But from a scientific perspective, the data describing these several million moves was anything but simple.

Microscale mixing without turbulence: Scientists discover limits to information erasure in viscous fluids

In turbulent fluids, mixing of the components happens easily. However, in more viscous fluids such as those enclosed within cellular compartments, the intermixing of particles and molecules is much more challenging. As time also plays a role in such systems, the slow mixing by molecular movement is typically not sufficient and efficient stirring strategies are thus required to maintain functionality.

In the department of Living Matter Physics at MPI-DS, scientists investigated the universal physical principles underlying such mixing dynamics. They identified that allow for the optimal mixing of the system when energetic costs or are limiting factors. The paper is published in the journal Physical Review Letters.

“We found that the most effective stirring share a universal structure and are symmetric in time,” says Luca Cocconi, first author of the study. “These optimal protocols reveal a fundamental limit on how efficiently information—for example about the identity and position of particles—can be erased in such systems.”

Capturing language change through the genes

Throughout human history, there have been many instances where two populations came into contact—especially in the past few thousand years because of large-scale migrations as a consequence of conquests, colonialization, and, more recently, globalization. During these encounters, not only did populations exchange genetic material, but also cultural elements.

When populations interact, they may borrow technologies, beliefs, practices, and also, crucially, aspects of language. With this, sounds, words or grammatical patterns can be exchanged from one language to the other. For example, English borrowed “sausage” from French after the Norman conquests, while French later borrowed “sandwich” from English.

However, studying these linguistic exchanges can be challenging due to the limited historical records of human contacts, especially on a global scale. As a result, our understanding of how languages evolved over time through such interactions remains incomplete.

For the first time, scientists observed the ‘hidden swirls’ that affect the flow of sand, rocks and snow

What looks like ordinary sand, rocks or snow flowing in one direction can actually hide swirling currents that move in multiple directions beneath the surface.

When grains move in a landslide, most follow the steepest downhill path. This is the “primary flow,” where particles largely follow the herd. But some grains move sideways or swirl in hidden patterns, forming “secondary flows” that subtly influence how far and fast the material travels.

Understanding how grains move beneath the surface could help explain the physics of avalanches and landslides, and even improve how we handle everyday materials like wheat in silos or powders in pharmaceuticals.

Bon voyage: General Atomics set to ship final piece of giant battery to nuclear fusion project in France

The final section of what scientists and engineers say will be the largest and most powerful pulsed, superconducting magnet in the world has been completed at the Poway campus of San Diego-based General Atomics.

The 270,000-pound module is poised for shipment to France, where it will join six other identical sections at the ITER project—an ambitious international effort aimed at determining whether the so-far-untapped potential of as an energy source can be practical or not.

“This is a momentous achievement,” General Atomics Chief Executive Officer Neal Blue said Thursday during a news conference at the company’s Magnet Technologies Center in Poway.

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