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An OpenAI model has disproved a central conjecture in discrete geometry

Today, we share a breakthrough on the unit distance problem. Since Erdős’s original work, the prevailing belief has been that the “square grid” constructions depicted further below were essentially optimal for maximizing the number of unit-distance pairs. An internal OpenAI model has disproved this longstanding conjecture, providing an infinite family of examples that yield a polynomial improvement. The proof has been checked by a group of external mathematicians. They have also written a companion paper explaining the argument and providing further background and context for the significance of the result.

The result is also notable for how it was found. The proof came from a new general-purpose reasoning model, rather than from a system trained specifically for mathematics, scaffolded to search through proof strategies, or targeted at the unit distance problem in particular. As part of a broader effort to test whether advanced models can contribute to frontier research, we evaluated it on a collection of Erdős problems. In this case, it produced a proof resolving the open problem.

This proof is an important milestone for the math and AI communities. It marks the first time that a prominent open problem, central to a subfield of mathematics, has been solved autonomously by AI. It also demonstrates the depth of reasoning these systems now support. Mathematics provides a particularly clear testbed for reasoning: the problems are precise, potential proofs can be checked, and a long argument only works if the reasoning holds together from beginning to end. The method by which the problem was solved is also notable. The proof brings unexpected, sophisticated ideas from algebraic number theory to bear on an elementary geometric question.

A unifying model of stem cell dynamics explains age-related methylation patterns across mammals

A parsimonious model of stem cell dynamics describes how DNA methylation changes arise and propagate with age, unifying diverse epigenetic aging patterns and suggesting that stem cell dynamics are a key driver of aging across mammals.

AI atlas reveals hidden whole-body-damage caused by obesity

Obesity affects far more than metabolism and fat storage. It alters immune activity, nerve structure, and tissue organization across multiple organ systems, increasing the risk of diseases including type 2 diabetes, cardiovascular disease, stroke, neuropathy and cancer. Yet despite these systemic effects, researchers have lacked tools capable of studying disease-associated changes across the entire body in intact organisms and at high resolution.

A team led by Prof. Ali Ertürk, Director of the Institute for Biological Intelligence (iBIO) at Helmholtz Munich and Professor at the LMU, has now developed MouseMapper, a suite of foundation-model-based deep-learning algorithms designed to analyze whole-body biological imaging data. The framework automatically segments 31 organs and tissue types while quantitatively mapping nerves and immune cells throughout the body, enabling comprehensive multi-system analysis in intact mice.

“MouseMapper is built on a foundation model, which means it generalizes far beyond the data it was originally trained on,” says Ying Chen, co-first author of the study published in Nature.

Scientists predict winter weather months ahead using new method

Scientists have developed a new statistical model that predicts winter weather up to six months in advance by forecasting the behavior of the stratospheric polar vortex. [ https://www.labroots.com/trending/earth-and-the-environment/…g-method-2](https://www.labroots.com/trending/earth-and-the-environment/…g-method-2)


Can weather forecasts speed up predictions to help better prepare for inclement weather? This is what a recent study published in Journal of Geophysical Research Atmospheres hopes to address as an international team of scientists from Florida State University and China investigated a new method for providing better predictions of winter weather forecasts. This study has the potential to help sci better understand winter weather patterns and provide more in-depth and accurate predictions, enabling communities to better prepare for worst case scenarios.

This study is a secondary study in a series for this team, who published a first study also in the Journal of Geophysical Research Atmospheres focusing on the yearly weather patterns of the Northern Hemisphere stratospheric polar vortex (SPV). For this study, the researchers focused on developing a new method for predicting SPV weather patterns months in advance of the winter season.

Using a series of statistical models involving historical atmospheric data, the researchers ascertained to produce a statistical model capable of predicting winter weather patterns months in advance. In the end, the models demonstrated that forecasts could be made up to six months in advance.

How Earth recycles continents deep underground

Scientists have uncovered new evidence that Earth’s continents are continuously reworked deep beneath the surface, offering fresh insight into how continents have evolved over billions of years.

The study focuses on what happens after two continental plates collide to form major mountain ranges such as the Himalayas and the Alps. While geologists have long known that continental collisions build mountains and deform the crust, the new research shows that portions of continental crust can also be dragged deep into Earth during subduction before rising again and mixing with mantle rocks.

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