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Stephen Wolfram: computation is the universe’s OS

Mathematica creator Stephen Wolfram has spent nearly 50 years arguing that simple computational rules underlie everything from animal patterns to the laws of physics. In his 2023 TED talk, he makes the case that computation isn’t just a useful way to model the world — it’s the fundamental operating system of reality itself.

Wolfram introduces “the ruliad,” an abstract concept encompassing all possible computational processes. Space and matter, he argues, consist of discrete elements governed by simple rules. Gravity and quantum mechanics emerge from the same computational framework. The laws of physics themselves are observer-dependent, arising from our limited perspective within an infinite computational structure.

On AI, Wolfram sees large language models as demonstrating deep connections between semantic grammar and computational thinking. The Wolfram Language, he claims, bridges human conceptualization and computational power, letting people operationalize ideas directly — what he calls a “superpower” for thinking and creation.

Native postsynaptic density is a functional condensate formed via phase separation

To obtain direct evidence supporting the theory that the postsynaptic density (PSD) in neuronal synapses is formed via phase separation, Chen et al. purified and characterized the native PSD from the mouse brain. Their results demonstrate that the native PSD has characteristic features of biological condensates formed via phase separation.

The cytokine TNF is a driver of rheumatoid arthritis, but the signaling-pathway details remain incomplete

Here, Sarah Gaffen & team report on the noncanonical RNA binding protein Arid5a as an activator of TNF signaling that is elevated in human RA tissues. And in mice… its loss results in resistance to collagen-induced arthritis:

The figure shows TNF stimulation causes Arid5a accumulation in the cytoplasm in a murine stromal fibroblast cell line untreated (left) and treated (right); Arid5a (red); RPL7A (green); nuclei (blue).


1Division of Rheumatology & Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

2BIOCEV, First Faculty of Medicine, Charles University, Vestec, Czech Republic.

3School of Medicine, Tsinghua Medicine, Tsinghua University, Beijing, China.

Procrastination in adulthood linked to brain development during adolescence

Procrastination, the tendency to unnecessarily delay or put off tasks even if this will have negative consequences, is a common behavior for many people. While occasionally delaying or putting off bothersome tasks is not necessarily problematic, severe and prolonged procrastination is closely tied to some neuropsychiatric disorders, including attention-deficit/hyperactivity disorder (ADHD) and anxiety disorders.

Unveiling patterns in the brain’s structure and genetic factors linked to procrastination could help to reliably uncover this tendency to postpone tasks in affected individuals. This could in turn inform the development of preventative strategies or interventions that tackle procrastination early, before it exacerbates other underlying mental health disorders.

Researchers at the Chinese Academy of Sciences and other institutes in China recently carried out a study aimed at shedding new light on the biological and genetic roots of procrastination. Their paper, published in Molecular Psychiatry, outlines specific patterns in the brain’s structure during adolescence that are linked to procrastination in adulthood.

An organ-conformal, kirigami-structured bioelectronic patch for precise intracellular delivery

Now online! Organ-level localized delivery is a long-standing challenge, especially for gene therapy. This study establishes a universal conformality theory that enables POCKET—a kirigami-structured bioelectronic patch—to integrate seamlessly with organs and realize precise intracellular electro-delivery of therapeutics without off-target effects.

Bitly: Among adults with treatment-refractory

HER2-positive BiliaryTractCancer, zanidatamab produced sustained, meaningful clinical responses and extended survival compared to prior standards.

In patients with immunohistochemistry (IHC) 3+ tumors, response rates and overall survival were notably higher than those with IHC 2+ tumors, substantiating the use of reflex IHC testing to identify candidates for HER2-targeted therapy.

Safety remained consistent over 33 months of follow-up, and the ongoing HERIZON-BTC-302 phase 3 trial is assessing zanidatamab alongside first-line standard care in this setting.


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Measuring the quantum extent of a single molecule confined to a nanodroplet

There is no measurement that can directly observe the wave function of a quantum mechanical system, but the wave function is still enormously useful as its (complex) square represents the probability density of the system or elements of the system. But for a confined system, the wave function can be inferred.

Scientists from China have now shown that the wave function’s dependence in space can be determined for a single molecule embedded in a superfluid helium nanodroplet. Their research has been published in the journal Physical Review Letters.

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