Lifeboat Foundation: Safeguarding Humanity
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Featuring the Electro-Mechanical Brake and by-wire technology on the rear brakes, the project will also include ZF’s Integrated Brake Control and traditional front calipers, creating a ‘hybrid’ braking system of by-wire and hydraulics that offers increased flexibility to the manufacturer. The agreement will also provide significant steering technology with ZF’s Electric Recirculating Ball Steering Gear. This cutting-edge braking technology combined with traditional braking systems and innovative steering tools further solidifies ZF’s position as the industry leader in providing complete chassis solutions to its customers while providing a major customer win.

“We are all proud to see ZF’s technology leadership in the Chassis segment providing tangible value for our customers. Our goal when combining our steering, braking, dampers and actuators as well as corresponding software businesses into a single division was to create the world’s most comprehensive Chassis Solutions product and system offering,” said Peter Holdmann, Board of Management member at ZF and head of Division Chassis Solutions. “This combined center of expertise allows us to offer comprehensive solutions that integrate advanced engineering, innovative design, and cutting-edge technology to deliver unparalleled performance and safety.”

The road to the software-defined vehicle With the Electro-Mechanical Brake (EMB) as a key component of the brake-by-wire technology, ZF lays the foundation for the software-defined vehicle that will lead to new functions and features, many that emphasize safety as much as driving comfort. One such feature being explored with by-wire technology is the ability for the vehicle to autonomously brake and steer in a crash situation.

ZF’s Electro-Mechanical Brake provides premium performance for automatic emergency braking, full energy recuperation and redundant fallback options up to full automated driving for passenger car and light truck segments.

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The BCG vaccine protects against tuberculosis, but by inducing trained immunity it also protects against many more respiratory infections. International research led by Radboud University Medical Center shows how this process works. Lactate, a product of scaled-up energy production, appears to play a leading role.

The immune system protects people in two ways. Innate immunity protects us from birth against many bacteria and viruses, while adaptive immunity builds protection against individual pathogens after a prior infection. The adaptive immune system is aided by vaccines that protect us against new pathogens without having to go through an infection. In this way, vaccines contribute greatly to our health.

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Results of a large, global clinical trial spanning five continents with over 1,700 patients with bronchiectasis, published this April in the New England Journal of Medicine, demonstrated benefits of an investigational, once-a-day pill called brensocatib as a therapy for the chronic lung condition.

The clinical trial findings are important, as there are currently no FDA-approved medications for bronchiectasis, a chronic condition with persistent lung airway inflammation and infection. Bronchiectasis can often stem from various injuries to the airways causing the ‘bronchial’ tubes leading to the lungs to become permanently enlarged, and more prone to infection and chronic inflammation.

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In this Review, the authors discuss mass spectrometry (MS) imaging and spatially resolved MS approaches that are being employed in nephrology applications. They also highlight emerging MS methods and applications, as well as the integration of MS data with data from other omics approaches.

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Mitochondrial diseases affect approximately 1 in 5,000 people worldwide, causing debilitating symptoms ranging from muscle weakness to stroke-like episodes. Some of these conditions result from mutations in mitochondrial DNA (mtDNA), the genetic material housed in these organelles. For patients with the common m.3243A>G mutation, which can cause MELAS syndrome (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) and diabetes mellitus, treatments remain limited.

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Viruses are known to use the genetic machinery of the human cells they invade to make copies of themselves. As part of the process, viruses leave behind remnants throughout the genetic material (genomes) of humans. The virus-like insertions, called “transposable elements,” are snippets of genetic material even simpler than viruses that also use host cell machinery to replicate.

Nearly all these inserted elements have been silenced by our cells’ defense mechanisms over time, but a few, nicknamed “jumping genes,” can still move around the human genome like viruses. Just one, called long interspersed nuclear element 1 (LINE-1), can still move by itself.

As an element type that behaves like the retrovirus HIV, the LINE-1 “retrotransposon” is first copied into a molecule of RNA, the genetic material that partners with DNA, and then the RNA LINE-1 copy is converted back into DNA in a new place in the genome.

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