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Managing complex medication schedules could soon become as simple as taking a single capsule each day. Engineers at the University of California San Diego have developed a capsule that can be packed with multiple medications and release them at designated times throughout the day.

The advance, published in Matter, could help improve and by eliminating the need for patients to remember taking multiple drugs or doses at various times each day. It could potentially reduce the risk of missed doses or accidental overdoses.

“We want to simplify medication management with a single that is smart enough to deliver the right drug at the right dose at the right time,” said study first author Amal Abbas, who recently earned her Ph.D. in chemical engineering at the UC San Diego Jacobs School of Engineering. She spearheaded this work with Joseph Wang, a professor in the Aiiso Yufeng Li Family Department of Chemical and Nano Engineering at UC San Diego.

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When an object moves extremely fast—close to the speed of light—certain basic assumptions that we take for granted no longer apply. This is the central consequence of Albert Einstein’s special theory of relativity. The object then has a different length than when it is at rest, and time passes differently for the object than it does in the laboratory. All this has been repeatedly confirmed in experiments.

However, one interesting consequence of relativity has not yet been observed—the so-called Terrell-Penrose effect. In 1959, physicists James Terrell and Roger Penrose (Nobel laureate in 2020) independently concluded that fast-moving objects should appear rotated. However, this effect has never been demonstrated.

Now, a collaboration between TU Wien (Vienna) and the University of Vienna has succeeded for the first time in reproducing the effect using laser pulses and precision cameras—at an effective of 2 meters per second. The research is published in the journal Communications Physics.

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Myofibroblasts generate fibrotic scars after spinal cord injury (SCI). This is typically regarded as an impediment to nerve regeneration. Understanding the heterogeneous characteristics of fibrotic scars might help to develop strategies for remodeling fibrotic scars after SCI. However, the composition, origin and function of fibrotic scars have been a subject of ongoing debate in the field.

A recent study led by Profs. Dai Jianwu and Zhao Yannan from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences employed a combination of lineage tracing and single-cell RNA sequencing (scRNA-seq) to demonstrate the heterogeneous distribution, source, and function of meningeal fibroblasts and perivascular fibroblasts in fibrotic scars.

Their research is published in the journal Nature Communications.

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Pulsatile tinnitus (PT) is a challenging diagnostic condition arising from various vascular, neoplastic, and systemic disorders. Non-invasive imaging is essential for identifying underlying causes while minimizing risks of invasive diagnostic angiography. Although no consensus exists on the primary imaging modality for PT and currently CT, ultrasound, and MRI are used in the diagnostic pathway, MRI is increasingly preferred as the first-line screening test for its diagnostic efficacy and safety. MRI protocols such as time-of-flight, magnetic resonance angiography, diffusion-weighted imaging, and arterial spin labeling can identify serious causes, including vascular shunting lesions, venous sinus stenosis, and tumors.

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Passenger aircraft doors are still primarily manufactured by hand. A particularly time-consuming aspect is assembling the door structures using screws and rivets. Numerous intermediate steps are required to prevent direct contact between different materials—which would otherwise lead to corrosion.

However, replacing aluminum, titanium, and thermosets with primarily thermoplastic carbon fiber composites (CFRP), which can be welded together automatically without separating layers, makes the process much faster. Manufacturing time for the door structure drops from 110 hours to 4. The TAVieDA project by Fraunhofer IWU, Fraunhofer LBF, Trelleborg, and Airbus Helicopters has shown this clearly.

Another key factor in shortening assembly times is the for different aircraft door variants. The project team specifically looked for components across various door models that could be standardized—and found success, for example, with the crossbeam. The researchers designed a fully automated assembly line for the most common models and developed fixtures and clamping elements suitable for resistance and ultrasonic welding technologies.

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The abducens nerve (CN VI) is vulnerable to injury during endoscopic endonasal transcavernous surgery. In this study, the authors aimed to develop the surgical anatomic landmark and explore the relationship between the sympathetic nerves (SNs) around the internal carotid artery (ICA) and CN VI within the cavernous sinus (CS).

METHODS:

The relationship and patterns between the SNs and CN VI were investigated in 15 cadaveric specimens. The intraoperative examples of anatomic landmark were presented.

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UnHerd’s Flo Read meets Mars Society Founder, Robert Zubrin.

Watch it on the UnHerd website: https://unherd.com/watch-listen/how-humans-will-live-on-mars/

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Renowned aerospace engineer and President of the Mars Society — which advocates for human exploration and colonisation of Mars — gives us his case for a manned mission to Mars, and all the challenges that getting to the Red Planet may entail. Is Elon Musk one of them?

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