Lifeboat Foundation: Safeguarding Humanity
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U.S. DARPA’s Robotic Autonomy in Complex Environments with Resiliency (RACER) program recently conducted its third experiment to assess the performance of off-road unmanned vehicles. These test runs, conducted March 12–27, included the first with completely uninhabited RACER Fleet Vehicles (RFVs), with a safety operator overseeing in a supporting chase vehicle. The goal of the RACER program is to demonstrate autonomous movement of combat-scale vehicles in complex, mission-relevant off-road environments that are significantly more unpredictable than on-road conditions. The multiple courses were in the challenging and unforgiving terrain of the Mojave Desert at the U.S. Army’s National Training Center (NTC) in Ft. Irwin, California. As at the previous events, teams from Carnegie Mellon University, NASA’s Jet Propulsion Laboratory, and the University of Washington participated. This completed the project’s first phase.

“We provided the performers RACER fleet vehicles with common performance, sensing, and compute. This enables us to evaluate the performance of the performer team autonomy software in similar environments and compare it to human performance,” said Young. “During this latest experiment, we continued to push vehicle limits in perceiving the environments to greater distances, enabling further increase in speeds and better adaptation to newly encountered environmental conditions that will continue into RACER’s next phase.”

“At Experiment Three, we successfully demonstrated significant improvements in our off-road speeds while simultaneously reducing any interaction with the vehicle during test runs. We were also honored to have representatives from the Army and Marine Corps at the experiment to facilitate transition of technologies developed in RACER to future service unmanned initiatives and concepts,” said Stuart Young, RACER program manager in DARPA’s Tactical Technology Office.

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Vrgineers and Advanced Realtime Tracking demonstrate the combination of XTAL 3 headset and SMARTTRACK3/M in a mixed reality pilot trainer. The partnership between these two technological companies started in 2018. At IT2EC 2023 in Rotterdam, the integrated SMARTTRACK3/M into an F-35-like Classroom Trainer manufactured and delivered to USAF and RAF will be for display. This unique combination of the latest ART infrared all-in-one hardware and Vrgineers algorithms for cockpit motion compensation creates an unseen immersion for every mixed reality training. One of the challenges in next-generation pilot training using virtual technology and motion platforms is the alignment of the pilot’s position in the cockpit. By overcoming this issue, the simulator industry is moving forward to eliminate the disadvantages of simulated training.

“We are continuously working on removing the technological challenges of modern simulators, one of which is caused by front-facing camera position distance from users’ eyes. We are developing advanced algorithms for motion compensation to minimize the shift between virtual and physical scene, making experience realistic. The durability and compact size of SMARTTRACK3/M, which was optimized for using in cockpits, allows us as training device integrator to make it a comprehensive part of a simulation,” says Marek Polcak, CEO of Vrgineers.

“This is the application SMARTTRACK3/M was designed for., We have taken the proven hardware from the SMARTTRACK3 and adapted it to the limited space available. As a result, we have the precision and the reliability of a seasoned system in a form factor fitting to simulator cockpits” says Andreas Werner, business development manager for simulations at ART.

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Despite the availability of imaging-based and mass-spectrometry-based methods for spatial proteomics, a key challenge remains connecting images with single-cell-resolution protein abundance measurements. Deep Visual Proteomics (DVP), a recently introduced method, combines artificial-intelligence-driven image analysis of cellular phenotypes with automated single-cell or single-nucleus laser microdissection and ultra-high-sensitivity mass spectrometry. DVP links protein abundance to complex cellular or subcellular phenotypes while preserving spatial context.

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😗 year 2010 :3.

(PhysOrg.com) — Scientists have literally taken a leap into a new era of computing power by making the world’s smallest precision-built transistor — a “quantum dot” of just seven atoms in a single silicon crystal. Despite its incredibly tiny size — a mere four billionths of a metre long — the quantum dot is a functioning electronic device, the world’s first created deliberately by placing individual atoms.

It can be used to regulate and control electrical current flow like a commercial transistor but it represents a key step into a new age of atomic-scale miniaturisation and super-fast, super-powerful computers.

The discovery is reported today in the journal Nature Nanotechnology by a team from the UNSW Centre for Quantum Computer Technology (CQCT) and the University of Wisconsin-Madison.

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Year 2022 😗

Argonne National Laboratory, Lemont, IL

A team of scientists at the U.S. Department of Energy’s Argonne National Laboratory, have achieved efficient quantum coupling between two distant magnetic devices, which can host a certain type of magnetic excitations called magnons. These excitations happen when an electric current generates a magnetic field. Coupling allows magnons to exchange energy and information. This kind of coupling may be useful for creating new quantum information technology devices.

This instant communication does not require sending a message between magnons limited by the speed of light. It is analogous to what physicists call quantum entanglement. Following on from a 2019 study, the researchers sought to create a system that would allow magnetic excitations to talk to one another at a distance in a superconducting circuit. This would allow the magnons to potentially form the basis of a type of quantum computer. For the basic underpinnings of a viable quantum computer, researchers need the particles to be coupled and stay coupled for a long time.

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Researchers have recently made a groundbreaking discovery in the field of kidney disease. They have found a new pathway that could potentially prevent kidney failure in thousands of people. Dr. Carl May and his team at Bristol Medical School, with funding from Kidney Research UK, have discovered a new treatment pathway for non-genetic nephrotic syndrome.

This targets the unknown factor that leads to kidney failure. Nephrotic syndrome is a rare kidney condition that causes protein to leak into the urine, affecting around 10,000 people annually in the UK. The discovery offers hope for patients, especially children, who may develop kidney failure.

Researchers from Bristol Renal have identified a receptor called PAR-1 that works in conjunction with an unknown factor to cause kidney failure in patients with idiopathic nephrotic syndrome (INS). They found that anti-PAR-1 treatments could block the effect of the factor and prevent kidneys from failing, potentially making transplantation a more viable option for more patients.

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Beyond our own Milky Way galaxy, there are physical limits on our access to the Universe. In this new video from PBS Space Time, we explore the absolute limit of our future view of the Universe, and of the Universe’s ability to influence us.

We humans have always been explorers. The great civilisations that have arisen across the world are owed to our restless ancestors. These days, there’s not much of Earth left to explore. But if we look up, there’s a whole Universe out there waiting for us. Future generations may one day explore the cosmos and could even settle entire other galaxies.

However, there is a fundamental limit to how much of the Universe we can expand into. So, just how big could humanity get? Matt O’Dowd, astrophysicist and host of PBS Space Time, looks at the obstacles that our descendants could face in the very distant future.

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Reversing schizophrenia with gene therapy year 2023.

Copy-number variations in the ARHGAP10 gene encoding Rho GTPase–activating protein 10 are associated with schizophrenia. Model mice (Arhgap10 S490P/NHEJ mice) that carry “double-hit” mutations in the Arhgap10 gene mimic the schizophrenia in a Japanese patient, exhibiting altered spine density, methamphetamine-induced cognitive dysfunction, and activation of RhoA/Rho-kinase signaling. However, it remains unclear whether the activation of RhoA/Rho-kinase signaling due to schizophrenia-associated Arhgap10 mutations causes the phenotypes of these model mice. Here, we investigated the effects of fasudil, a brain permeable Rho-kinase inhibitor, on altered spine density in the medial prefrontal cortex (mPFC) and on methamphetamine-induced cognitive impairment in a touchscreen‑based visual discrimination task in Arhgap10 S490P/NHEJ mice. Fasudil (20 mg/kg, intraperitoneal) suppressed the increased phosphorylation of myosin phosphatase–targeting subunit 1, a substrate of Rho-kinase, in the striatum and mPFC of Arhgap10 S490P/NHEJ mice. In addition, daily oral administration of fasudil (20 mg/kg/day) for 7 days ameliorated the reduced spine density of layer 2/3 pyramidal neurons in the mPFC. Moreover, fasudil (3–20 mg/kg, intraperitoneal) rescued the methamphetamine (0.3 mg/kg)-induced cognitive impairment of visual discrimination in Arhgap10 S490P/NHEJ mice. Our results suggest that Rho-kinase plays significant roles in the neuropathological changes in spine morphology and in the vulnerability of cognition to methamphetamine in mice with schizophrenia-associated Arhgap10 mutations.

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