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Shocking output from Bing’s new chatbot has been lighting up social media and the tech press. Testy, giddy, defensive, scolding, confident, neurotic, charming, pompous—the bot has been screenshotted and transcribed in all these modes. And, at least once, it proclaimed eternal love in a storm of emojis.

What makes all this so newsworthy and tweetworthy is how human the dialog can seem. The bot recalls and discusses prior conversations with other people, just like we do. It gets annoyed at things that would bug anyone, like people demanding to learn secrets or prying into subjects that have been clearly flagged as off-limits. It also sometimes self-identifies as “Sydney” (the project’s internal codename at Microsoft). Sydney can swing from surly to gloomy to effusive in a few swift sentences—but we’ve all known people who are at least as moody.

No AI researcher of substance has suggested that Sydney is within light years of being sentient. But transcripts like this unabridged readout of a two-hour interaction with Kevin Roose of The New York Times, or multiple quotes in this haunting Stratechery piece, show Sydney spouting forth with the fluency, nuance, tone, and apparent emotional presence of a clever, sensitive person.

Engineers at MIT and the University of Massachusetts Medical School have designed a new type of nanoparticle that can be administered to the lungs, where it can deliver messenger RNA encoding useful proteins.

With further development, these could offer an inhalable treatment for and other diseases of the , the researchers say.

“This is the first demonstration of highly efficient delivery of RNA to the lungs in mice. We are hopeful that it can be used to treat or repair a range of genetic diseases, including cystic fibrosis,” says Daniel Anderson, a professor in MIT’s Department of Chemical Engineering and a member of MIT’s Koch Institute for Integrative Cancer Research and Institute for Medical Engineering and Science (IMES).

Turning genes on and off as easily and predictably as flicking a switch could be a powerful tool in medicine and biotech. A type of technology called a riboswitch might be the key. The Okinawa Institute of Science and Technology (OIST) in Japan, in collaboration with Astellas Pharma Inc., has developed a new toolkit that uses small molecules to control the activity of a piece of synthetic RNA, and ultimately regulate gene expression. The technology, which was described in the Journal of the American Chemical Society, worked in mammalian cell cultures and in mice.

The ability to precisely control whether a gene is turned on or off is expected to lead to more efficient production of compounds that are made using animal cells, and make gene therapy, cell therapy, and regenerative medicine safer.

For genes to be expressed, cells make many RNA copies of a section of DNA. These RNA copies, called transcripts, are then used to make the protein. This can lead to the introduction of additional genes (either as DNA or RNA) into cells, which can then be used to make new proteins for a wide variety of applications.

Hackers modified an enterprise communication company’s installation software in an attack that could steal credentials and other information from companies around the world, according to an analysis published Wednesday.

Researchers with cybersecurity firm SentinelOne’s SentinelLabs team traced illicit activity flagged by its detection systems back to the installation software from a company called 3CX, which according to its website provides video conferencing and online communication products to companies such as Toyota, McDonalds, Pepsi and Chevron. In total, the company says it serves some 12 million customers globally.

This sort of large-scale attack that takes advantage of a company’s supply chain — similar to how attackers leveraged a flaw within a SolarWinds product update to install backdoors inside its customers’ networks — can be difficult to defend against and could lead to devastating consequences for victims. It’s also the kind of operation that is typically associated with a nation-state hacking group.

Dune Scene Stars: Kyle MacLachlan, Francesca Annis, Jürgen Prochnow, Silvana Mangano Director: David Lynch Writers: Frank Herbert, David Lynch Producer: Raffaella De Laurentiis Music: TOTO Production: Dino De Laurentiis Company, Estudios Churubusco Azteca S.A. Distributon: Universal Pictures Released: 1984

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