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The drug lorlatinib (Lorbrena) is superior to crizotinib (Xalkori) as an initial treatment for people with advanced non-small cell lung cancer (NSCLC) that has changes in the ALK gene, according to new results from a global clinical trial.

The findings are the latest from the CROWN study. Participants were randomly assigned to receive either lorlatinib or crizotinib as a treatment for advanced lung tumors with ALK gene mutations, a disease called ALK-positive lung cancer.

Several years ago, study investigators reported that participants who received lorlatinib went longer without the disease worsening, known as progression-free survival, than those who received crizotinib.

We’ll break down the key points of the patents and make them as understandable as possible. This new patent is likely how Tesla will implement FSD on non-Tesla vehicles, Optimus, and other devices.

Decision Making

Imagine a neural network as a decision-making machine. But building one also requires making a series of decisions about its structure and data processing methods. Think of it like choosing the right ingredients and cooking techniques for a complex recipe. These choices, called “decision points,” play a crucial role in how well the neural network performs on a given hardware platform.

MIT physicists have taken a key step toward solving the puzzle of what leads electrons to split into fractions of themselves. Their solution sheds light on the conditions that give rise to exotic electronic states in graphene and other two-dimensional systems.

The new work is an effort to make sense of a discovery that was reported earlier this year by a different group of physicists at MIT, led by Assistant Professor Long Ju. Ju’s team found that electrons appear to exhibit “fractional charge” in pentalayer graphene — a configuration of five graphene layers that are stacked atop a similarly structured sheet of boron nitride.

Ju discovered that when he sent an electric current through the pentalayer structure, the electrons seemed to pass through as fractions of their total charge, even in the absence of a magnetic field. Scientists had already shown that electrons can split into fractions under a very strong magnetic field, in what is known as the fractional quantum Hall effect. Ju’s work was the first to find that this effect was possible in graphene without a magnetic field — which until recently was not expected to exhibit such an effect.

Researchers found that methamphetamine and PCP cause a phenomenon known as neurotransmitter switching, impairing memory. This change is reversible, pointing to potential treatments for drug-induced cognitive deficits and related neuropsychiatric conditions.

Researchers have significantly accelerated ion movement using nanotechnology, potentially improving technologies from battery charging to biosensing.

This breakthrough at Washington State University and Lawrence Berkeley National Laboratory involves creating a nanochannel lined with molecules that attract ions, allowing them to move over ten times faster than before. This development could revolutionize energy storage and help detect environmental pollutants or neurological activities.

Breaking Speed Records With Nanoscience