Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog – Page 3691

The pursuit of a cure for Alzheimer’s disease is becoming an increasingly competitive and contentious quest with recent years witnessing several important controversies.

In July 2022, Science magazine reported that a key 2006 research paper, published in the prestigious journal Nature, which identified a subtype of brain protein called beta-amyloid as the cause of Alzheimer’s, may have been based on fabricated data.

One year earlier, in June 2021, the US Food and Drug Administration had approved aducanumab, an antibody-targeting beta-amyloid, as a treatment for Alzheimer’s, even though the data supporting its use were incomplete and contradictory.

Read more | >

A research team led by the German Cancer Research Center in Heidelberg, Germany, has discovered that the genetic sequence of a tumor can be read like a molecular clock, traced back to its most recent common ancestor cell. Extracting the duration of tumor evolution can give an accurate predictor of neuroblastoma outcomes.

In a paper published in Nature Genetics titled “Neuroblastoma arises in early fetal development and its evolutionary duration predicts outcome,” the team details the steps they took in identifying a genomic clock tested against a sequenced population combined with analysis and mathematical modeling, to identify evolution markers, traceability and a likely origin point of infant neuroblastomas.

Cancer cells start out life as heroic healthy tissues, with the sort of all for one, one for all, throw yourself on a grenade to save your mates–type attitude that is taking place throughout the body every day. At some point, something goes wrong, and a good cell goes bad.

Read more | >

The use of time-lapse monitoring in IVF does not result in more pregnancies or shorten the time it takes to get pregnant. This new method, which promises to “identify the most viable embryos,” is more expensive than the classic approach. Research from Amsterdam UMC, published today in The Lancet, shows that time-lapse monitoring does not improve clinical results.

Patients undergoing an IVF treatment often have several usable embryos. The laboratory then makes a choice as to which embryo will be transferred into the uterus. Crucial to this decision is the cell division pattern in the first three to five days of embryo development. In order to observe this, embryos must be removed from the incubator daily to be checked under a microscope. In time-lapse incubators, however, built-in cameras record the development of each embryo. This way embryos no longer need to be removed from the stable environment of the incubator and a computer algorithm calculates which embryo has shown the most optimal growth pattern.

More and more IVF centers, across the world, use time-lapse for the evaluation and selection of embryos. Prospective parents are often promised that time-lapse monitoring will increase their chance of becoming pregnant. Despite frequent use of this relatively expensive method, there are hardly any large clinical studies evaluating the added value of time-lapse monitoring for IVF treatments.

Read more | >

Using a self-built inverted microscope complete with laser optical tweezers to capture DNA, Yale Cancer Center and University of California Davis researchers for the first time created a visualization of the full-length human BRCA2 protein at the single molecule level.

Mutations in the breast cancer susceptibility gene, BRCA2, can significantly increase an individual’s lifetime risk of developing cancer. Approximately one in every 400 people carry a BRCA gene mutation accounting for a significant proportion of cancer that is heritable. The study was published on March 28 in the Proceedings of the National Academy of Sciences.

“If you carry a BRCA mutation, you have this incredibly high risk for breast and , and also for men, prostate and ,” said Yale Cancer Center member and co-author of the paper, Ryan Jensen, Ph.D., who is also an associate professor of therapeutic Radiology at Yale School of Medicine.

Read more | >

A surge of trojanized Tor Browser installers targets Russians and Eastern Europeans with clipboard-hijacking malware that steals infected users’ cryptocurrency transactions.

Kaspersky analysts warn that while this attack is not new or particularly creative, it’s still effective and prevalent, infecting many users worldwide.

While these malicious Tor installers target countries worldwide, Kaspersky says that most are targeting Russia and Eastern Europe.

Read more | >

It can take off vertically with a lead-up (defined as the length of runway needed for take-off) of less than 300 feet, hover in austere environments, and fly forward at more than 450 miles per hour. And, by the way, it’s probably a fixed-wing plane.

That, at least, is the idea behind DARPA’s SPRINT X-plane, a project in the beginning stages of development for use by the U.S. Special Operations Command (SOCOM). The Defense Advanced Research Projects Agency recently called for proposals for a plane with a mind-bending set of capabilities. According to the March solicitation, DARPA wants a scaled demonstrator ready to fly within the next three-and-a-half years.

SPRINT, naturally, stands for “SPeed and Runway INdependent Technologies.”

Read more | >