Lifeboat Foundation: Safeguarding Humanity
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Beyond our own Milky Way galaxy, there are physical limits on our access to the Universe. In this new video from PBS Space Time, we explore the absolute limit of our future view of the Universe, and of the Universe’s ability to influence us.

We humans have always been explorers. The great civilisations that have arisen across the world are owed to our restless ancestors. These days, there’s not much of Earth left to explore. But if we look up, there’s a whole Universe out there waiting for us. Future generations may one day explore the cosmos and could even settle entire other galaxies.

However, there is a fundamental limit to how much of the Universe we can expand into. So, just how big could humanity get? Matt O’Dowd, astrophysicist and host of PBS Space Time, looks at the obstacles that our descendants could face in the very distant future.

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Reversing schizophrenia with gene therapy year 2023.

Copy-number variations in the ARHGAP10 gene encoding Rho GTPase–activating protein 10 are associated with schizophrenia. Model mice (Arhgap10 S490P/NHEJ mice) that carry “double-hit” mutations in the Arhgap10 gene mimic the schizophrenia in a Japanese patient, exhibiting altered spine density, methamphetamine-induced cognitive dysfunction, and activation of RhoA/Rho-kinase signaling. However, it remains unclear whether the activation of RhoA/Rho-kinase signaling due to schizophrenia-associated Arhgap10 mutations causes the phenotypes of these model mice. Here, we investigated the effects of fasudil, a brain permeable Rho-kinase inhibitor, on altered spine density in the medial prefrontal cortex (mPFC) and on methamphetamine-induced cognitive impairment in a touchscreen‑based visual discrimination task in Arhgap10 S490P/NHEJ mice. Fasudil (20 mg/kg, intraperitoneal) suppressed the increased phosphorylation of myosin phosphatase–targeting subunit 1, a substrate of Rho-kinase, in the striatum and mPFC of Arhgap10 S490P/NHEJ mice. In addition, daily oral administration of fasudil (20 mg/kg/day) for 7 days ameliorated the reduced spine density of layer 2/3 pyramidal neurons in the mPFC. Moreover, fasudil (3–20 mg/kg, intraperitoneal) rescued the methamphetamine (0.3 mg/kg)-induced cognitive impairment of visual discrimination in Arhgap10 S490P/NHEJ mice. Our results suggest that Rho-kinase plays significant roles in the neuropathological changes in spine morphology and in the vulnerability of cognition to methamphetamine in mice with schizophrenia-associated Arhgap10 mutations.

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face_with_colon_three year 2022.

For the first time, scientists have created a quantum computing experiment for studying the dynamics of wormholes – that is, shortcuts through spacetime that could get around relativity’s cosmic speed limits.

Wormholes are traditionally the stuff of science fiction, ranging from Jodie Foster’s wild ride in Contact to the time-bending plot twists in Interstellar. But the researchers behind the experiment, reported in the December 1 issue of the journal Nature, hope that their work will help physicists study the phenomenon for real.

“We found a quantum system that exhibits key properties of a gravitational wormhole, yet is sufficiently small to implement on today’s quantum hardware,” Caltech physicist Maria Spiropulu said in a news release. Spiropulu, the Nature paper’s senior author, is the principal investigator for a federally funded research program known as Quantum Communication Channels for Fundamental Physics.

Continue reading “A ‘Wormhole’ Built on a Quantum Computer Teleported Information as Predicted” | >

Chat gpt 4 is wonderful but one thing it is lacking is sentience which could do all work for millions of years so essentially we would not need find all discoveries and all things by ourselves.

Richards said he originally wanted an AI agent to automatically email him daily AI news. But, as Motherboard, he realized in the process that existing LLMs struggle with “tasks that require long-term planning,” or are “unable to autonomously refine their approaches based on real-time feedback.” That understanding inspired him to create Auto-GPT, which, he said, “can apply GPT4’s reasoning to broader, more complex problems that require long-term planning and multiple steps.” (Richards didn’t respond for a request for an interview with Fast Company.)

“They get confused”

Autonomous agents, at this early stage, are mainly experimental. And they have some serious limitations that prevent them from getting what they want from large language models…

Continue reading “Auto-GPT and BabyAGI: How ‘autonomous agents’ are bringing generative AI to the masses” | >

DJI has just unveiled its most advanced camera drone to date, but its hefty $16,500 price tag suggests it’s not for the everyday user.

Indeed, the new Inspire 3 is designed for professional moviemakers who want a powerful machine capable of nailing the best shots.

An update of the Inspire 2 that launched in 2016, the Inspire 3 sports a new streamlined design that offers improved mobility for complex maneuvers.

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NAIROBI, April 14 (Reuters) — Kenya launched its first operational earth observation satellite on Saturday onboard a SpaceX rocket from the United States, a live feed from Elon Musk’s rocket company showed.

The satellite, developed by nine Kenyan engineers, will collect agricultural and environmental data, including on floods, drought and wildfires, that authorities plan to use for disaster management and to combat food insecurity.

The Falcon 9 rocket carrying the Taifa-1 satellite, took off at about 648 GMT without incident from Vandenberg Base in California, after three postponements due to bad weather.

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Proteins are involved in every biological process, and use the energy in the body to alter their structure via mechanical movements. They are considered biological ‘nanomachines’ because the smallest structural change in a protein has a significant effect on biological processes. The development of nanomachines that mimic proteins has received much attention to implement movement in the cellular environment. However, there are various mechanisms by which cells attempt to protect themselves from the action of these nanomachines. This limits the realization of any relevant mechanical movement of nanomachines that could be applied for medical purposes.

The research team led by Dr. Youngdo Jeong from the Center for Advanced Biomolecular Recognition at the Korea Institute of Science and Technology (KIST, President Seok-Jin Yoon) has reported the development of a novel biochemical nanomachine that penetrates the cell membrane and kills the cell via the molecular movements of folding and unfolding in specific cellular environments, such as cancer cells, as a result of a collaboration with the teams of Prof. Sang Kyu Kwak from the School of Energy and Chemical Engineering and Prof. Ja-Hyoung Ryu from the Department of Chemistry at the Ulsan National Institute of Science and Technology (UNIST, President Yong Hoon Lee), and Dr. Chaekyu Kim of Fusion Biotechnology, Inc.

The joint research team focused on the hierarchical structure of proteins, in which the axis of the large structure and the mobile units are hierarchically separated. Therefore, only specific parts can move around the axis. Most existing nanomachines have been designed so that the mobile components and axis of the large structure are present on the same layer. Thus, these components undergo simultaneous movement, which complicates the desired control of a specific part.

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Year 2022 face_with_colon_three

This work rests on our non-viral tissue nanotransfection (TNT) platform to deliver MyoD (TNTMyoD) to injured tissue in vivo. TNTMyoD was performed on skin and successfully induced expression of myogenic factors. TNTMyoD was then used as a therapy 7 days following volumetric muscle loss (VML) of rat tibialis anterior and rescued muscle function. TNTMyoD is promising as VML intervention.

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