Lifeboat Foundation

The findings, published in the Journal of Neuroscience, may help explain how humans form memories and learn, and could eventually aid the development of assistive tools for people affected by neurologic disease or injury. The study was conducted by Massachusetts General Hospital in collaboration with colleagues at Brown University, the Department of Veterans Affairs, and several other institutions.

By MGH news and public affairs.

A widely believed theory about the origins of Native Americans has been dealt a huge blow by a new genetic analysis of ancient teeth, implying the ancient inhabitants of what is now America were not who we thought they were.

The theory, largely based on archaeological evidence found at Native American sites, claims that the First Peoples came to the continent from Japan around 15,000 years ago. Stone tools and other stone artifacts used by Native Americans show similarities to those of the Jōmon people, a diverse hunter-gatherer people who lived in ancient Japan from around 14,000–300 BCE.

Based on this and analysis of their migration across the continent, it’s been suggested that Native Americans made their way across the northern rim of the Pacific Ocean, across the Bering Land Bridge – dry land that connected Siberia and Alaska during the last ice age – until they reached the northwest coast of North America.

Reposting 😗

Thanks to a new experimental gene therapy, one teen’s previously incurable leukemia is now entirely undetectable, marking an incredible breakthrough in genetic immunotherapies. Alyssa, 13, from Leicester in the UK, was told that the only remaining options were end-of-life care to ensure she was comfortable as the aggressive T-cell acute lymphoblastic leukemia took hold – but the experimental CAR-T base editing therapy was able to modify her immune system to clear all detectable cancer cells.

T-cell lymphoblastic leukemia is a type of cancer that affects T-lymphocytes, an immune white blood cell that is created in the bone marrow. In this type of fast-moving leukemia, these cells divide uncontrollably and enter the bloodstream, traveling to the liver, spleen, and lymph nodes. This can cause death in a short span of just months or even weeks without treatment.

Continue reading “Experimental Gene Therapy Cures Teen’s ‘Incurable’ Cancer” »

‘Most complicated therapy ever’ tailors bespoke, genome-edited immune cells to attack tumours.

A true embodiment of French Gothic expression in architecture, Chartres Cathedral sits some 50 miles southwest of Paris, in the commune of Chartres. The cathedral was built to be higher and bigger than other cathedrals of the era.

One of the cathedral’s most famous features is its intricate labyrinth located in the nave. Little is known about the cathedral builders, therefore little is known about the motives behind one of the most enigmatic labyrinth depictions in the world.

Construction of the Chartres Cathedral unfolded rather faster than was the case with other cathedrals at the time. For instance, the Notre Dame in Paris took almost two centuries to accomplish, starting from 1160. On the Chartres site, activities reportedly began in 1,194 and finished in 1221.

Most of us underestimate how quickly electric vehicles (EVs) will take over the car market. It’s mostly down to the plummeting cost of batteries. They have only become cost-competitive in the last few years and have fallen in price 98% since the 1990s. (99% if you include inflation.)

This gave me a combined series of the unit cost of lithium-ion batteries from 1991 to 2022 in $2022. I’ve plotted it as a chart here. And here is the logarithmic version.

Calculating the cost of EV batteries

Continue reading “Electric vehicle batteries would have cost as much as a million dollars in the 1990s” »

The body constantly replaces used materials and breaks them down for disposal. MPS VI patients are missing an enzyme essential to breaking down the mucopolysaccharide dermatan sulfate. These materials remain stored in the body’s cells, causing progressive damage. Babies may show little sign of the disease (so better testing is needed), but as cells sustain damage, symptoms start to appear.

Its sad when people have disorders that have a low life expectancy in their 20’s and 30’s EnzymeMaroteaux-Lamy syndrome Is one such affliction, however their is enzyme replacement treatment, but more needs to be done.

Enzyme Replacement Treatment.

Continue reading “MPS VI” »

Google has released OSV-Scanner, an open-source front-end interface to the Open Source Vulnerability (OSV) database. The OSV database is a distributed, open-source database that stores vulnerability information in the OSV format. The OSV-Scanner assesses a project’s dependencies against the OSV database showing all vulnerabilities relating to the project.

A team of researchers has discovered at least two new minerals that have never before been seen on Earth in a 15 tonne meteorite found in Somalia — the ninth largest meteorite ever found.

“Whenever you find a new mineral, it means that the actual geological conditions, the chemistry of the rock, was different than what’s been found before,” says Chris Herd, a professor in the Department of Earth & Atmospheric Sciences and curator of the University of Alberta’s Meteorite Collection. “That’s what makes this exciting: In this particular meteorite you have two officially described minerals that are new to science.”

The two minerals found came from a single 70 gram slice that was sent to the U of A for classification, and there already appears to be a potential third mineral under consideration. If researchers were to obtain more samples from the massive meteorite, there’s a chance that even more might be found, Herd notes.