Did Mars once have life as we know it deep in its ancient past? A recent study published in Proceedings of the National Academy of Sciences might be one st | Space
Pharmacologic Treatments of Acute Episodic Migraine Headache in Outpatient Settings: A Clinical Guideline From the American College of PhysiciansFREE
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Description: The American College of Physicians (ACP) developed this guideline based on the best available evidence on the comparative benefits and harms of pharmacologic treatments of acute episodic migraine headache, patients’ values and preferences, and economic evidence about these pharmacologic treatments. Methods: This guideline is based on a systematic review and network meta-analysis of the comparative benefits and harms of pharmacologic treatments of acute episodic migraine headaches, as well as systematic reviews of patients’ values and preferences and comparative cost-effectiveness analyses. The Clinical Guidelines Committee evaluated the following clinical outcomes using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach: pain freedom and pain relief at 2 hours; sustained pain freedom and sustained pain relief up to 48 hours; need for rescue medication within 24 hours; nausea, vomiting, and restored physical function at 2 hours; and overall and serious adverse events (AEs). Additional data on AEs were captured through U.S. Food and Drug Administration medication labels. Audience and Population: The audience for this clinical guideline is physicians and other clinicians. The population is adults with acute episodic migraine headache (defined as 1 to 14 headache days per month) managed in outpatient settings. Recommendation 1: ACP recommends that clinicians add a triptan to a nonsteroidal anti-inflammatory drug to treat moderate to severe acute episodic migraine headache in outpatient settings for nonpregnant adults who do not respond adequately to a nonsteroidal anti-inflammatory drug (strong recommendation; moderate-certainty evidence). Recommendation 2: ACP suggests that clinicians add a triptan to acetaminophen to treat moderate to severe acute episodic migraine headache in outpatient settings for nonpregnant adults who do not respond adequately to acetaminophen (conditional recommendation; low-certainty evidence).
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A DNA nanomachine selectively targets skin cancer by detecting microRNA-7, activating phototherapy and releasing chemotherapy drugs while generating oxygen to enhance treatment.
The Sydney start-up is part of Australia’s burgeoning domestic defence industry, which increasingly features not just local subsidiaries of big multinationals, but also a growing number of homegrown firms.
The standard model of particle physics is our best theory of the elementary particles and forces that make up our world: particles and antiparticles, such as electrons and positrons, are described as quantum fields. They interact through other force fields, such as the electromagnetic force that binds charged particles.
To understand the behavior of these quantum fields—and with that, our universe—researchers perform complex computer simulations of quantum field theories. Unfortunately, many of these calculations are too complicated for even our best supercomputers and pose great challenges for quantum computers as well, leaving many pressing questions unanswered.
Using a novel type of quantum computer, Martin Ringbauer’s experimental team at the University of Innsbruck, and the theory group led by Christine Muschik at IQC at the University of Waterloo, Canada, report in Nature Physics on how they have successfully simulated a complete quantum field theory in more than one spatial dimension.
We’re on a journey to advance and democratize artificial intelligence through open source and open science.
The DeepSeek-V3-0324, named after its predecessor and the launch date, has “enhanced reasoning capabilities, optimised front-end web development and upgraded Chinese writing proficiency”, according to a notice on the company’s website.
The new version and DeepSeek V3 are both foundation models trained on vast data sets that can be applied in different use cases, including that of a chatbot. DeepSeek R1, the reasoning model, is based on DeepSeek V3.
The updated foundation model has made improvements in several benchmarks, especially the American Invitational Mathematics Examination (AIME), where it scored 59.4 compared with 39.6 for its predecessor, while achieving an increase of 10 points on LiveCodeBench to achieve 49.2, DeepSeek data showed.
Korean researchers have developed a digital holography processor that converts two-dimensional (2D) videos into real-time three-dimensional (3D) holograms. This technology is expected to play a key role in the future of holography, as it enables the instantaneous transformation of ordinary 2D videos into 3D holograms.
The Electronics and Telecommunications Research Institute (ETRI) has announced the development of a programmable semiconductor-based digital holographic media processor (RHP) using Field Programmable Gate Array (FPGA) technology. This processor can convert 2D video into 3D holograms in real-time.
The real-time holography processor is the world’s first to utilize high-bandwidth memory (HBM) to generate real-time, full-color 3D holograms from 2D video. Notably, all the hardware required for hologram generation is integrated into a single system-on-chip (SoC).
In 1971, American electrical engineer and computer scientist Leon Chua reasoned that there must exist a fourth fundamental element of computing. There’s the resistor, capacitor, and inductor, but Chua believed there also existed a “memristor”— a portmanteau of “memory” and “resistor” that described a simple, non-volatile memory component that could store information even when turned off.
This sounds like a simple function, but it provides the technological foundation of neuromorphic (a.k.a. brain-like) computing—an effective memristor would essentially act as an artificial synapse in an AI neural net, as it can achieve both data storage and computation at the same time (which is something our brain does). Since researchers “discovered” memristors back in 2008, scientists and engineers around the world have been slowly improving their capabilities in the hopes of bringing about computers that are as efficient and powerful as human brains.